scholarly journals Synthesis and Bioevaluation of Novel Imatinib Base Derivatives via 1,1′-Carbonyldiimidazole Catalyst

2013 ◽  
Vol 2013 ◽  
pp. 1-7
Author(s):  
M. J. Patoliya ◽  
G. J. Kharadi
Keyword(s):  
Antimicrobial Activity ◽  
Carboxylic Acid ◽  
Elemental Analysis ◽  
Solvent Free ◽  
The Other ◽  
Solvent Free Conditions ◽  
Imatinib Base

A series of eleven compounds were synthesized from 6-methyl-N′-(4-(pyridine-3-yl)pyrimidin-2-yl)benzene-1,3-diamine with various substituted carboxylic acid under solvent-free conditions using 1,1′-carbonyldiimidazole (CDI) as a catalyst. The yields of compounds are more than 72%. All the compounds were characterized by physical, spectroscopic, and elemental analysis. Compound8bexhibited good inhibition towards antimicrobial activity compared to the other compounds.

Chlorosulfonic Acid Supported Piperidine-4-carboxylic Acid (PPCA) Functionalized Fe3O4 Nanoparticles (Fe3O4-PPCA): The Efficient, Green and Reusable Nanocatalyst for the Synthesis of Pyrazolyl Coumarin Derivatives under Solvent-Free Conditions

2019 ◽  
Vol 22 (2) ◽  
pp. 123-128
Author(s):  
Setareh Habibzadeh ◽  
Hassan Ghasemnejad-Bosra ◽  
Mina Haghdadi ◽  
Soheila Heydari-Parastar
Keyword(s):  
Carboxylic Acid ◽  
Fe3o4 Nanoparticles ◽  
High Efficiency ◽  
Reaction Times ◽  
Chlorosulfonic Acid ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Magnetic Nanocatalyst ◽  
One Pot ◽  
Solvent Free Conditions

Background: In this study, we developed a convenient methodology for the synthesis of coumarin linked to pyrazolines and pyrano [2,3-h] coumarins linked to 3-(1,5-diphenyl-4,5- dihydro-1H-pyrazol-3-yl)-chromen-2-one derivatives using Chlorosulfonic acid supported Piperidine-4-carboxylic acid (PPCA) functionalized Fe3O4 nanoparticles (Fe3O4-PPCA) catalyst. Materials and Methods:: Fe3O4-PPCA was investigated as an efficient and magnetically recoverable Nanocatalyst for the one-pot synthesis of substituted coumarins from the reaction of coumarin with a variety of aromatic aldehydes in high to excellent yield at room temperature under solvent-free conditions. The magnetic nanocatalyst can be easily recovered by applying an external magnet device and reused for at least 10 reaction runs without considerable loss of reactivity. Results and Conclusion: The advantages of this protocol are the use of commercially available materials, simple and an inexpensive procedure, easy separation, and an eco-friendly procedure, and it shows good reaction times, good to high yields, inexpensive and practicability procedure, and high efficiency.

scholarly journals Poly(ethylene glycol) Supported Metal Nitrates as Well-Organized Reagents for Hunsdiecker Conversion of α,β-Unsaturated Acids to β-Nitrostyrenes under Solvent and Acid-Free Conditions

2019 ◽  
Vol 31 (8) ◽  
pp. 1798-1800
Author(s):  
K. Ramesh ◽  
S. Shylaja ◽  
S. Ramgopal ◽  
A. Sambashiva Rao ◽  
K.C. Rajanna
Keyword(s):  
Ethylene Glycol ◽  
Solvent Free ◽  
The Other ◽  
Ferric Nitrate ◽  
Poly Ethylene Glycol ◽  
Peg 400 ◽  
Metal Nitrates ◽  
Solvent Free Conditions ◽  
Poly Ethylene ◽  
Supported Metal

Poly(ethylene glycol) (PEG) supported metal nitrates such as ferric nitrate and manganese nitrate were accomplished as well-organized reagents for Hunsdiecker conversion of α,β-unsaturated acids to β-nitrostyrenes under acid-free and solvent free conditions using grind-stone technique. However, in the case of unsaturated aliphatic acids, nitro alkene derivatives were obtained as products. PEG-400 was found the best among the other PEGs (PEG-200,300, 400, 600, 3000 and 6000) used in this protocol.

Substitution of Cyano Group in Position 5 of 1,2,4-Triazines by Carboxylic Acid Hydrazide Residues under Solvent-Free Conditions

2018 ◽  
Vol 54 (3) ◽  
pp. 509-511 ◽  
Author(s):  
D. S. Kopchuk ◽  
A. P. Krinochkin ◽  
E. S. Starnovskaya ◽  
Ya. K. Shtaitz ◽  
I. S. Kovalev ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Cyano Group ◽  
Acid Hydrazide ◽  
Solvent Free ◽  
Carboxylic Acid Hydrazide ◽  
Solvent Free Conditions

scholarly journals A Facial Synthesis and Antimicrobial Activity of Some Pyrazole Derivatives Carrying Indole

2010 ◽  
Vol 7 (3) ◽  
pp. 745-750 ◽  
Author(s):  
K. Narasimha Sarma ◽  
M. C. S. Subha ◽  
K. Chowdoji Rao
Keyword(s):  
Antimicrobial Activity ◽  
Acetic Acid ◽  
Carboxylic Acid ◽  
Hydrazine Hydrate ◽  
Elemental Analysis ◽  
Antimicrobial Activities ◽  
Subsequent Treatment ◽  
Spectral Studies ◽  
Pyrazole Derivatives

The title compounds (7a-h) were prepared by esterification of indole-5-carboxylic acid (1) and subsequent treatment with hydrazine hydrate in methanolviathe hydrazide (3). Finally hydrazide (3) condensed with different substituted aldol (6) in acetic acid / PTSA catalytic media produced (3,5-subsituted-4,5-dihydropyrazol-1-yl)(1H-indol-5-yl)methanone (7a-h) in good yields. All the newly synthesized compounds are by elemental analysis and spectral studies and evaluated for antimicrobial activities.

scholarly journals Synthesis and Antimicrobial Activity of 7-Hydroxy-3',4'-Methylenedioxy- and 7-Benzyloxy-3',4'-Methylenedioxy Flavanones

2017 ◽  
Vol 9 (3) ◽  
pp. 297-306 ◽  
Author(s):  
R. Ali ◽  
A. Rahim ◽  
A. Islam
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Elemental Analysis ◽  
The Other ◽  
Antifungal Activities ◽  
Fungal Strains ◽  
Antibacterial And Antifungal Activities ◽  
Other Hand ◽  
Antibacterial And Antifungal

7-Hydroxy-3',4'-methylenedioxy- and 7-benzyloxy-3',4'-methylenedioxy flavanones have been synthesized starting from 2,4-dihydroxyacetophenone. Subsequently biocidal activities of the flavanones have been investigated along with their corresponding chalcones against some bacterial and fungal strains. 2'-Hydroxy-4'-benzyloxy-3,4-methylenedioxy chalcone (5) and its corresponding flavanone (7) showed good antibacterial and antifungal activities against some selected bacterial and fungal strains. On the other hand, 2',4'-dihydroxy-3,4-methylenedioxy chalcone (4) showed no antibacterial and antifungal activities while its corresponding flavanone (6) showed a little antibacterial activity only at higher concentration but did not show antifungal activity. The synthesized chalcones and flavanones have been characterized using UV-Vis, IR and 1H NMRspectral data together with elemental analysis.

scholarly journals Urea nitrate catalyzed synthesis of 2-arylbenzothiazoles using the grindstone technique

2018 ◽  
Vol 24 (6) ◽  
pp. 307-310 ◽  
Author(s):  
Divyani Gandhi ◽  
Shikha Agarwal
Keyword(s):  
Elemental Analysis ◽  
Spectral Methods ◽  
Environmentally Friendly ◽  
Solvent Free ◽  
Urea Nitrate ◽  
Solvent Free Conditions

Abstract An efficient, green and environmentally friendly grindstone method for the synthesis of 2-arylbenzothiazole derivatives in the presence of urea nitrate as the catalyst under solvent-free conditions was developed. All products were characterized by elemental analysis and spectral methods.

Zinc Mediated Selective Acylation of Ferrocene under Solvent-Free Conditions

2007 ◽  
Vol 2007 (7) ◽  
pp. 426-428 ◽  
Author(s):  
Vishal H. Purecha ◽  
Nitin S. Nandurkar ◽  
Bhalchandra M. Bhanage ◽  
Jayashree M. Nagarkar
Keyword(s):  
Reaction Time ◽  
Carboxylic Acid ◽  
Environmentally Friendly ◽  
Operating Conditions ◽  
Solvent Free ◽  
Acyl Chloride ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
Selective Acylation ◽  
Environmentally Friendly Method

A simple, convenient and environmentally-friendly method for selective acylation of ferrocene to monoacylferrocene in the presence of Zn metal under solvent-free conditions is described. The protocol requires mild operating conditions, affording higher yields of desired products both with acyl chloride/carboxylic acid within a short reaction time (15–30 min).

Sign in / Sign up

Export Citation Format

Share Document