cocrystal screening
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Author(s):  
Chiara Cappuccino ◽  
David Cusack ◽  
James Flanagan ◽  
Carl Harrison ◽  
Cillian Holohan ◽  
...  

CrystEngComm ◽  
2022 ◽  
Author(s):  
Jay Makadia ◽  
Shadrack J Madu ◽  
Randolph Arroo ◽  
Colin Cormack Seaton ◽  
Mingzhong Li

Artemisinin is used to treat malaria, even when caused by multi-drug resistant strains of the Plasmodium parasite; the compound also shows good promise as an anti-cancer drug. However, the usage...


Author(s):  
Di Wu ◽  
Bei Zhang ◽  
Qichao Yao ◽  
Baohong Hou ◽  
Lina Zhou ◽  
...  

2021 ◽  
Vol 45 (6) ◽  
pp. 3034-3047
Author(s):  
Artem O. Surov ◽  
Alexander P. Voronin ◽  
Nikita A. Vasilev ◽  
Andrey B. Ilyukhin ◽  
German L. Perlovich

Five new multicomponent solid forms of the biologically active 1,2,4-thiadiazole derivative (TDZH) with dicarboxylic and hydroxybenzoic acids have been discovered by combined virtual/experimental cocrystal screening.


Pharmaceutics ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1209
Author(s):  
Si Nga Wong ◽  
Susan Wing Sze Chan ◽  
Xuexin Peng ◽  
Bianfei Xuan ◽  
Hok Wai Lee ◽  
...  

The kinetic entrapment of molecules in an amorphous phase is a common obstacle to cocrystal screening using rapid solvent removal, especially for drugs with a moderate or high glass-forming ability (GFA). The aim of this study was to elucidate the effects of the coformer’s GFA and annealing conditions on the nature of amorphous phase transformation to the cocrystal counterpart. Attempts were made to cocrystallize voriconazole (VRC) with four structural analogues, namely fumaric acid (FUM), tartaric acid (TAR), malic acid (MAL), and maleic acid (MAE). The overall GFA of VRC binary systems increased with decreasing glass transition temperatures (Tgs) of these diacids, which appeared as a critical parameter for predicting the cocrystallization propensity such that a high-Tg coformer is more desirable. A new 1:1 VRC-TAR cocrystal was successfully produced via a supercooled-mediated re-cocrystallization process, and characterized by PXRD, DSC, and FTIR. The cocrystal purity against the annealing temperature displayed a bell-shaped curve, with a threshold at 40 °C. The isothermal phase purity improved with annealing and adhered to the Kolmogorov–Johnson–Mehl–Avrami kinetics. The superior dissolution behavior of the VRC-TAR cocrystal could minimize VRC precipitation upon gastric emptying. This study offers a simple but useful guide for efficient cocrystal screening based on the Tg of structurally similar coformers, annealing temperature, and time.


2020 ◽  
Vol 20 (11) ◽  
pp. 7320-7327
Author(s):  
Nandini Sarkar ◽  
Nina C. Gonnella ◽  
Mariusz Krawiec ◽  
Dongyue Xin ◽  
Christer B. Aakeröy

CrystEngComm ◽  
2020 ◽  
Vol 22 (25) ◽  
pp. 4210-4214
Author(s):  
Rafael Barbas ◽  
Lídia Bofill ◽  
Dafne de Sande ◽  
Mercè Font-Bardia ◽  
Rafel Prohens

A cocrystal screening of solid solutions of three phytosterols (β-sitosterol, campesterol, stigmasterol) reveals that cocrystal solid solutions are enriched with β-sitosterol with respect to stigmasterol, a natural product with cytotoxicity concerns.


Author(s):  
Ann Newman ◽  
Cen Chen ◽  
Carlos Sanrame
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