scholarly journals Crystal engineering of nutraceutical phytosterols: new cocrystal solid solutions

CrystEngComm ◽  
2020 ◽  
Vol 22 (25) ◽  
pp. 4210-4214
Author(s):  
Rafael Barbas ◽  
Lídia Bofill ◽  
Dafne de Sande ◽  
Mercè Font-Bardia ◽  
Rafel Prohens
Keyword(s):  
Natural Product ◽  
Solid Solutions ◽  
Crystal Engineering ◽  
Cocrystal Screening

A cocrystal screening of solid solutions of three phytosterols (β-sitosterol, campesterol, stigmasterol) reveals that cocrystal solid solutions are enriched with β-sitosterol with respect to stigmasterol, a natural product with cytotoxicity concerns.

scholarly journals Molecular tectonics: crystal engineering of mixed valence Fe(ii)/Fe(iii) solid solutions

2010 ◽  
Vol 46 (6) ◽  
pp. 868-870 ◽  
Author(s):  
Pierre Dechambenoit ◽  
Sylvie Ferlay ◽  
Nathalie Kyritsakas ◽  
Mir Wais Hosseini
Keyword(s):  
Solid Solutions ◽  
Crystal Engineering ◽  
Mixed Valence ◽  
Molecular Tectonics

How Many Cocrystals Are We Missing? Assessing Two Crystal Engineering Approaches to Pharmaceutical Cocrystal Screening

2022 ◽  
Author(s):  
Chiara Cappuccino ◽  
David Cusack ◽  
James Flanagan ◽  
Carl Harrison ◽  
Cillian Holohan ◽  
...  
Keyword(s):  
Crystal Engineering ◽  
Pharmaceutical Cocrystal ◽  
Cocrystal Screening

Template mediated crystal engineering

1994 ◽  
Vol 52 ◽  
pp. 480-481
Author(s):  
Brigid R. Heywood ◽  
S. Champ
Keyword(s):  
Crystal Engineering ◽  
Electrostatic Interactions ◽  
Alkyl Chain ◽  
Crystallographic Axis ◽  
Two Dimensional ◽  
Engineering Process ◽  
Solution Interface ◽  
Extensive Program ◽  
Geometric Homology ◽  
Long Alkyl Chain

Recent work on the crystallisation of inorganic crystals under compressed monomolecular surfactant films has shown that two dimensional templates can be used to promote the oriented nucleation of solids. When a suitable long alkyl chain surfactant is cast on the crystallisation media a monodispersied population of crystals forms exclusively at the monolayer/solution interface. Each crystal is aligned with a specific crystallographic axis perpendicular to the plane of the monolayer suggesting that nucleation is facilitated by recognition events between the nascent inorganic solid and the organic template.For example, monolayers of the long alkyl chain surfactant, stearic acid will promote the oriented nucleation of the calcium carbonate polymorph, calcite, on the (100) face, whereas compressed monolayers of n-eicosyl sulphate will induce calcite nucleation on the (001) face, (Figure 1 & 2). An extensive program of research has confirmed the general principle that molecular recognition events at the interface (including electrostatic interactions, geometric homology, stereochemical complementarity) can be used to promote the crystal engineering process.

Synthetic studies toward inducamide C

2021 ◽  
Author(s):  
Ardalan A. Nabi ◽  
Lydia M. Scott ◽  
Daniel P. Furkert ◽  
Jonathan Sperry
Keyword(s):  
Natural Product ◽  
Structural Revision ◽  
Synthetic Studies

The rare benzoxazepine ring in the alkaloid inducamide C is unstable and prone to rearrangement, indicating that structural revision of the natural product may be necessary.

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