boropinic acid
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2018 ◽  
Vol 124 ◽  
pp. 209-212 ◽  
Author(s):  
Francesco Epifano ◽  
Vito Alessandro Taddeo ◽  
Salvatore Genovese ◽  
Francesca Preziuso ◽  
Daniele Fraternale

2012 ◽  
Vol 7 (10) ◽  
pp. 1934578X1200701 ◽  
Author(s):  
Cécile Ribeiro da Silva ◽  
Valérie Michel ◽  
Salvatore Genovese ◽  
Marie-Christine Prévost ◽  
Francesco Epifano ◽  
...  

In this study we investigated the anti- Helicobacter pylori activity of four isopentenyloxycinnamyl derivatives from the Australian shrub Boronia pinnata Sm. (Rutaceae), structurally related to boropinic acid: ( E)-3-(4-(3-methylbut-2-enyloxy)-3,5-dimethoxyphenyl)acrylaldehyde (1), boropinol C (2), boropinal (3) and boropinol A (4). In vitro growth of H. pylori strains 26695 and B128 was analyzed in liquid culture with increasing doses of these compounds. Bacterial morphology was visualized by scanning electron microscopy. The in vivo effects of the two most efficient molecules that reduced bacterial growth in vitro, compounds 3 and 4, were investigated on H. pylori gastric colonization in the mouse model. The presence of these compounds in the bacterial cultures led to alterations of bacterial surface and flagella. In vivo, both compounds 3 and 4 at 250 μM reduced significantly the ability of H. pylori to colonize the gastric mucosa of mice, compared with untreated ones. These data indicate that these natural isopentenyloxycinnamyl derivatives related to boropinic acid can be considered as novel antibacterial agents with anti- H. pylori activity.


Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
M Locatelli ◽  
G Carlucci ◽  
S Genovese ◽  
F Epifano
Keyword(s):  

2011 ◽  
Vol 73 (9-10) ◽  
pp. 889-896 ◽  
Author(s):  
Marcello Locatelli ◽  
Giuseppe Carlucci ◽  
Salvatore Genovese ◽  
Massimo Curini ◽  
Francesco Epifano

2011 ◽  
Vol 21 (2) ◽  
pp. 769-772 ◽  
Author(s):  
Francesco Epifano ◽  
Silvio Sosa ◽  
Aurelia Tubaro ◽  
M. Carla Marcotullio ◽  
Massimo Curini ◽  
...  

2009 ◽  
Vol 64 (1) ◽  
pp. 210-211 ◽  
Author(s):  
E. Touati ◽  
V. Michel ◽  
M. Correia ◽  
L. Menghini ◽  
S. Genovese ◽  
...  

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
F Epifano ◽  
S Genovese ◽  
L Menghini ◽  
S Sosa ◽  
A Tubaro ◽  
...  

ChemInform ◽  
2007 ◽  
Vol 38 (7) ◽  
Author(s):  
Francesco Epifano ◽  
Luigi Menghini ◽  
Rita Pagiotti ◽  
Paola Angelini ◽  
Salvatore Genovese ◽  
...  

2006 ◽  
Vol 1 (12) ◽  
pp. 1934578X0600101 ◽  
Author(s):  
Massimo Curini ◽  
Francesco Epifano ◽  
Salvatore Genovese ◽  
Luigi Menghini ◽  
Donata Ricci ◽  
...  

Boropinic acid and other natural prenyloxycinnamic and benzoic acids were easily synthesized in high yield by a two-step sequence from the corresponding p-hydroxy aromatic acids and were assayed for radical scavenging activity using the DPPH test and for inhibition of enzymatic lipid peroxidation mediated by soybean 5-lipoxygenase. Compared to other acids and to known antioxidant compounds like BHT, Trolox and ascorbic acid, boropinic acid was far more active in the lipoxygenase test (IC50 = 7.6 ng/mL, p < 0.05). The recorded inhibition value suggested that boropinic acid acted as an enzyme inhibitor rather than a mere radical or peroxide scavenger. This hypothesis was confirmed by studying the interaction between boropinic acid and soybean 5-lipoxygenase by molecular modelling techniques.


2006 ◽  
Vol 16 (21) ◽  
pp. 5523-5525 ◽  
Author(s):  
Francesco Epifano ◽  
Luigi Menghini ◽  
Rita Pagiotti ◽  
Paola Angelini ◽  
Salvatore Genovese ◽  
...  

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