scholarly journals Boropinic acid, a novel inhibitor of Helicobacter pylori stomach colonization

2009 ◽  
Vol 64 (1) ◽  
pp. 210-211 ◽  
Author(s):  
E. Touati ◽  
V. Michel ◽  
M. Correia ◽  
L. Menghini ◽  
S. Genovese ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Boropinic Acid

scholarly journals Anti-Helicobacter Pylori Activities of Natural Isopentenyloxycinnamyl Derivatives from Boronia Pinnata

2012 ◽  
Vol 7 (10) ◽  
pp. 1934578X1200701 ◽  
Author(s):  
Cécile Ribeiro da Silva ◽  
Valérie Michel ◽  
Salvatore Genovese ◽  
Marie-Christine Prévost ◽  
Francesco Epifano ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Antibacterial Agents ◽  
Bacterial Surface ◽  
Bacterial Cultures ◽  
Bacterial Morphology ◽  
Boropinic Acid ◽  
H Pylori ◽  
In Vivo Effects

In this study we investigated the anti- Helicobacter pylori activity of four isopentenyloxycinnamyl derivatives from the Australian shrub Boronia pinnata Sm. (Rutaceae), structurally related to boropinic acid: ( E)-3-(4-(3-methylbut-2-enyloxy)-3,5-dimethoxyphenyl)acrylaldehyde (1), boropinol C (2), boropinal (3) and boropinol A (4). In vitro growth of H. pylori strains 26695 and B128 was analyzed in liquid culture with increasing doses of these compounds. Bacterial morphology was visualized by scanning electron microscopy. The in vivo effects of the two most efficient molecules that reduced bacterial growth in vitro, compounds 3 and 4, were investigated on H. pylori gastric colonization in the mouse model. The presence of these compounds in the bacterial cultures led to alterations of bacterial surface and flagella. In vivo, both compounds 3 and 4 at 250 μM reduced significantly the ability of H. pylori to colonize the gastric mucosa of mice, compared with untreated ones. These data indicate that these natural isopentenyloxycinnamyl derivatives related to boropinic acid can be considered as novel antibacterial agents with anti- H. pylori activity.

In vitro inhibitory activity of boropinic acid against Helicobacter pylori

2006 ◽  
Vol 16 (21) ◽  
pp. 5523-5525 ◽  
Author(s):  
Francesco Epifano ◽  
Luigi Menghini ◽  
Rita Pagiotti ◽  
Paola Angelini ◽  
Salvatore Genovese ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Inhibitory Activity ◽  
Boropinic Acid

In vitro Inhibitory Activity of Boropinic Acid Against Helicobacter pylori.

ChemInform ◽  
2007 ◽  
Vol 38 (7) ◽  
Author(s):  
Francesco Epifano ◽  
Luigi Menghini ◽  
Rita Pagiotti ◽  
Paola Angelini ◽  
Salvatore Genovese ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Inhibitory Activity ◽  
Boropinic Acid

The rod-to-coccoid body transformation in cultures of Helicobacter pylori

1990 ◽  
Vol 48 (3) ◽  
pp. 626-627
Author(s):  
A. R. Crooker ◽  
W. G. Kraft ◽  
T. L. Beard ◽  
M. C. Myers
Keyword(s):  
Helicobacter Pylori ◽  
Growth Cycle ◽  
Negative Bacterium ◽  
Body Formation ◽  
Coccoid Form ◽  
Spiral Form ◽  
Prolonged Culture ◽  
H Pylori ◽  
Upper Gastrointestinal

Helicobacter pylori is a microaerophilic, gram-negative bacterium found in the upper gastrointestinal tract of humans. There is strong evidence that H. pylori is important in the etiology of gastritis; the bacterium may also be a major predisposing cause of peptic ulceration. On the gastric mucosa, the organism exists as a spiral form with one to seven sheathed flagella at one (usually) or both poles. Short spirals were seen in the first successful culture of the organism in 1983. In 1984, Marshall and Warren reported a coccoid form in older cultures. Since that time, other workers have observed rod and coccal forms in vitro; coccoid forms predominate in cultures 3-7 days old. We sought to examine the growth cycle of H. pylori in prolonged culture and the mode of coccoid body formation.

DYSPEPSIA SYNDROME AND HELICOBACTER PYLORI INFECTION IN END STAGE RENAL FAILURE

2000 ◽  
Vol 15 (12) ◽  
pp. H2-H2
Author(s):  
IS Mertasudira ◽  
JR Saketi ◽  
A. Djumhana ◽  
J. Widjojo ◽  
SA Abdurachman
Keyword(s):  
Renal Failure ◽  
Helicobacter Pylori ◽  
Helicobacter Pylori Infection ◽  
End Stage Renal Failure ◽  
End Stage

Mouse model of gastric infection with cytotoxin-expressing strain of Helicobacter pylori in studying of pathogenesis of chronic gastric ulcer

1998 ◽  
Vol 13 (11-s4) ◽  
pp. S178-S184 ◽  
Author(s):  
PETER KONTUREK ◽  
TOMASZ BRZOZOWSKI ◽  
STANISLAW KONTUREK ◽  
ELZBIETA KARCZEWSKA ◽  
ROBERT PAJDO ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Ulcer ◽  
Mouse Model ◽  
Chronic Gastric Ulcer

HEMATEMESIS AND MELENA IN BABY WITH HELICOBACTER PYLORI INFECTION

2000 ◽  
Vol 15 (12) ◽  
pp. H10-H11
Author(s):  
Budi Purnomo ◽  
Eva J. Soeleman ◽  
Hadjat S. Digdowirogo ◽  
Hartati N. Soehardjo
Keyword(s):  
Helicobacter Pylori ◽  
Helicobacter Pylori Infection
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