Studi kasus: Canine chronic ulcerative stomatitis pada anjing Pomeranian

Chronic inflammation of the oral cavity accompanied by ulcers called Canine Chronic Ulcerative Stomatitis (CCUS). A Pomeranian dog was examined at the Animal Hospital, Faculty of Veterinary Medicine, Udayana University with complaints of decreased appetite and drinking accompanied, in the dog that would not close his mouth. Clinical examination showed that there is bleeding and swelling of the gums and lips, torn sores and ulcer on the lower lip, redness on the edge of the tongue, blackish plaque in almost all of his teeth, halitosis, and enlargement of the mandibular lymph nodes, and routine hematological examination showed a normochromic and normocytic anemia, elevated monocyte levels, and neutrophilia, so dogs were diagnosed with CCUS. Treatment using Amoxicillin, Meloxicam, Vitamin C, Ferrous Sulfate, and fluid therapy using NaCl initially gave quite good results, but the dog died on the sixth day after therapy which possibly due to severe malnutrition and anemia.

Characterization of the Oral Microbiome in Canine Chronic Ulcerative Stomatitis

Canine chronic ulcerative stomatitis is a debilitating, oral mucosal disorder of dogs. A commonly held hypothesis for pathogenesis is that bacterial plaque on tooth surfaces is responsible for the ulcerative mucosal lesions. As such, therapy has focused on full-mouth, tooth extraction. Recent studies revealed a unique leukocyte profile in canine ulcerative stomatitis that is amenable to immune modulating therapy. What remains unknown is the role bacteria may play in dysbiosis and immune-inflammatory mechanisms. The microbiota of canine ulcerative stomatitis has not been characterized. Aims of the present study include determination of the microbiome of mucosal lesions in canine ulcerative stomatitis and that of the supragingival plaque of the opposing tooth. The microbiota of these surfaces was compared to healthy mucosa in the canine ulcerative stomatitis patient, and three non-stomatitis control patients. Our hypothesis was that specific microbial species or complexes are associated with ulcerative stomatitis. DNA from 100 clinical samples was evaluated using Next Generation Sequencing methods and was analyzed using LDA Effect Size and the non-parametric factorial Kruskal-Wallis sum-rank test. Statistically significant differences in species were determined from mucosal ulcers versus normal sites in ulcerative stomatitis patients. Species that were more prevalent on the ulcer lesions included putative periodontal pathogens, such as a Tannerella forsythia-like phylotype and Porphyromonas gingivicanis, a species related to the human pathogen Porphyromonas gingivalis. The microbial profile of the supragingival plaque of the abutting tooth to the ulcer revealed similar pathogens. This study showed that in dogs with stomatitis, the mucosal ulcer is inhabited by a unique, species-specific bacterial community and suggests significant differences between the oral mucosa of healthy dogs, dogs with severe periodontal disease, or dogs with oral mucosal tumors. Based on our results, full-mouth, tooth extraction may not be the optimal treatment of the disease.

Extracts of Ficusgibboseblame and its potentiating effect for type II diabetes in rats

HydroalcoholicextractofGreeneriesandstalkbarkofFicusgibbosaBlume is evaluated for their potentiating action in Streptozotocin – Nicotinamide encouraged type 2 diabetes in Sprague Dawley rats. The excerpts are managed at the amount of 100, 250 and 500 mg/kg body weight along with sub operative dose (2.5 mg/kg body weight) of the standard antidiabetic drug (Glibenclamide) for a period of 5 weeks. The test extracts potentiated the antidiabetic activity of standard drug by significantly dropping the raised blood glucose levels and the effect was almost comparable with solitary efficacy of therapeutic dose (5 mg/kg body weight) of typical drug Glibenclamide during 5th week of the study. Its abandons have deviated, on the other hand, orchestrated and more gibbose in those end. The juice of the bark furthermore abandons from claiming color fig alternately bumped fig plant is utilized to grinding those pills furthermore settling on A decoction in toxicology. Plant appeases diminished Kapha, pitta, skin diseases, ulcers, hepatopathy, diabetes, ulcerative stomatitis, leucorrhoea and gynaecological issues. Male Sprague Dawley Rats abstainedinstantare vaccinated intraperitoneally with result about Nicotinamide at a dosage of 195 mg /kg body weight. 15 minutes after same animals are vaccinated for the newly readied result from claiming Streptozotocin (STZ) In measurement about (65 mg/kg physique weight) intraperitoneally. The animals are permitted to drink 1% glucose result instant will succeed the pill prompted hypoglycaemia.

Necrotizing ulcerative stomatitis mimicking erythema multiforme pada pasien dengan HIV seronegatif

ABSTRAKPendahuluan: Necrotizing ulcerative stomatitis (NUS) merupakan inflamasi akut yang ditandai destruksi, ulserasi serta nekrosis epitel, jaringan ikat dan papila. Umumnya terjadi pada pasien malnutrisi dan Human Immunodeficiency Virus (HIV) seropositif. Lesi awal berupa necrotizing gingivitis kemudian berkembang menjadi necrotizing periodontitis, selanjutnya menjadi NUS. Gambaran klinis kasus NUS kadang serupa dengan Erythema multiforme (EM), sehingga perlu dilakukan pemeriksaan penunjang yang dapat menegakkan diagnosa dengan tepat. Tujuan laporan kasus ini melaporkan cara menegakkan diagnosis NUS yang menyerupai EM secara tepat pada pasien dengan suspek infeksi HIV. Laporan kasus: Pasien laki-laki berusia 49 tahun dirujuk ke departemen Ilmu Penyakit Mulut dengan diagnosis EM disertai suspek terinfeksi HIV. Keluhan utama berupa rasa nyeri disertai sariawan pada lidah dan bibir bagian dalam. Pemeriksaan ekstraoral tidak ada kelainan, pada intraoral ditemukan ulser multipel dilapisi sloughing kekuningan pada mukosa labial, mukosa bukal, dorsal lidah, lateral lidah dan ventral lidah. Gingiva anterior rahang bawah terdapat lesi ulseratif disertai jaringan nekrosis. Pemeriksaan darah menunjukkan penurunan hematokrit, peningkatan leukosit, serta negatif pada pemeriksaan tes HIV. Actinomyces naeslundii ditemukan pada pemeriksaan mikrobiologi. Ditegakkan diagnosis NUS dan terapi yang diberikan amoxicillin 500mg, metronidazol 500mg, chlorhexidine gluconate 0,2% dan asam folat. Lesi oral mengalami perbaikan dalam 2 minggu. Simpulan: Lesi oral mengalami perbaikan secara signifikan setelah kontrol ketiga atau seminggu dari kunjungan pertama, pasien sudah dapat makan tanpa rasa nyeri. Gambaran klinis lesi mukosa oral yang khas, serta pemeriksaan penunjang mikrobiologi berperan dalam menunjang diagnosis NUS. Tes HIV perlu dilakukan untuk mengkonfirmasi status infeksi HIV pada pasien. Dokter gigi sebaiknya mengenali tanda dan gejala NUS, sehingga dapat menegakkan diagnosis dan memberikan terapi adekuat serta mencegah meluasnya kerusakan jaringan.

Ulcerative Stomatitis as the Sole Manifestation of Progesterone Hypersensitivity

Oral mucosal involvement of autoimmune progesterone dermatitis is exceedingly rare. This report presents a woman with very painful ulcerative stomatitis that recurred with every menstrual period, in the absence of other clinical manifestations. Ulcers were eventually controlled with oral tamoxifen treatment for three months. Subsequent follow-up visits showed complete resolution of her oral ulcerative lesions. The nonspecific nature of her oral ulcers resulted in multiple medical and dental consultations and a delay in reaching the final diagnosis. Clinicians should be aware of the possibility of progesterone hypersensitivity when painful oral ulcerative lesions appear concurrently with each progesterone surge.