extrinsic skin aging
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F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 1520 ◽  
Author(s):  
Uwe Wollina

Seborrheic keratosis (SK) is a common benign epidermal tumor with predominance in adult patients. Whereas common SKs are more frequent in Caucasians, dermatosis papulosa nigra is more prevalent in patients with a Fitzpatrick skin type of at least 3. There seems to be a link between extrinsic skin aging and the occurrence of SK. Mutations of fibroblast growth factor receptor 3 and other signaling molecules are a frequent finding in SK lesions. However, this does not translate into any malignant potential. Viral infections are particularly common in genital lesions, although their pathogenetic relevance for SK is questionable. Different histologic and clinical subtypes have been identified. The great variability of SKs raises some difficulties in diagnosis. Dermoscopy is the preferred non-invasive diagnostic method, in particular to differentiate pigmented SKs from other pigment tumors, including cutaneous melanoma. Eruptive SKs can be a paraneoplastic condition known as the Leser–Trélat sign. New targeted cancer treatments can cause a pseudo-Leser–Trélat sign. The treatment in practice is mainly minor surgery, including cryosurgery, shave excisions, and laser-assisted removal. The medical approaches have only limited effects. Recently, two formulations for topical therapy have been evaluated: a product with 40% hydrogen peroxide (HP40) and an aqueous nitric–zinc complex. Based on clinical trials, HP40 seems to be a promising alternative to surgery, in particular for facial lesions.


2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Martha Fors ◽  
Santiago Palacios ◽  
Kirsten Falcon ◽  
Karla Ventimilla ◽  
Lilia Simbaña ◽  
...  

2018 ◽  
Vol 2018 (1) ◽  
Author(s):  
Kateryna B Fuks ◽  
Anke Huels ◽  
Dorothee Sugiri ◽  
Jan Goebel ◽  
Ilja Demuth ◽  
...  

2018 ◽  
Vol 2017 (1) ◽  
pp. 305
Author(s):  
Kateryna Fuks ◽  
Anke Hüls ◽  
Dorothee Sugiri ◽  
Andrea Vierkötter ◽  
Jan Goebel ◽  
...  

Author(s):  
Georgios Nikolakis ◽  
Evgenia Makrantonaki ◽  
Christos C. Zouboulis

AbstractAged skin exhibits disturbed lipid barrier, angiogenesis, production of sweat, immune functions, and calcitriol synthesis as well as the tendency towards development of certain benign or malignant diseases. These complex biological processes comprise endogenous and exogenous factors. Ethnicity also markedly influences the phenotype of skin aging. The theories of cellular senescence, telomere shortening and decreased proliferative capacity, mitochondrial DNA single mutations, the inflammation theory, and the free radical theory try to explain the biological background of the global aging process, which is mirrored in the skin. The development of advanced glycation end-products and the declining hormonal levels are major factors influencing intrinsic aging. Chronic photodamage of the skin is the prime factor leading to extrinsic skin aging. The deterioration of important skin functions, due to intrinsic and extrinsic aging, leads to clinical manifestations, which mirror several internal age-associated diseases such as diabetes, arterial hypertension and malignancies.


2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Borut Poljšak ◽  
Raja Dahmane

2010 ◽  
Vol 130 (12) ◽  
pp. 2719-2726 ◽  
Author(s):  
Andrea Vierkötter ◽  
Tamara Schikowski ◽  
Ulrich Ranft ◽  
Dorothea Sugiri ◽  
Mary Matsui ◽  
...  

2010 ◽  
pp. P3-31-P3-31
Author(s):  
A Tiganescu ◽  
AE Mayes ◽  
R Hardy ◽  
PM Stewart ◽  
EA Walker

AGE ◽  
2009 ◽  
Vol 31 (4) ◽  
pp. 365-372 ◽  
Author(s):  
Christopher T. Ford ◽  
Michael J. Sherratt ◽  
Christopher E. M. Griffiths ◽  
Rachel E. B. Watson

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