scholarly journals Free Radicals and Extrinsic Skin Aging

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Borut Poljšak ◽  
Raja Dahmane
Keyword(s):  
Free Radicals ◽  
Skin Aging ◽  
Extrinsic Skin Aging

Skin mirrors human aging

2013 ◽  
Vol 16 (1) ◽  
Author(s):  
Georgios Nikolakis ◽  
Evgenia Makrantonaki ◽  
Christos C. Zouboulis
Keyword(s):  
Clinical Manifestations ◽  
Skin Aging ◽  
Immune Functions ◽  
Free Radical Theory ◽  
Radical Theory ◽  
Glycation End Products ◽  
Aged Skin ◽  
Exogenous Factors ◽  
Major Factors ◽  
Extrinsic Skin Aging

AbstractAged skin exhibits disturbed lipid barrier, angiogenesis, production of sweat, immune functions, and calcitriol synthesis as well as the tendency towards development of certain benign or malignant diseases. These complex biological processes comprise endogenous and exogenous factors. Ethnicity also markedly influences the phenotype of skin aging. The theories of cellular senescence, telomere shortening and decreased proliferative capacity, mitochondrial DNA single mutations, the inflammation theory, and the free radical theory try to explain the biological background of the global aging process, which is mirrored in the skin. The development of advanced glycation end-products and the declining hormonal levels are major factors influencing intrinsic aging. Chronic photodamage of the skin is the prime factor leading to extrinsic skin aging. The deterioration of important skin functions, due to intrinsic and extrinsic aging, leads to clinical manifestations, which mirror several internal age-associated diseases such as diabetes, arterial hypertension and malignancies.

scholarly journals Comparison of Antiaging and Antioxidant Activities of Protocatechuic and Ferulic Acids

2020 ◽  
Vol 4 (2) ◽  
pp. 68 ◽  
Author(s):  
Ermi Girsang ◽  
I Nyoman Ehrich Lister ◽  
Chrismis Novalinda Ginting ◽  
Maulidwina Bethasari ◽  
Annisa Amalia ◽  
...  
Keyword(s):  
Free Radicals ◽  
Ferulic Acid ◽  
Protocatechuic Acid ◽  
Antioxidant Activities ◽  
Skin Aging ◽  
Inhibition Activity ◽  
Extrinsic Factors ◽  
Antioxidant Power ◽  
Ferric Reducing Antioxidant Power ◽  
Collagenase Inhibition

Background: Skin-aging is a progressive changes in the skin combine with cumulative extrinsic factors which are mostly caused by free radicals caused by exposure to lots of free radicals molecules from pollutant, wrongly food intake, or too much sun bathing. These free radicals can be tackled by a treatment using antioxidants. Prevention of aging can be done by escalating antioxidant intake. Protocatechuic acid (PCA) and Ferulic acid (FA) have been known for their scavenging properties on free radicals and antiaging activity. Antioxidant and antiaging activity of both compounds have not been compared comprehensively before. Hence, current study was conducted to compare the potential of PCA and FA for their antioxidant and antiaging activities using various methods.Materials and Methods: Antioxidant analysis of PCA and FA was conducted using H2O2 scavenging assay, 2,2’-azinobis-3-ethylbenzo-thiazoline-6-sulfonic acid (ABTS), 2,2-diphenyl-1-picrylhydrazil (DPPH), and ferric reducing antioxidant power (FRAP). Meanwhile, antiaging activities of PCA and FA were examined using inhibitory activities of tyrosinase, collagenase, elastase, hyaluronidase and tyrosinase.Results: IC50 of scavenging activity of ABTS were 125.18 µg/mL (PCA) and 35.55 µg/mL (FA), inhibition activity of collagenase were 126.16 µg/mL (PCA) and 52.85 µg/mL (FA) and inhibition activity of tyrosinase were 246.42 µg/mL (PCA), 253.58 µg/mL (FA).Conclusion: In conclusion, FA has better ABTS scavenging and collagenase inhibition activities compared to PCA. Meanwhile, PCA has better activity of tyrosinase inhibition than FA.Keywords: antioxidant, antiaging, ferulic acid, protocatechuic acid

scholarly journals Potency of Black Soybean (Glycine max (L.) Merr) Extract and Daidzein as Antioxidant and Antihyaluronidase

2019 ◽  
Vol 24 (1) ◽  
pp. 52
Author(s):  
Tandiah Asan ◽  
I Nyoman Ehrich Lister ◽  
Edy Fachrial ◽  
Annisa Amalia ◽  
Wahyu Widowati ◽  
...  
Keyword(s):  
Free Radicals ◽  
Glycine Max ◽  
Aging Process ◽  
Skin Aging ◽  
Active Compounds ◽  
Black Soybean ◽  
Colorimetric Test ◽  
Soybean Extract ◽  
Glycine Max L ◽  
Antioxidant Potency

Black soybean (Glycine max (L.) Merr.) is a plant that is widely planted and consumed in Indonesia. In addition, black soybean has unique content of isoflavones, such as daidzein, which is one of the active compounds that have the effect of fighting free radicals and can inhibit the aging process. The purpose of this study is to analyze the antioxidant potency possessed by black soybean extract (BSE) and daidzeinin inhibiting aging of the skin. The method used is a colorimetric test. The type of antioxidant test used is H2O2 scavenging and inhibiting the activity of the hyaluronidase enzyme for antiaging. BSE has better effectiveness of H2O2 scavenging (IC50: 286.24±11.16 (µg/mL)) than daidzein compound (IC50: 366.16±2.54 (µg/mL)). In the inhibition of hyaluronidase enzyme, the daidzein has more effective activities (IC50: 95.80±3.98 (µg/mL)) compared to BSE (IC50: 152.56±13.98 (µg/mL)). The antioxidant and anti-aging activities possessed by BSE make it possible to be used as a cosmetic ingredient for skin aging therapy.

Role of Herba Pyrolae Essential Oil in Skin Aging and Their Inhibition of Free Radicals

2019 ◽  
Vol 17 (4) ◽  
pp. 457-462
Author(s):  
Ma Lin ◽  
Lin Qirong ◽  
You Ziqing ◽  
Song Yuhua ◽  
Li Zichun
Keyword(s):  
Free Radicals ◽  
Essential Oil ◽  
Underlying Mechanism ◽  
Skin Aging ◽  
Inhibition Mechanism ◽  
Aging Effects ◽  
Tyrosinase Inhibition ◽  
Activity Inhibition ◽  
Mechanism And Kinetics

Essential oil of Herba pyrolae, a Chinese herbal medicine, has been suggested to exhibit anti-aging effects. To understand underlying mechanism, we have examined its effect on inhibition of two free radicals (2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) and tyrosinase. The half maximal inhibitory concentration (IC50) of the essential oil was 0.1045 mg/mL for DPPH, while that for ABTS was 0.3961 mg/mL. In addition, the essential oil inhibited both monophenolase and diphenolase activities of tyrosinase. Further examination of the tyrosinase inhibition mechanism and kinetics showed that the diphenolase activity inhibition by H. pyrolae essential oil was a non-competitive reversible process. These data suggest possible mechanism(s) underlying anti-aging effects of H. pyrolae essential oil.

scholarly journals Recent advances in managing and understanding seborrheic keratosis

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 1520 ◽  
Author(s):  
Uwe Wollina
Keyword(s):  
Viral Infections ◽  
Topical Therapy ◽  
Growth Factor Receptor ◽  
Skin Aging ◽  
Seborrheic Keratosis ◽  
Cancer Treatments ◽  
Promising Alternative ◽  
Non Invasive ◽  
Minor Surgery ◽  
Extrinsic Skin Aging

Seborrheic keratosis (SK) is a common benign epidermal tumor with predominance in adult patients. Whereas common SKs are more frequent in Caucasians, dermatosis papulosa nigra is more prevalent in patients with a Fitzpatrick skin type of at least 3. There seems to be a link between extrinsic skin aging and the occurrence of SK. Mutations of fibroblast growth factor receptor 3 and other signaling molecules are a frequent finding in SK lesions. However, this does not translate into any malignant potential. Viral infections are particularly common in genital lesions, although their pathogenetic relevance for SK is questionable. Different histologic and clinical subtypes have been identified. The great variability of SKs raises some difficulties in diagnosis. Dermoscopy is the preferred non-invasive diagnostic method, in particular to differentiate pigmented SKs from other pigment tumors, including cutaneous melanoma. Eruptive SKs can be a paraneoplastic condition known as the Leser–Trélat sign. New targeted cancer treatments can cause a pseudo-Leser–Trélat sign. The treatment in practice is mainly minor surgery, including cryosurgery, shave excisions, and laser-assisted removal. The medical approaches have only limited effects. Recently, two formulations for topical therapy have been evaluated: a product with 40% hydrogen peroxide (HP40) and an aqueous nitric–zinc complex. Based on clinical trials, HP40 seems to be a promising alternative to surgery, in particular for facial lesions.

High Environmental Ozone Levels and Extrinsic Skin Aging

2018 ◽  
Vol 2018 (1) ◽  
Author(s):  
Kateryna B Fuks ◽  
Anke Huels ◽  
Dorothee Sugiri ◽  
Jan Goebel ◽  
Ilja Demuth ◽  
...  
Keyword(s):  
Skin Aging ◽  
Extrinsic Skin Aging ◽  
Ozone Levels

scholarly journals Exploratory study of the reproducibility of the SCore for INtrinsic and EXtrinsic skin aging (SCINEXA) scale in “Ruta Escondida de la Mitad del Mundo”, Ecuador, 2017

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Martha Fors ◽  
Santiago Palacios ◽  
Kirsten Falcon ◽  
Karla Ventimilla ◽  
Lilia Simbaña ◽  
...  
Keyword(s):  
Exploratory Study ◽  
Skin Aging ◽  
Extrinsic Skin Aging
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