Roles of Oxidative Stress in Policystic Ovary Syndrome

Polycystic ovary syndrome (PCOS) represent a common endocrine disorder that affects nearly 4 to 12 percents of reproductive age women in general population studies (1). PCOS is caracterized by the oligoovulation or anovulation, hyperandrogenisam and multiple small ovarian cysts. The etiology of PCOS is steel unclear. Patophysiology of PCOS represents the complex mehanism. There is a wide spectar of signs and symptoms of the PCOS, which vary in severity over the time and within individuals. Major symptoms are: the amenhorhea, oligomenorhea combined with of episodes of menometrorhagia. Some signs of hiperandrogenism are: acne, hirsutism and alopecia. Other important symptoms of the PCOS are: the obesity, dyslpedemia, insuline resistance, metabolic syndrome, infertility, endometrial neoplasia, pregnancy loss. Diagnosis is achieved by exclusion of other factors that lead to anovulation, and laboratory assay of sex hormones and gonadotropines. One of the novel approaches in evaluation of etiology and pathogenesis of the PCOS recognizes oxidative stress as an important factor in genesis of this syndrome. For investigation of the oxidative stress role in the pathogenesis of diseases, some biochemical markers have been used including the MDA and NO also anti-oxidative biomarkers such as Total Antioxidative Capacity, Superoxide Dismutase, Glutation Peroxidase, and glutathione. Most of recent studies compared the oxidative stress biomarker level or antioxidative biomarkers levels in the PCOS patients and healthy controls. Patients with the PCOS in those studies were often subdivided in groups by the presence of insulin resistance (HOMA index) or infertility or not. One of the main problems in this field of research is inconsistency in precise definition of the PCOS, as well as different expression of various symptoms within individuals over the time. In that manner it is very difficult to follow up these patients and to establish criteria that could be compared in studies.

Perinatal consequences in women with the Polycystic Ovarу Syndrome on a background insuline resistance in anamnesis

In this article features of perinatal consequences in women, pregnancy, which became after the treatment of the Polycystic Ovarу Syndrome on a background of insuline resistance are considered. The clinical and static retrospective analysis of 102 of childbirth histories in women with the Polycystic Ovarу Syndrome in anamnesis is conducted for period from 2009th to 2012th on the base of maternity hospital in Uzhorod. It was found that insuline resistance has negative influence on the state of new-born. The objective: to study the effect of insulin resistance in pregnant women on neonatal status. Patients and methods. Retrospective clinico-statistical analysis of 100 individual cards and stories of labor in patients with polycystic ovary syndrome on the background of insulin resistance and 100 stories of newborns. And the first study group were children of women with PCOS on the background of IR. This is the primary group. And II group (control) took the children of healthy women, whose number was 115. Pregnant women, who were executed in vitro fertilization, the study has not been included. Resalts. The influence of insulin resistance in pregnant women on neonatal status. Established negative its effects on infants, namely an increase in the incidence of perinatal complications. Conclusion. The state of hyperandrogenism and insulin resistance in women with PCOS in history, of course, adversely affects the condition of the newborn: increased risk of asphyxia of the newborn, hypoxic-ischemic encephalopathy, respiratory insufficiency I, II and III degrees, reduced muscle tone. Also increased risk of hypoxic cardiopathy, cardio-respiratory depression and the courts. Key words: pregnancy, polycystic ovary syndrome, insulin resistance, newborn.