Pathomorphology of cat pancreas under chronic pancreatitis

The paper deals with studying the pathomorphology of cat pancreas under chronic pancreatitis. This paper is a component of a research mix of the Department of Anatomy and Histology, it goes under the title “The development, morphology and histo-chemistry of animal organs in health and in disease”, (state registration number № 0120U100796). A pancreas is an azygos parenchymatous organ which refers to the endoexocrine glands, includes exocrine and endocrine pancreas, is involved in the processes of digestion and regulation of carbohydrate metabolism, protein metabolism and lipid exchange in tissues. Pancreatic juice, which is rich in enzymes (trypsin, lipase, amylase), is produced in an exocrine pancreas, and hormones (insulin, somatostatin, glucagon (vasoactive intestinal polypeptide), pancreatic polypeptide) are produced in endocrine pancreas. This galand is involved in the process of digestion while producing digestive enzymes, which get into the duodenum and hydrolyze practically all parts of feeds which enter the body. It is located in an abdominal cavity, anatomically connected with a stomach, liver and duedenum. It has been found that pathomorphological changes in pancreas under chronic pancreatits manifest themselves depending on the disease stage and are revealed by insignificant progress of the pathological process. Herewith, morphological parameters of pancreas width and length in cats under chronical pancreatitis did not significantly change, but these indices tended to decrease. Its absolute weight in cats under chronical pancreatitis, as compared with clinically healthy cats, did not change and equalled 9.12 ± 2.03 g. But pancreas relative weight in sick cats increased by 1.4 (Р ≤ 0.01) and equalled 0.51 ± 0.08 %, as compared with control 0.38 ± 0.06 %. Under histological analysis of pancreas histology specimen stained with hematoxylin Corazzi and eosin, some distortion in a microscopic structure of a pancreas was observed, it manifested itself in thickening of interparticle tissue-connective layers which spread like desmogenous bands. Some destructive changes in acini in exocrinal pancreas, which manifested themselves in losing their characteristic form, were noticed. The cytoplasm of such acinous cells was in a state of plasmorrhexis, the pycnosis was observed.

PAIN SYNDROM IN CASES OF PATIENTS WITH A COMBINATION OF CHRONIC PANCREATITIS AND HYPERTENSION: RELATIONSHIPS, INTERACTIONS, CORRECTION

The aim: To identify the relationships and interactions of the pain development in cases of patients with a combination of Chronic Pancreatits and Arterial Hypertension, with the next correction Materials and methods: We have conducted a comprehensive examination of 102 patients with a diagnosis of Chronic Pancreatitis in combination with stage II Arterial Hypertension during 2018-2020. The investigative contingent was divided by two study groups which depended from the treatment regimen. The first (I) group (n = 53) received basic therapy (BT) in accordance with the requirements of the relevant clinical protocols; the treatment of the second (II) group (n = 49) included the basic therapy with optimization (OT) by mineralocorrection (Zinc, Selenium, which have antioxidant properties), ω-3 polyunsaturated fatty acids and Folic Acid. The therapy duration was 8 weeks. Results: The performed regression analysis was mathematically substantiated the influence of the studied laboratory parameters of the inflammatory response and antioxidant system on the formation, dynamics of abdominal pain (the main clinical sign of CP) and the value of PAP (hypertensive vascular remodeling marker and risk predictor of cardiovascular events). The severity of abdominal pain is significantly influenced by leukocytes, ESR, α1-AT, cortisol, CRP, Bilirubin and Urea, and the value of PAP – CRP and selenium, from laboratory parameters of the inflammatory response and AOS, Conclusions: The effectiveness of the assigned optimized treatment scheme has been proven, which is indicated by the appearance of a reliable regression coefficient on the parameter of glutathione peroxidase after completion of treatment in comparison with patients used basic therapy