68Ga-FAPI PET/MR is Helpful in Differential Diagnosis of Pancreatitis From Pancreatic Malignancy Compared to 18F-FDG PET/CT

Background: 68Ga-fibroblast activation protein specific enzyme inhibitor (FAPI) is a novel PET agent for tumor imaging. Case description: We herein present a case where 68Ga-FAPI PET/MR helped to diagnose IgG4-RD that involved pancreas and bile duct. Our 62-year-old patient suffered from middle upper abdomen and brown urine. Blood test revealed abnormal liver function and elevated IgG4 (4.830g/L↑). 18F-FDG PET showed enlarged uncinate process and dilated bile duct tree. Mild increase of FDG uptake in uncinate process and head of pancreas indicated possible pancreatic malignancy, but the evidence was not sufficient enough. 68Ga-FAPI PET revealed prominent fibroblast mediated inflammation in the entire pancreas and bile duct, suggesting IgG4-RD.Conclusion: The case illustrates that 68Ga-FAPI PET is more sensitive to IgG4-RD than 18F-FDG, and thus could be helpful in improving the differential diagnosis of pancreatitis and pancreatic cancer.

Gustav Woyer. (From the clinic of Prof. Schauta). - A case of eclampsia in mother and child. - (Centr. F. Gynaec., No. 13, 1895)

The course and therapy of this case is so interesting that I will allow myself to give a detailed abstract of it. 30-year-old, first childbirth, delivered to the clinic in an unconscious state. According to relatives, she had 2 convulsive seizures during the last 2 hours. Soon after arrival, a new one came - the third seizure of convulsions, 5 minutes in duration, characteristic of eclampsia. The pulse rate is about 120 per minute, severe tracheal wheezing, foam at the mouth, deep cyanosis, soporosis. After some time, my condition improved somewhat. Pulse 96 beats, breathing 36 per minute superficial. The catheter was delivered 30 ccm. concentrated, dark brown urine, containing 9 , according to Essbachy, protein, and in the sediment had numerous granular and epithelial casts.

Clinical and pathological findings in a Dwarf Red Brocket Mazama rufina (Mammalia: Cetartiodactyla: Cervidae) attacked by dogs

Capture myopathy is a common fatal syndrome in wild ungulates resulting from anthropogenic stressful events such as the capture or transport of specimens. There are, however, few published data on this issue due to predator attacks. The present report describes for the first time the capture myopathy syndrome in a Dwarf Red Brocket Mazama rufina following dog Canis familiaris attack. Clinical signs included pale mucous with increase capillary refill time, tachycardia, tachypnea, hypertension, hypothermia, hypoglycemia, and red brown urine. Muscle tremors, ataxia, prostration, paralysis, and opisthotonus were progressively observed. Laboratory tests showed increased levels of cortisol, creatinine, creatine kinase, lactate dehydrogenase, and potassium; decreased blood urea nitrogen-creatinine ratio; and myoglobinuria. The animal died 72 hours after hospital admission. At necropsy, findings included injuries on both hindlimbs with edema, emphysema, and soft-friable texture in affected muscles, dark kidneys and brown urine in bladder. Histopathological exams were indicative of skeletal-cardiac muscle degenerative lesions and myoglobinuric nephrosis. Immuno-histochemistry revealed myoglobin depletion in degenerate muscles and myoglobin accumulation in renal tissues. We strongly recommend that treatment for capture myopathy be initiated when a wild ungulate is admitted with history of predator attack, since the syndrome may have already established. This report adds to the instances of negative impacts caused by domestic dogs on threatened wildlife species.

Acute renal failure in a horse following bee sting toxicity

ABSTRACT: Bee envenomation is frequent in humans and dogs, but uncommon in horses. This study aimed to describe a case of acute renal failure following mass envenomation in a horse. A mare was attacked by a swarm of bees and showed reluctance to move, epistaxis, and dark-brown urine. Biochemical exams revealed increase in urea and creatine serum levels. The mare did not respond to treatment and euthanasia was elected after four days of clinical course. At the necropsy, there were multifocal pinpoint to elevated skin lesions associated with edema and hemorrhage, which extended to the subcutaneous tissue and skeletal muscle, and the kidneys were diffusely dark-brown and friable. Microscopically, renal tubules were distended and filled with an orange-red, hyaline globular material, and had severe epithelial tubular cell necrosis. The diagnosis was established based on clinical and histological analysis, and pathological evaluation was essential to confirm acute renal failure due to bee sting toxicity.

Rhabdomyolysis and acute kidney injury in the deceased donor: a case report

Rhabdomyolysis is a common complication among brain death donors, affecting the number of organ donations and the quality of donor kidneys. Case report: Male, 17 years old, admitted to the hospital due to a car accident. Subsequently, brown urine appeared, blood myoglobin increased significantly, urine output decreased, and renal function impaired. Treatments including fluid replacement, alkalization of urine, plasma exchange and bedside CRRT were given. The patient's renal function recovered, and the organs were successfully acquired. The renal function recovered well after transplantation. Conclusion: Attention should be paid to rhabdomyolysis. Early diagnosis and treatment of patients with brain death could improve donation success rate and the recovery of postoperative renal function.

Ureamic Syndrome in Theileria Equi-Infected Argentine Polo Pony: A Case Report.

On June 26th, 2016, an 8-year old Argentine Polo Pony in the Fifth Chukker Polo and Country Resort, Maraban Jos, Igabi Local Government Area of Kaduna State, Nigeria was reported with the chief complaint of anorexia, depression, recurrent recumbency, colic and pyrexia. Physical examination revealed the following signs; pyrexia, tachypnoea and rapid pulse rates, bilateral epiphora as well as icteric ocular, gingival and vaginal mucous membranes, 5% dehydration, trembling, sweating, colic, body condition score of 3/5, reddish brown urine and tick infestation (identified as Rhipicephalus spp). Blood was collected via jugular venipuncture into vacutainer containing ethylenediamine tetraacetic acid (EDTA) for microscopic and haematological analyses while a second aliquot was transferred into plain vacutainer for biochemical analysis. Giemsa stained thin blood smear revealed the presence of Theileria equi haemogram revealed normocytic hypochromic anaemia with thrombocytopaenia. The biochemical analysis showed decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) levels, hyperproteinaemia, hyperglobulinaemia, ureamia, hyperkalaemia, hyponatraemia, hypochloraemia and decreased bicarbonate concentration. Based on the presenting clinical signs, presence of ticks and laboratory findings, equine piroplasmosis accompanied by ureamic syndromewas diagnosed..