Twitter as a Medical Media Among French Young Oncologists: Results from a National Survey

Since its launch in 2006, Twitter has become a commonly used platform for sharing medical information, especially in the field of oncology. However, its role and impact on young oncologists’ education remain unclear. Moreover, COVID-19 and congress virtualization is likely to have modified Twitter use by the medical society.We conducted a national survey (27 questions) in France among medical oncology, hematology, and radiation therapy young doctors to help better understand the role played by Twitter on their medical education. One hundred eighty-three young oncologists participated in our survey. A majority does not use Twitter (72.1%), mostly to reduce their time spent on social media. Participants using Twitter (27.9%) often use it more than once a week, mostly by scrolling on their news feed. Interestingly, they rarely express their own opinion on Twitter: a majority of them (75.5%) tweet less than once a month while the rest of them mostly retweet others’ tweets. They mainly follow English-speaking experts, scientific societies, and medical journals. Pharmaceutical laboratories’ accounts are of less significance. Overall Twitter usage seems increasing since COVID-19 pandemic and the consequent digitalization of congresses. No statistical difference was observed between the baseline characteristics of Twitter users and non-users.This survey shows that Twitter is a relevant mean of continuous medical education used by around a third of French young oncologists, especially since COVID-19 pandemic and the virtualization of congresses. This media should be considered and evaluated for its educational advantages or potential biases.

AB0698 CORONAVIRUS 19 DISEASE VACCINE: PERCEPTIONS AND INTENTIONS OF TUNISIAN PATIENTS WITH RHEUMATOID ARTHRITIS

Background:Coronavirus disease 2019 (covid-19) has now spread to millions of persons worldwide to become a global pandemic. Covid-19 is asymptomatic for some individuals and for others it can cause symptoms ranging from flu-like to acute respiratory distress syndrome, pneumonia and death. Several vaccine candidates are now available, and patients with chronic inflammatory disease such as rheumatoid arthritis (RA) are encouraged to get vaccinated.Objectives:The aim of this study was to determine perceptions of RA patients about the covid-19 vaccine.Methods:We conducted a cross-sectional study including Tunisian patients with RA (ACR/EULAR 2010). Demographic and disease parameters were collected: age, gender, educational status, disease duration, erythrocyte sedimentation rate (ESR), disease activity score (DAS28), and treatments being used. All patients responded to a questionnaire on their perceptions and concerns about the covid-19 vaccine, and whether they intended to get vaccinated or not. A p value inferior to 0.05 was considered significant.Results:We included 54 patients (45 women and nine men) with a mean age of 55±11 years old [23-69]. Thirty-one percent of patients were illiterate. The mean disease duration was 9.9±5.9 years [0-20]. The mean DAS28 ESR was 4.68±1.35 [1.50-7.16].NSAIDs were used in 13% of patients, corticosteroids in 63% of patients at a mean daily dose of 8mg [2.5-20] of prednisone equivalent, methotrexate in 63% of patients, sulphasalazine in 13% of patients, leflunomide in 3.7%, and biologics in 22.2% of patients.None of these patients had contracted the covid-19. Seventeen percent of patients had been in close contact with someone positive for the disease. All the patients reported that they respected the preventive measures. Fifteen percent of patients had stopped their treatment because they were afraid of the covid-19: Methotrexate (n=4), sulphasalazine (n=1), tocilizumab (n=2), and rituximab (n=1).More than half of patients (67.7%) reported that they didn’t want to get vaccinated against covid-19. The reasons given by these patients were: presumed adverse events (100%), religious beliefs (86.7%). presumed inefficiency (83.3%), no recommendation from their doctor (80%), fear that the vaccine would interact with their treatment (76.7%), lack of trust in the pharmaceutical laboratories (76.7%), fear from vaccines in general (53.3%), fear that the vaccine would make RA worse (50%), and presumed overprice of the vaccine (30%).A significant association was noted between educational status and, religious beliefs (p=0.001), lack of trust in the pharmaceutical laboratories (p=0.007), fear that the vaccine would make RA worse (p=0.008) or interact with other treatments (p=0.022), and presumed overprice of vaccine (p<0.001).Conclusion:Most of RA patients expressed their unwillingness to get vaccinated against covid-19. Doubts about the vaccine’s efficiency and security and religious beliefs were the main reasons for this choice.Disclosure of Interests:None declared

Hotplace Magnetic Stirrer Automatic Heat Control and Water Velocity Based on PID (Proportional Integral Derivative)

Hotplate magnetic stirrer is a laboratory tool that is used to heat or warm as well as mix or homogenize chemical solutions. This tool is available in chemical, microbiology and pharmaceutical laboratories. Equipped with a stirrer made of magnets (stir bar) which is used to homogenize chemical solutions. This magnetic stirrer hotplate uses an ATMega 16 microcontroller based system. It uses an infrared temperature sensor MLX90614 to measure and monitor the temperature of the solution, starting from the start of mixing which is assisted by rotating a DC motor as a stirring device until the liquid is mixed or homogeneous. Homogeneous conditions are indicated by the ADC value ( Analog to Digital Convertion) which is obtained constant. If you use the automatic menu, only choose the mixing solution on the automatic menu. There are four choices for the solution speed of 400-1600 rpm with an increase of 400, there are four temperature choices, namely 30-60 degrees Celsius in increments of 10, there is a choice of time used for stirring time at 1-30 minutes. For temperature display, stirring speed and stirring time can be seen on the LCD 20x4 display.

Construction of EH&S Management System in Pharmaceutical Laboratories in University

Pharmaceutical science is an experimental subject involving many disciplines. As there are different kinds of risky factors, more and more attentions have been paid to the safety management of pharmaceutical laboratories. The article analyzes the deficiency of current safety management of pharmaceutical laboratories in domestic universities, draws on the EH&S management model of universities in developed countries and explores measures to construct an EH&S management system for pharmaceutical laboratories in domestic universities.

Cyclodextrin-Based Functional Glyconanomaterials

Cyclodextrins (CDs) have long occupied a prominent position in most pharmaceutical laboratories as “off-the-shelve” tools to manipulate the pharmacokinetics of a broad range of active principles, due to their unique combination of biocompatibility and inclusion abilities. The development of precision chemical methods for their selective functionalization, in combination with “click” multiconjugation procedures, have further leveraged the nanoscaffold nature of these oligosaccharides, creating a direct link between the glyco and the nano worlds. CDs have greatly contributed to understand and exploit the interactions between multivalent glycodisplays and carbohydrate-binding proteins (lectins) and to improve the drug-loading and functional properties of nanomaterials through host–guest strategies. The whole range of capabilities can be enabled through self-assembly, template-assisted assembly or covalent connection of CD/glycan building blocks. This review discusses the advancements made in this field during the last decade and the amazing variety of functional glyconanomaterials empowered by the versatility of the CD component.

PENILAIAN KINERJA MELALUI WORK PERFORMANCE KARYAWAN PT. KONIMEX PHARMACEUTICAL LABORATORIES

This study used a quantitative approach. Respondents were employees of PT Konimex Pharmaceutical Laboratories. Technique sampling were used at this study was accidental sampling. The number of samples obtained was 175 respondents. Data analysis techniques using the PAWS Statistics Program 18. Hypothesis testing used Multiple Linear Regression Test which includes t test, F test, and the coefficient of determination. The results showed that: (1) functional structure had a significant effect on employee work performance; (2) incentive policies significantly influence employee work performance; (3) work culture has a significant effect on employee work performance; (4) functional structure, incentive policy, and work culture simultaneously affect the work performance of employees of PT Konimex Pharmacutical Laboratories. Keywords: Functional Structure, Incentive Policy, Work Culture, Work Performance

Determination of Genotoxic alkyl p-toluene Sulfonates in Cabazitaxel using LC-MS Method

Introduction: A suitable LC-MS method for the quantitative determination of genotoxic impurities such as alkyl p-toluene sulfonates in Cabazitaxel was developed. Alkyl p-toluene sulfonates were estimated by LC-MS method using Waters Symmetry C18 (75×4.6 mm), 3.5 µ column. Materials and Methods: Column temperature was maintained 40 °C. Injection volume was 10 µL and flow rate was set as 0.8 mL/min. Sampler temperature was maintained to 25 °C and run time was set as 25 minutes. The mobile phase was a mixture of ammonium acetate buffer and acetonitrile in 70:30(v/v) was used. Results: The method validation has been carried as per ICH guidelines. LOQ was found to be 2.66 µg/mL, 2.75 µg/mL and 2.55 µg/mL for MPTS, EPTS and IPPTS Alkyl p-Toluene Sulfonates (APTS) respectively. Conclusion: The proposed Liquid chromatography-Mass spectroscopy method that can quantify genotoxic APTS in Cabazitaxel at low-level concentration has been developed and validated as per ICH guidelines. Hence, the proposed method was recommended for the assay of genotoxic impurities of cabazitaxel in dosage forms in busy pharmaceutical laboratories.

Desarrollo de una superficie de Fresnel tipo canal usando un LED de alta potencia para adaptarlo a un reactor fotoquímico

A channel-type Fresnel surface was designed using the polynomial interpolation adjustment method. The experimental arrangement was composed of a metal complex, a high power LED lighting source, a cooling system and a Fresnel concentrator. The tests were done in a dark chamber, placing the compound at an effective focal distance from the reflected rays of the concentrator, for a time. By exposing the sample to the LED irradiation, its changes were registered in a UV-Vis spectrophotometer, obtaining an absorbance graph vs wavelength, the changes observed in the transition bands in displacement and intensity of the blue region to the red of the spectrum, confirmed the efficiency and usefulness of the Fresnel-type concentrator in the development of the photochemical reactor. This photochemical reactor has an advantage over commercial reactors, because it uses samples of compounds in small solutions, is portable, it can be implemented in university and pharmaceutical laboratories. The results were favorable, a low energy consumption was obtained, and a reduction of time in the molecular reaction process of the analyzed compound.