vaccinia virus recombinant
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Author(s):  
O. Koval ◽  
G. Kochneva ◽  
V. Richter

A double recombinant vaccinia virus VV-GMCSF-Lact, producing human GM-CSF and oncotoxic protein lactaptin, was constructed. Preclinical studies of VV-GMCSF-Lact as an antitumor drug for human solid tumors therapy were successfully completed. The drug is recommended for clinical trials.


Parasitology ◽  
2004 ◽  
Vol 128 (4) ◽  
pp. 397-405 ◽  
Author(s):  
J. L. ROQUE-RESNDIZ ◽  
R. ROSALES ◽  
P. HERION

2003 ◽  
Vol 77 (16) ◽  
pp. 9094-9098 ◽  
Author(s):  
Rosa M. Dalton ◽  
Esperanza P. Pastrana ◽  
Alicia Sánchez-Fauquier

ABSTRACT Human astrovirus is an important cause of acute gastroenteritis. We have generated, for the first time, a vaccinia virus recombinant expressing the astrovirus 87-kDa structural polyprotein. The results demonstrate that this expression results in the formation of virus-like particles in the absence of other astrovirus proteins and genomic RNA. The purified trypsin-activated virus-like particles strongly resemble the complete astrovirus particles.


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