gtpase effector domain
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2019 ◽  
Vol 5 (3) ◽  
pp. a003673 ◽  
Author(s):  
Nurit Assia Batzir ◽  
Pranjali K. Bhagwat ◽  
Tanya N. Eble ◽  
Pengfei Liu ◽  
Christine M. Eng ◽  
...  

2018 ◽  
Author(s):  
Sansrity Sinha ◽  
Gopala Krishna Aradhyam

Mitofusin mediate fusion of outer mitochondrial membranes (OMM). Recent studies have explained the role of GTPase domain for Mfn1 dimerization and outer mitochondrial membrane (OMM) fusion. Coiled-coiled domains [namely, coiled-coil/Middle domains (CC1MD) and coiled-coil-2 GTPase effector domain (CC2/GED)] form helical bundles that mediate open-to-close conformations of Mfn1 upon GTP binding and have been previously reported to be important for OMM tethering and OMM fusion. To further decipher the significance of helical structure of MD, we functionally characterized the heptad repeat regions of MD. Consistent with previous studies, we show that MD consists of two heptad repeats (HR1, namely HR1a and HR1b) and both of these are crucial for Mfn1 mediated OMM fusion.


BMC Neurology ◽  
2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Nyamkhishig Sambuughin ◽  
Lev G. Goldfarb ◽  
Tatiana M. Sivtseva ◽  
Tatiana K. Davydova ◽  
Vsevolod A. Vladimirtsev ◽  
...  

Biochemistry ◽  
2014 ◽  
Vol 53 (36) ◽  
pp. 5724-5726 ◽  
Author(s):  
Saipraveen Srinivasan ◽  
Juha-Pekka Mattila ◽  
Sandra L. Schmid

PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e30109
Author(s):  
Swagata Chakraborty ◽  
Supriya Pratihar ◽  
Ramakrishna V. Hosur

2008 ◽  
Vol 3 (1) ◽  
pp. 13-16 ◽  
Author(s):  
Jeetender Chugh ◽  
Shilpy Sharma ◽  
Dinesh Kumar ◽  
Ramakrishna V. Hosur

FEBS Journal ◽  
2006 ◽  
Vol 273 (2) ◽  
pp. 388-397 ◽  
Author(s):  
Jeetender Chugh ◽  
Amarnath Chatterjee ◽  
Ashutosh Kumar ◽  
Ram Kumar Mishra ◽  
Rohit Mittal ◽  
...  

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