Crystallographic and spectroscopic characterization of racemic Mosher's Acid

The title compound, C10H9F3O3, represents the structure of racemic Mosher's Acid (systematic name: 3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid), a carboxylic acid that when resolved can be employed as a chiral derivatizing agent. The compound contains a carboxylic acid group, a methoxy group and a trifluoromethyl substituent on an asymmetric benzylic carbon atom. The two independent molecules in the asymmetric unit form a non-centrosymmetric homochiral dimer via intermolecularly hydrogen-bonded head-to-tail dimers with graph-set notation R 2 2(8) and donor–acceptor hydrogen-bonding distances of 2.6616 (13) and 2.6801 (13) Å.

Supramolecular interaction of non-racemic benzimidazolium based ion pairs with chiral substrates

Benzimidazolium-based non-racemic ionic liquids as chiral recognition agents showed supramolecular interactions between H–C2 of cation and racemic Mosher's acid salts.

A remarkable chiral recognition of racemic Mosher's acid salt by naturally derived chiral ionic liquids using 19F NMR spectroscopy

A new class of d-xylose derived imidazolium-based chiral ionic liquids were designed and synthesized via simple tuning approaches.

Synthesis and applications of secondary amine derivatives of (+)-dehydroabietylamine in chiral molecular recognition

(+)-Dehydroabietylamine (1a), the novel derivatives (2a–6a) and their NTf2 salts (1b–6b) were tested as chiral NMR solvating agents for the resolution of enantiomers of Mosher's acid and other carboxylic acids, and their n-Bu4N salts.

Synthesis and Properties of Novel Chiral Ionic Liquids from L-Proline

A novel class of chiral ionic liquids with chiral cations directly derived from natural l-proline has been synthesized and their physical properties such as melting point, thermal degradation, and specific rotation have been characterized. Further, their potential use in chiral recognition was demonstrated by studying interactions with racemic Mosher’s acid salt.