Total Migration of the Lumbo-peritoneal valve from D4 to V4: Case Report

The valve devices are designed for the treatment of hydrocephalus, Ventriculoperitoneal shunt (VPS) and lumbopperitoneal shunt (LPS), but they have two complications: infectious and mechanical. Among the latter, we find the dysconnection and migrations of parts of the valves either in the intracranial ventricular cavities or in the natural cavities of the patient's body (heart, colon, bladder, lung, vena cava, etc.) even externalization. through natural orifices.

Migration and Asylum Flows to Germany: New Insights Into the Motives

This study analyzes the determinants of both total migration and asylum migration to Germany. For the analysis, a comprehensive empirical model is set up that includes climate change, economic opportunities, such as per capita income differentials, links to Germany, home country characteristics (population growth, poverty, consumer confidence, unemployment), the political and institutional situation in the sending countries (measured by internal and external conflict, ethnic and religious tensions, government stability, law and order, military in politics), and a control for migration opportunities to alternative destinations. Panel data techniques (Poisson pseudo-maximum likelihood) for the estimation of the parameters of interest are employed using a panel of 115 (134) origin countries for asylum migration (total migration) over the period of 1996–2017 or 2001–2017, depending on data availability. The analysis reveals that political, socioeconomic, and economic factors determine both total migration and asylum migration. Economic factors are also determinants of asylum applications, as asylum seekers most often come for several reasons. Poverty plays a distinct role in total migration and asylum migration. An alleviation of poverty in origin countries is associated with less overall migration to Germany but with more asylum migration. Increases in average temperature also impact asylum migration in the expected direction, thus, increasing forced migration. The most interesting findings are revealed when considering country groupings (main migration countries, major asylum countries, countries whose asylum applicants enjoy high, intermediate, or low recognition rates).

MODERN MIGRATION SITUATION IN KRASNODAR REGION

t. Based on statistical data, the article analyzes the transformation of the migration movement of the population of the Krasnodar Territory in the context of natural decline and a pandemic of coronavirus infection. It is shown that in the region, as well as in Russia as a whole, there is a deterioration in demographic development. Due to the excess of the death rate over the birth rate in the region, the natural population decline resumed in 2017, the volume of which increased 8.5 times by 2020. The demographic indicators worsened especially noticeably in 2020, primarily in relation to the mortality rate of the population, the level of which has sharply increased. Despite the deteriorating demographic situation, the number of residents of the Kuban continued to increase, while in the Russian Federation in recent years the absolute population began to decline. An analysis of the components of population change showed that the determining factor in the increase in the number of Kuban residents was migration gain, which not only compensated for the natural decline in the population, but also ensured an increase in the number of inhabitants of the region. It was revealed that significant changes took place in the migration movement of the Krasnodar Territory in the analyzed period: the intensity of migration processes has noticeably decreased, and in recent years, the volume of net migration has also decreased. The region’s contribution to the total migration gains of the Southern Federal District has significantly decreased - in 2020 the region’s share in the total migration growth of the district amounted to only 31.6% versus 78.9% in 2017. The decrease in the volume of net migration was mainly due to a decrease in the number of arrivals to the region, which is not least due to quarantine measures to combat the pandemic

Revealing migratory path, important stopovers and non-breeding areas of a boreal songbird in steep decline

The Olive-sided Flycatcher (Contopus cooperi) is a steeply declining aerial insectivore with one of the longest migrations of any North American passerine. We deployed light-level geolocators and archival GPS tags on breeders in boreal Alaska to determine migratory routes, important stopovers and non-breeding locations. Data from 16 individuals revealed a median 23,555 km annual journey (range: 19,387, 27,292 km) over 95 days (range: 83, 139 days) with wintering occurring in three regions of South America (NW Colombia/Ecuador, central Peru and W Brazil/S Peru). We developed a new method to identify “Important Stopovers” by quantifying intensity of use (a function of bird numbers and stop durations) along migratory routes. We identified 13 Important Stopovers that accounted for ~66% of the annual migratory period, suggestive of refueling activities. Some sites coincided with key areas previously identified for other Neotropical-Nearctic migrants. Percent land “protected” at Important Stopovers, as defined by IUCN, ranged from 3.8% to 49.3% (mean [95% CI]: 17.3% [9.6, 25.0]). Total migration speed did not differ by season (median: 255 km day-1, range: 182, 295km day-1), despite greater spring travel distances. Birds with longer non-breeding periods, however, migrated north faster. Climate-driven mismatches in migratory timing may be less of a concern for western than for eastern flycatcher populations, given recent con-generic analyses (C. sordidulus, C. virens). However, accelerated high-latitude changes, may nonetheless impact boreal breeders.

FEATURE SELECTION FOR PREDICTING LIVE MIGRATION CHARACTERISTICS OF VIRTUAL MACHINES

Virtual machine migration is widely used in cloud data centers to scale and maintain the stability of cloud services. However, the performance metrics of virtual machine (VM) applications during migration that are set in the Service Level Agreements may deteriorate. Before starting a migration, it is necessary to evaluate the migration characteristics that affect the quality of service. These characteristics are the total migration time and virtual machine downtime, which are random variables that depend on a variety of factors. The prediction is based on the VM monitoring data. In this paper, we select the most suitable factors for forecasting five types of migrations: precopy migration, postcopy migration, and modification of precopy migration such as CPU throttling, data compression, and delta compression of modified memory pages. To do this, we analyzed a dataset that includes data on five types of migrations, approximately 8000 records of each type. Using correlation analysis, the factors that mostly affect the total migration time and the VM downtime are chosen. These characteristics are predicted using machine learning methods such as linear regression and the support vector machine. It is shown that the number of factors can be reduced almost twice with the same quality of the forecast. In general, linear regression provides relatively high accuracy in predicting the total migration time and the duration of virtual machine downtime. At the same time, the observed nonlinearity in the correlations shows that it is advisable to use the support vector machine to improve the quality of the forecast.

Total Blood Exosomes in Breast Cancer: Potential Role in Crucial Steps of Tumorigenesis

Exosomes are crucial players in cell-to-cell communication and are involved in tumorigenesis. There are two fractions of blood circulating exosomes: free and cell-surface-associated. Here, we compared the effect of total blood exosomes (contain plasma exosomes and blood cell-surface-associated exosomes) and plasma exosomes from breast cancer patients (BCPs, n = 43) and healthy females (HFs, n = 35) on crucial steps of tumor progression. Exosomes were isolated by ultrafiltration, followed by ultracentrifugation, and characterized by cryo-electron microscopy (cryo-EM), nanoparticle tracking analysis, and flow cytometry. Cryo-EM revealed a wider spectrum of exosome morphology with lipid bilayers and vesicular internal structures in the HF total blood in comparison with plasma. No differences in the morphology of both exosomes fractions were detected in BCP blood. The plasma exosomes and total blood exosomes of BCPs had different expression levels of tumor-associated miR-92a and miR-25-3p, induced angiogenesis and epithelial-to-mesenchymal transition (EMT), and increased the number of migrating pseudo-normal breast cells and the total migration path length of cancer cells. The multidirectional effects of HF total blood exosomes on tumor dissemination were revealed; they suppress the angiogenesis and total migration path length of MCF10A, but stimulate EMT and increase the number of migrating MCF10A and the total path length of SKBR3 cells. In addition, HF plasma exosomes enhance the metastasis-promoting properties of SKBR3 cells and stimulate angiogenesis. Both cell-free and blood cell-surface-associated exosomes are involved in the crucial stages of carcinogenesis: the initiation of EMT and the stimulation of proliferation, cell migration, and angiogenesis. Thus, for the estimation of the diagnostic/prognostic significance of circulating exosomes in the blood of cancer patients more correctly, the total blood exosomes, which consist of plasma exosomes and blood cell-surface-associated exosomes should be used.

Analytical Approach to Estimating Total Migration Time of Virtual Machines With Various Applications

Cloud applications and services such as social networks, file sharing services, and file storage have become increasingly popular among users in recent years. This leads to the enlargement of data centers, and an increase in the number of servers and virtual machines. In such systems, live migration is used to move virtual machines from one server to another, which affects the quality of service. Therefore, the problem of finding the total migration time is relevant. This article proposes analytical approach to obtaining analytical expression of the probability density of the total migration time based on the use of the apparatus of characteristic functions. The obtained expression is used to calculate characteristics of migration, taking into account the applications contributing the most randomness to the total migration time. To simplify the calculation of migration characteristics, the use of the Laguerre series can be recommended as giving more reliable results compared to Gram-Charlier series.

A randomized double-blind noninferiority trial, evaluating migration of a cemented vitamin E-stabilized highly crosslinked component compared with a standard polyethylene component in reverse hybrid total hip arthroplasty

Aims Radiostereometric analysis (RSA) studies of vitamin E-doped, highly crosslinked polyethylene (VEPE) liners show low head penetration rates in cementless acetabular components. There is, however, currently no data on cemented VEPE acetabular components in total hip arthroplasty (THA). The aim of this study was to evaluate the safety of a new cemented VEPE component, compared with a conventional polyethylene (PE) component regarding migration, head penetration, and clinical results. Patients and Methods We enrolled 42 patients (21 male, 21 female) with osteoarthritis and a mean age of 67 years (sd 5), in a double-blinded, noninferiority, randomized controlled trial. The subjects were randomized in a 1:1 ratio to receive a reverse hybrid THA with a cemented component of either argon-gas gamma-sterilized PE component (controls) or VEPE, with identical geometry. The primary endpoint was proximal implant migration of the component at two years postoperatively measured with RSA. Secondary endpoints included total migration of the component, penetration of the femoral head into the component, and patient-reported outcome measurements. Results In total, 19 control implants and 18 implants in the VEPE group were analyzed for the primary endpoint. We found a continuous proximal migration of the component in the VEPE group that was significantly higher with a difference at two years of a mean 0.21 mm (95% confidence interval (CI) 0.05 to 0.37; p = 0.013). The total migration was also significantly higher in the VEPE group, but femoral head penetration was lower. We found no difference in clinical outcomes between the groups. Conclusion At two years, this cemented VEPE component, although having a low head penetration and excellent clinical results, failed to meet noninferiority compared with the conventional implant by a proximal migration above the proposed safety threshold of RSA. The early proximal migration pattern of the VEPE component is a reason for continued monitoring, although a specific threshold for proximal migration and risk for later failure cannot be defined and needs further study. Cite this article: Bone Joint J 2019;101-B:1192–1198

An overview of virtual machine live migration techniques

In a cloud computing the live migration of virtual machines shows a process of moving a running virtual machine from source physical machine to the destination, considering the CPU, memory, network, and storage states. Various performance metrics are tackled such as, downtime, total migration time, performance degradation, and amount of migrated data, which are affected when a virtual machine is migrated. This paper presents an overview and understanding of virtual machine live migration techniques, of the different works in literature that consider this issue, which might impact the work of professionals and researchers to further explore the challenges and provide optimal solutions.

Fully-covered esophageal stent migration rates in benign and malignant disease: a multicenter retrospective study

Background and study aims Stent migration is a common complication of fully-covered self-expanding metal stents (FCSEMS), but the rate of clinically relevant migration as defined by stent migration followed by reintervention via endoscopy for stent replacement is unknown. The goal of this study is to gain insight into the total migration rate and clinically relevant migration rate of different types of FCSEMS placed within benign and malignant strictures with specific attention paid to stent manufacturer, diameter, and length. Patients and methods Multicenter retrospective analysis of endoscopic data from patients with FCSEMS placed within benign or malignant strictures. FCSEMS used included a variety of sizes and manufacturers. Results A total of 369 patients were included, 161 of whom had benign strictures and 208 of whom had malignant strictures. The total migration rate and clinically relevant migration rate in benign strictures were 30 % and 17 %, respectively. For benign strictures, Wallflex stents had a clinically relevant migration rate of 15 %, compared to Endomaxx stents with 19 %, and Evolution stents with 25 % (P = 0.52). The total migration rate and clinically relevant migration rates in malignant strictures were 23 % and 14 %, respectively. Evolution stents had a significantly higher clinically relevant migration rate (29 %) than the Wallflex stents (7 %) and the endomaxx stents (12 %), P = 0.003. Conclusion This study is the largest to investigate migration rates for FCSEMS in benign and malignant strictures. Clinically relevant migration is a relatively common occurrence with all stent types studied and better anti-migration features are needed.