streptomyces chattanoogensis
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2019 ◽  
Vol 20 (12) ◽  
pp. 983-994
Author(s):  
Zi-yue Li ◽  
Qing-ting Bu ◽  
Jue Wang ◽  
Yu Liu ◽  
Xin-ai Chen ◽  
...  

ChemInform ◽  
2016 ◽  
Vol 47 (19) ◽  
Author(s):  
Yuan-Yang Guo ◽  
Han Li ◽  
Zhen-Xing Zhou ◽  
Xu-Ming Mao ◽  
Yi Tang ◽  
...  

2015 ◽  
Vol 17 (24) ◽  
pp. 6114-6117 ◽  
Author(s):  
Yuan-Yang Guo ◽  
Han Li ◽  
Zhen-Xing Zhou ◽  
Xu-Ming Mao ◽  
Yi Tang ◽  
...  

2015 ◽  
Vol 173 ◽  
pp. 25-33 ◽  
Author(s):  
Shui-Ping Liu ◽  
Peng-Hui Yuan ◽  
Yue-Yue Wang ◽  
Xiao-Fang Liu ◽  
Zhen-Xing Zhou ◽  
...  

2015 ◽  
Vol 99 (6) ◽  
pp. 2715-2726 ◽  
Author(s):  
Shui-Ping Liu ◽  
Pin Yu ◽  
Peng-Hui Yuan ◽  
Zhen-Xing Zhou ◽  
Qing-Ting Bu ◽  
...  

2014 ◽  
Vol 99 (3) ◽  
pp. 1287-1298 ◽  
Author(s):  
Zhen-Xing Zhou ◽  
Qing-Qing Xu ◽  
Qing-Ting Bu ◽  
Shui-Ping Liu ◽  
Pin Yu ◽  
...  

2014 ◽  
Vol 80 (22) ◽  
pp. 6879-6887 ◽  
Author(s):  
Pin Yu ◽  
Shui-Ping Liu ◽  
Qing-Ting Bu ◽  
Zhen-Xing Zhou ◽  
Zhen-Hong Zhu ◽  
...  

ABSTRACTDetailed mechanisms ofWhiB-like (Wbl) proteins involved in antibiotic biosynthesis and morphological differentiation are poorly understood. Here, we characterize the role of WblAch, aStreptomyces chattanoogensisL10 protein belonging to this superfamily. Based on DNA microarray data and verified by real-time quantitative PCR (qRT-PCR), the expression ofwblAchwas shown to be positively regulated by AdpAch. Gel retardation assays and DNase I footprinting experiments showed that AdpAchhas specific DNA-binding activity for the promoter region ofwblAch. Gene disruption and genetic complementation revealed that WblAchacts in a positive manner to regulate natamycin production. WhenwblAchwas overexpressed in the wild-type strain, the natamycin yield was increased by ∼30%. This provides a strategy to generate improved strains for natamycin production. Moreover, transcriptional analysis showed that the expression levels ofwhigenes (includingwhiA,whiB,whiH, andwhiI) were severely depressed in the ΔwblAchmutant, suggesting that WblAchplays a part in morphological differentiation by influencing the expression of thewhigenes.


FEBS Letters ◽  
2014 ◽  
Vol 588 (17) ◽  
pp. 3259-3264 ◽  
Author(s):  
Yue-Yue Wang ◽  
Xin-Xin Ran ◽  
Wei-Bin Chen ◽  
Shui-Ping Liu ◽  
Xiao-Sheng Zhang ◽  
...  

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