scholarly journals Bidirectional Regulation of AdpAch in Controlling the Expression of scnRI and scnRII in the Natamycin Biosynthesis of Streptomyces chattanoogensis L10

2018 ◽  
Vol 9 ◽  
Author(s):  
Pin Yu ◽  
Qing-Ting Bu ◽  
Yi-Li Tang ◽  
Xu-Ming Mao ◽  
Yong-Quan Li
Keyword(s):  
Bidirectional Regulation ◽  
Streptomyces Chattanoogensis

1997-P: Bidirectional Regulation of Energy Homeostasis Mediated by Estrogen Receptor a and ß in the Medial Amygdala

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1997-P
Author(s):  
HUI YE ◽  
YANLIN HE ◽  
LUCAS IBRAHIMI ◽  
SARAH SCHAUL ◽  
PEI LUO ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Energy Homeostasis ◽  
Medial Amygdala ◽  
Bidirectional Regulation

scholarly journals Activation of anthrachamycin biosynthesis in Streptomyces chattanoogensis L10 by site-directed mutagenesis of rpoB

2019 ◽  
Vol 20 (12) ◽  
pp. 983-994
Author(s):  
Zi-yue Li ◽  
Qing-ting Bu ◽  
Jue Wang ◽  
Yu Liu ◽  
Xin-ai Chen ◽  
...  
Keyword(s):  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Streptomyces Chattanoogensis

scholarly journals Hyperprogressive disease after radiotherapy combined with anti-PD-1 therapy in renal cell carcinoma: a case report and review of the literature

BMC Urology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Chao Liu ◽  
Jingjing Piao ◽  
Zhiyang Shang
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
General Condition ◽  
Renal Cell ◽  
Checkpoint Inhibitors ◽  
Lung Metastases ◽  
Left Lung ◽  
The Third ◽  
Bidirectional Regulation ◽  
Hyperprogressive Disease

Abstract Background Studies have shown that immune checkpoint inhibitors (ICIs) have limited efficacy and can even increase tumour burden in short time periods. This is usually called hyperprogressive disease (HPD). To date, there are few reports regarding HPD; fewer have analysed the relationship between HPD and radiotherapy combined with ICIs, and their conclusions are controversial. Case presentation A 42-year-old woman was diagnosed with stage IV renal clear cell carcinoma. The patient had previously received sorafenib and pazopanib as first- and second-line therapies, respectively. She received radiotherapy combined with nivolumab. Eighteen days after administration of the third dose of nivolumab, the patient’s general condition deteriorated; this was associated with immune-related adverse events. Computed tomography showed that the diameter of left lung metastases had sharply increased. A biopsy of the lung metastasis showed no infiltration of lymphocytes. The patient’s general condition worsened and she died of the disease on the 70th day after administration of the third dose of nivolumab. Conclusions This report describes the development of HPD following the administration of radiotherapy combined with ICIs in a case of advanced renal cell carcinoma. The case indicates that radiotherapy may show bidirectional regulation effects on anti-tumour immune response. If the immunosuppressive function of radiotherapy is dominant, combined with ICIs, it could result in HPD.

scholarly journals Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases.

1994 ◽  
Vol 269 (8) ◽  
pp. 6093-6100 ◽  
Author(s):  
R. Taussig ◽  
W.J. Tang ◽  
J.R. Hepler ◽  
A.G. Gilman
Keyword(s):  
Adenylyl Cyclases ◽  
Bidirectional Regulation

scholarly journals WblAch, a Pivotal Activator of Natamycin Biosynthesis and Morphological Differentiation in Streptomyces chattanoogensis L10, Is Positively Regulated by AdpAch

2014 ◽  
Vol 80 (22) ◽  
pp. 6879-6887 ◽  
Author(s):  
Pin Yu ◽  
Shui-Ping Liu ◽  
Qing-Ting Bu ◽  
Zhen-Xing Zhou ◽  
Zhen-Hong Zhu ◽  
...  
Keyword(s):  
Morphological Differentiation ◽  
Binding Activity ◽  
Transcriptional Analysis ◽  
Antibiotic Biosynthesis ◽  
Content Type ◽  
Real Time Quantitative Pcr ◽  
Dna Binding Activity ◽  
In The Wild ◽  
Natamycin Production ◽  
Streptomyces Chattanoogensis

ABSTRACTDetailed mechanisms ofWhiB-like (Wbl) proteins involved in antibiotic biosynthesis and morphological differentiation are poorly understood. Here, we characterize the role of WblAch, aStreptomyces chattanoogensisL10 protein belonging to this superfamily. Based on DNA microarray data and verified by real-time quantitative PCR (qRT-PCR), the expression ofwblAchwas shown to be positively regulated by AdpAch. Gel retardation assays and DNase I footprinting experiments showed that AdpAchhas specific DNA-binding activity for the promoter region ofwblAch. Gene disruption and genetic complementation revealed that WblAchacts in a positive manner to regulate natamycin production. WhenwblAchwas overexpressed in the wild-type strain, the natamycin yield was increased by ∼30%. This provides a strategy to generate improved strains for natamycin production. Moreover, transcriptional analysis showed that the expression levels ofwhigenes (includingwhiA,whiB,whiH, andwhiI) were severely depressed in the ΔwblAchmutant, suggesting that WblAchplays a part in morphological differentiation by influencing the expression of thewhigenes.

Bidirectional regulation of angiogenesis by phytoestrogens through estrogen receptor-mediated signaling networks

2016 ◽  
Vol 14 (4) ◽  
pp. 241-254 ◽  
Author(s):  
Hai-Xin LIU ◽  
Yu WANG ◽  
Qing LU ◽  
Ming-Zhu YANG ◽  
Guan-Wei FAN ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Signaling Networks ◽  
Bidirectional Regulation

scholarly journals Bidirectional Regulation of Hippocampal Long-Term Synaptic Plasticity and Its Influence on Opposing Forms of Memory

2010 ◽  
Vol 30 (10) ◽  
pp. 3813-3825 ◽  
Author(s):  
G. Malleret ◽  
J. M. Alarcon ◽  
G. Martel ◽  
S. Takizawa ◽  
S. Vronskaya ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Bidirectional Regulation

The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia

2021 ◽  
Vol 13 (590) ◽  
pp. eabd6434
Author(s):  
Patrick Sweeney ◽  
Michelle N. Bedenbaugh ◽  
Jose Maldonado ◽  
Pauline Pan ◽  
Katelyn Fowler ◽  
...  
Keyword(s):  
Sexual Dimorphism ◽  
Feeding Behavior ◽  
Critical Role ◽  
Brain Regions ◽  
Sexually Dimorphic ◽  
Male And Female ◽  
Female Mice ◽  
Bidirectional Regulation ◽  
Fear And Anxiety ◽  
Agouti Related Protein

Ablation of hypothalamic AgRP (Agouti-related protein) neurons is known to lead to fatal anorexia, whereas their activation stimulates voracious feeding and suppresses other motivational states including fear and anxiety. Despite the critical role of AgRP neurons in bidirectionally controlling feeding, there are currently no therapeutics available specifically targeting this circuitry. The melanocortin-3 receptor (MC3R) is expressed in multiple brain regions and exhibits sexual dimorphism of expression in some of those regions in both mice and humans. MC3R deletion produced multiple forms of sexually dimorphic anorexia that resembled aspects of human anorexia nervosa. However, there was no sexual dimorphism in the expression of MC3R in AgRP neurons, 97% of which expressed MC3R. Chemogenetic manipulation of arcuate MC3R neurons and pharmacologic manipulation of MC3R each exerted potent bidirectional regulation over feeding behavior in male and female mice, whereas global ablation of MC3R-expressing cells produced fatal anorexia. Pharmacological effects of MC3R compounds on feeding were dependent on intact AgRP circuitry in the mice. Thus, the dominant effect of MC3R appears to be the regulation of the AgRP circuitry in both male and female mice, with sexually dimorphic sites playing specialized and subordinate roles in feeding behavior. Therefore, MC3R is a potential therapeutic target for disorders characterized by anorexia, as well as a potential target for weight loss therapeutics.

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