Using hierarchical similarity to examine the genetics of Behçet’s disease

Objective Behçet’s disease (BD) is a multisystem inflammatory disease that affects patients along the historic silk road. Thus far, the pathogenesis of the disease has proved elusive due to the complex genetic interactions of the disease. In this paper, we seek to clarify the genetic factors of the disease while also uncovering other diseases of interest that present with a similar genotype as BD. Results To do this, we employ a convergent functional genomics approach by leveraging the hierarchical similarity tool available in Geneweaver. Through our analysis, we were able to ascertain 7 BD consensus genes and 16 autoimmune diseases with genetic overlap with BD. The results of our study will inform further research into the pathogenesis of Behçet’s disease.

Behcet's Disease Network Analysis: A Convergent Functional Genomics Approach

Behçet's disease (BD) is a multisystem inflammatory disease that effects patients along the historic silk road. Thus far, the patheogensis of the disease has proved elusive due to the complex genetic interactions and unknown environmental or viral triggering factors of the disease. In this paper, we seek to clarify the gentic factors of the disease while also uncovering other diseases of interest that present with a similar genotype as BD. To do this, we employ a computational functional genomics approach by leveraging the hierarchical similarity tool available in Geneweaver. Through our analysis, we were able to ascertain 7 BD consensus genes and 16 autoimmune diseases with genetic overlap with BD. The results of our study will inform further research into the patheogenesis of Behçet's Disease.

Economic Opportunities in One Belt One Road (OBOR) Project and Turkey's Position

After a short time from the discovery of silk by China, it had become a status symbol in the world, and it reached up to the Roman Empire. This created trade routes and they were called the “Silk Road.” The goods that came to the Mediterranean through this historical trade route were distributed to the world through Mediterranean ports. However, invention of compass by China paved the way for geographical discoveries and new trade routes were found as a result of these discoveries. These developments reduced importance of the Silk Road. Approx. 500 years later, China became a manufacturing center as a result of its trade with the West. This situation reminded China of the “Historic Silk Road,” and they announced the project under the name of One Belt One Road to the world in 2013, which is essentially a modern version of the “Historic Silk Road.” Economic Opportunities In Obor Project will be analysed in this study.

Degradation profiles of silk textiles in diverse environments: Synchrotron based infrared micro-spectroscopy analysis

In this paper, synchrotron based infrared micro-spectroscopy was utilized to describe the degradation profile of fibroin contained in silk textiles (Bombyx mori). The spatial distributions of deterioration effects in silk samples artificially aged at an assortment of conditions (thermal, hydrolytic and ultraviolet) were distinctly visualised and in accordance with the findings from conventional infrared spectroscopy in references. Further this method was applied on a historic sample from a private collection in Melbourne, and presented consistent results. This established synchrotron IR chemical mapping method could enable museum professionals to better understand the preservation state of historic silk and make informed decisions for conservation.