A COMPARATIVE STUDY ON GREEVA BASTI AND ITS MODIFIED SCHEDULE IN GREEVA HUNDANAM WITH TILA TAILA

Greeva Hundanam is a condition in which vitiated Vata lodges in the neck region and leads to stiffness of the neck with signs and symptoms of vitiation of Vata. The word Greeva means neck. The word Hun-danam conveys two meanings. The first one is “Shiro Prabhrutinam Antah Pravesha”. It means inward intrusion of the head and its allied parts. It is possible due to implication with cervical parts. Structural de-formity is also a suggestive condition. The other meaning is “Greeva Stambha”, which denotes the re-striction of the movements of the neck. Cervical Spondylosis is the degenerative condition of the cervical spine with signs and symptoms like neck pain, numbness, muscle spasm, neck stiffness, restricted range of movements of neck etc. Signs and symptoms of Greeva Hundanam resembles with that of Cervical Spon-dylosis. So, both Clinical Conditions can be compared with each other. Tila Taila is having Vatahara prop-erty used in treating Vatavyadhi. Also, in the previous study it has been reported that Tila Taila used in Greeva Basti was beneficial in reducing the signs and symptoms of Greeva Hundanam. So, in this study an attempt was done to evaluate and compare the effect of Greeva Basti and its modified schedule in Greeva Hundanam with Tila Taila.

Using Computer Simulations to Plan Construction Projects Accurately

The three main objectives in construction projects are completing the project on time, within budget, and with good quality. Each construction project is unique and unpredictable making it beneficial to model the project before executing it. There are many ways to model a construction project; however, computer models are ideal. It is very costly and time consuming to experiment with the actual system. Therefore, by using a computer simulation, accurate data can be collected from the project without the time and cost drawbacks. The specific construction project researched is based on a real project from Fort Mcmurray Alberta, Canada. The construction project involved the delivery and erection of three different types of steel in a construction site. Once the steel has been delivered, it needs to be stored and then carried by forklift to one of two cranes to be erected. A schedule was provided for which days each type of material was expected to be delivered and erected, however this schedule did not account for the 20% chance that any delivery could be delayed by one day or the 10% chance that deliveries could be delayed by two days. A model project was created on Simphony.NET with the assumptions that work could commence the entire day (24 hours), the site has unlimited storage, and a delay in one delivery does not delay all the deliveries after it. The schedule for the project was then modified to reflect the results of the simulation. The modified schedule showed that several deliveries of materials were delayed. However, due to the model’s assumptions and the time for erection being relatively short, the planned schedule for the erection of the materials was not delayed. By using the data collected from the computer simulation it was possible to more accurately plan the schedule for this construction project.

A new modified sunitinib schedule for metastatic renal cell cancer (mRCC): A pilot study.

471 Background: Oral sunitinib administration at 50 mg daily given for 4 weeks followed by 2 weeks off treatment (4+2 schedule) is a standard first line for mRCC treatment. About 20% of patients had to discontinue treatment permanently and 50% of patients are forced to reduce the doses due to adverse events [Motzer RJ, J Clin Oncol. 2009]. A meta-analysis showed that increase exposure to sunitinib is associated with improved clinical outcome [Houk BE, Cancer Chemother Pharmacol. 2010]. Methods: This is a pilot study in which consecutive mRCC patients admitted to our hospital who had at least a grade 2 toxicity with sunitinib, were switched to a modified schedule maintaining the same dose-intensity of 4+2 schedule: starting on Monday, 1 tablet (50 mg) a day for 5 consecutive days a week for 5 weeks and 1 tablet per day on days 1, 3 and 5 in the sixth week (28 tablets in 6 weeks), until disease progression. Primary end points were toxicity changes assessment and schedule feasibility, secondary end point was overall progression free survival (PFS). Results: Eight nephrectomized patient were enrolled: 6 males; median age 61; 37% good, 50% intermediate and 13% poor MSKCC risk; 3 patient pretreated; 6 clear cell histologies, 1 papillary and 1 undifferentiated histotypes. Median time from start therapy to switch was 7.4 months (range 1.4-16.1). Treatment delays and dose reductions were reduced from 50% to 25% and from 37% to 12% of patients respectively. The table shows the toxicity changes: there were no new toxicities. PFS was 16.3 months (CI 95% 5.6-23.4). Conclusions: This new modified schedule requires and deserves further studies. [Table: see text]