oral immunogenicity
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2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Elena A. Uvarova ◽  
Pavel A. Belavin ◽  
Natalya V. Permyakova ◽  
Alla A. Zagorskaya ◽  
Olesya V. Nosareva ◽  
...  

Two lines of transgenic carrot plants producingMycobacterium tuberculosisproteins (ESAT6 and CFP10) have been constructed. The target proteins are present in carrot storage roots at a level not less than 0.056% of the total storage protein (TSP) for ESAT6 and 0.002% of TSP for CFP10. As has been shown, oral immunization of mice induces both the cell-mediated and humoral immunities. These data suggest that the proteins in question are appropriate as a candidate edible vaccine against tuberculosis.


PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e52907 ◽  
Author(s):  
Assunta Pelosi ◽  
David Piedrafita ◽  
Giorgio De Guzman ◽  
Robert Shepherd ◽  
John D. Hamill ◽  
...  

2012 ◽  
Vol 11 (3) ◽  
pp. 315-324 ◽  
Author(s):  
Hui-Ting Chan ◽  
Min-Yuan Chia ◽  
Victor Fei Pang ◽  
Chian-Ren Jeng ◽  
Yi-Yin Do ◽  
...  

2012 ◽  
Vol 44 (10) ◽  
pp. 823-830 ◽  
Author(s):  
Y. Zhang ◽  
S. Chen ◽  
J. Li ◽  
Y. Liu ◽  
Y. Hu ◽  
...  

2010 ◽  
Vol 30 (3) ◽  
pp. 417-424 ◽  
Author(s):  
Ruth E. Soria-Guerra ◽  
Sergio Rosales-Mendoza ◽  
Leticia Moreno-Fierros ◽  
Rubén López-Revilla ◽  
Ángel G. Alpuche-Solís

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