membrane deterioration
Recently Published Documents


TOTAL DOCUMENTS

23
(FIVE YEARS 1)

H-INDEX

12
(FIVE YEARS 0)

Agronomy ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1044
Author(s):  
Ikuo Takahashi ◽  
Kai Jiang ◽  
Tadao Asami

Plant hormones strigolactones (SLs) were recently reported to induce leaf senescence. It was reported that sugar suppresses SL-induced leaf senescence in the dark; however, the mechanism of the crosstalk between SLs and the sugar signal in leaf senescence remains elusive. To understand this mechanism, we studied the effects of glucose (Glc) on various senescence-related parameters in leaves of the rice. We found that sugars alleviated SL-induced leaf senescence under dark conditions, and the co-treatment with Glc suppressed SL-induced hydrogen peroxide generation and membrane deterioration. It also suppressed the expression levels of antioxidant enzyme genes upregulated by SL, suggesting that Glc alleviates SL-induced senescence by inhibiting the oxidative processes. SLs can adapt to nutrient deficiency, a major factor of leaf senescence; therefore, we suggest the possibility that Glc and SL monitor the nutrient status in plants to regulate leaf senescence.


2019 ◽  
Vol 39 (5) ◽  
pp. 479-485
Author(s):  
Michael Boehm ◽  
Julia Niewczas ◽  
Harald Herkner ◽  
Franz Koenig ◽  
Klaus Kratochwill ◽  
...  

Background Peritoneal dialysis (PD) is complicated by a high rate of adverse events that might be attributed to cytotoxicity of currently used PD fluids. However, clinical development of novel PD fluids is virtually non-existent, in part due to difficulties in recruiting sufficiently large populations for adequately powered trials. The aim of this study is to understand the potential impact of introducing composite outcomes on clinical trial feasibility in PD. Methods A composite outcome “major adverse peritoneal events (MAPE)” was designed to combine clinically relevant complications of PD, such as ( 1 ) technical failure (cause-specific for peritonitis and/or insufficient dialysis), ( 2 ) peritonitis, and ( 3 ) peritoneal membrane deterioration. Incidence rates of individual endpoints were obtained from the literature and expert panel estimations, and population sizes were computed based on Chi-square test for adequately powered confirmatory randomized controlled clinical trials with 2 parallel arms. Results Incidence rates for technical failure, peritonitis, and peritoneal membrane deterioration were estimated at 15%, 50%, and 23%, respectively, at 2 years follow-up, with adequate agreement between the literature and expert opinion. Assuming that a given intervention reduces adverse outcomes by 30%, an adequately powered clinical trial needs to recruit up to 1,720 patients when studying individual outcomes. Combining endpoints increases power in simulated trials despite considerable overlap, and the composite outcome MAPE reduces the required population to 202 patients aiming for 80% power. Conclusion Introduction of the composite outcome MAPE, covering relevant major adverse peritoneal events, may improve the feasibility of clinical trials to adequately test novel PD fluids.


2019 ◽  
Vol 7 (14) ◽  
pp. 8167-8176 ◽  
Author(s):  
Jia Le Li ◽  
Yu Zhang ◽  
Sui Zhang ◽  
Minqiu Liu ◽  
Xue Li ◽  
...  

Membrane fouling and membrane deterioration are two major concerns since they greatly worsen membrane performance in pressure retarded osmosis (PRO) and shorten the membrane lifetime.


2015 ◽  
Vol 36 (7) ◽  
pp. 1068-1076 ◽  
Author(s):  
Afşin Y. Çetinkaya ◽  
Emre Oğuz Köroğlu ◽  
Neslihan Manav Demir ◽  
Derya Yılmaz Baysoy ◽  
Bestamin Özkaya ◽  
...  

2012 ◽  
Vol 148 ◽  
pp. 97-103 ◽  
Author(s):  
Jian Sun ◽  
Changbao Li ◽  
K. Nagendra Prasad ◽  
Xiangrong You ◽  
Li Li ◽  
...  

2011 ◽  
Vol 49 (10) ◽  
pp. 1220-1227 ◽  
Author(s):  
Nadia Rolny ◽  
Lorenza Costa ◽  
Cristian Carrión ◽  
Juan José Guiamet

Sign in / Sign up

Export Citation Format

Share Document