A New Tool to Assess Quality of Life in Patients with Idiopathic Pulmonary Fibrosis or Non-specific Interstitial Pneumonia

Background Quality of life (QoL) is significantly impaired in patients with pulmonary fibrosis, however reliable tools to assess QoL issues specific for this group of patients are still missing. We thus aimed to develop a new questionnaire called “Quality of life in patients with idiopathic pulmonary fibrosis” (QPF) to measure QoL in patients with fibrotic idiopathic interstitial pneumonias (IIP). Methods An item pool was created on the basis of a German expert group with support of patients suffering from pulmonary fibrosis. In a 1st step, this version of the questionnaire was completed by 52 patients with idiopathic pulmonary fibrosis (IPF) or non-specific interstitial pneumonia (NSIP). Following this, an item- and an exploratory factor analysis was carried out and a 2nd version created. In a multicenter validation study in a one-group pre-post design, the questionnaire was filled in by 200 patients with IIP (IPF = 190, iNSIP = 10) at 2 time points with an interval of 6 months. Cross-validation was carried out with the St. Georges Respiratory Questionnaire (SGRQ). Results The mean age of the patients was 71.0 years (50–90 years), 82.5 % were male. Item analysis revealed that most of Cronbach alpha and selectivity values of QPF-scales could be considered as sufficient (e. g. QPF-scale “condition” [alpha = 0.827], “impairment” [alpha = 0.882]). At scale level, there were significant differences in terms of a deterioration or improvement in the QPF-condition and QPF-breathlessness scales and also in the SGRQ-activity scale. Analysis of construct validation of QPF and SGRQ showed moderate correlations between both questionnaires. A deterioration in health status from the patient’s and doctorʼs perspective was seen in the scales “impairment”, “shortness of breath” and “health status” of the QPF. The QPF was able to detect a change in the patientʼs mood (“condition” scale) in the course of treatment. Conclusion This newly developed questionnaire maps the special needs of the patients well. The QPF is suitable for screening of quality of life as well as for supplementing the medical history and for monitoring the course of disease in fibrotic IIPs.

The Effect of Mood on Predictive Sentence Processing by Older Adults

This study examined the effect of mood on predictive sentence processing by older adults. A self-paced reading task was implemented among a group of younger adults and older adults to measure their performance in online sentence processing. Half of the sentences were highly predictable, whereas the other half were lowly predictable. Music was used to induce positive or negative mood. Results show that in the positive mood condition, highly predictable sentences were processed more efficiently than lowly predictable sentences in both older and younger adults, but no significant age difference was found in the effect of predictability. In the negative mood condition, younger adults processed highly predictable sentences more efficiently than lowly predictable sentences, but there was no significant difference in reading times between the different types of sentences in older adults. The findings suggest that predictive sentence processing might be inhibited by negative mood in older adults. Practical implications of the findings are discussed.

A New Tool to Assess Quality of life in Patients with Idiopathic Pulmonary Fibrosis or Non-Specific Interstitial Pneumonia *

Background: Quality of life (QoL) is significantly impaired in patients with pulmonary fibrosis, however reliable tools to assess QoL are still missing. We thus aimed to develop a new questionnaire called QPF to measure QoL in patients with fibrotic idiopathic interstitial pneumonias (IIP). Methods: As part of a multi-center validation study in a pre-post design, 200 patients with idiopathic pulmonary fibrosis (IPF) or idiopathic non-specific interstitial pneumonia (iNSIP) filled in the questionnaire at 2 measurement time points with an interval of 6 months. Cross-validation was carried out with the St. Georges Respiratory Questionnaire (SGRQ). Results: The alpha of the QPF-total score and its subscales range from .858 to .616 and can be rated as good. In contrast to the SGRQ, the QPF was able to detect a change in the patient's mood ("Condition" scale) in the course of treatment. This could be due to the SGRQ being a condition specific measure but also due to the greater amount of items, especially those with a job-related theme, which are not relevant for the sample examined. The questionnaire can be used to evaluate treatment response more appropriately, by collecting data on physical performance and general behaviour. Conclusion: This newly developed questionnaire maps the special needs of the patients well and is superior to the SGRQ. The QPF is suitable for screening as well as for supplementing the medical history and for monitoring the course of disease in fibrotic IIPs.

Profil Mood Atlet Pra-Pon Sepak Takraw Puteri Sulawesi Tengah Dalam Melakukan Latihan

The research was conducted to find out how much the mood of female pre-PON sepak takraw athletes in Sulawesi Tengah after doing the exercises and how the mood condition of the female pre-PON athletes after conducting the training. The method in this research is a survey research. The population of this study is 10 people, namely the pre-PON Sepak Takraw athletes of the women of Sulawesi Tengah with the sampling technique using total sampling. The collecting technique of data is a questionnaire using the rating scale. The results showed that fatigue indicators were 10% very low category, angry mood indicators were 24% very low category, ready feeling indicators were 54% good categories, tension indicators were 23.14% very low categories, self-assessment indicators were 40.85% low category, confused mood indicators were for 26.28% low category, and depression indicators were 6.85% very low category. Meanwhile, mood of the female athletes of sepak takraw is in a ready condition, this is based on the results of the ready feeling amount 54% with the high category. The conclusion is that the indicators of fatigue, anger, tension, self-assessment, confusion, depression are all in the very low categories, mean that even though the sepak takraw athletes do exercise every day and do not conduct match trials, they can still handle the psychological condition well. Meanwhile, the feeling ready indicators of the sepak takraw athletes have a high category.

A Positive Mood Induction for Reducing the Formation of Nocebo Effects from Side Effect Information

Background Providing treatment side effect information can increase the occurrence of side effects through nocebo effects. Nocebo effects from side effect information raise a dilemma for health care, as there is an ethical obligation to disclose potential unpleasant treatment information to patients. Purpose To test the hypothesis that a positive mood induction can block the development of nocebo effects that result from treatment side effect information. Methods In a laboratory setting, healthy participants were assigned to one of four conditions in a between-subjects randomized factorial trial. First, participants took part in a mood induction procedure, with half receiving a positive mood induction and the other half a neutral mood induction. Next, participants were told they would experience transcranial direct current stimulation (tDCS). Prior to a sham tDCS task, half of the participants were informed that headache pain is a side effect of tDCS, whereas the other half were not given this information. Results In the neutral mood condition, the provision of headache side effect information lead to a greater occurrence of headaches, more frequent headaches, and a higher maximum level of headache pain as compared to those given no side effect information. In the positive mood condition, a similar increase in headache pain did not manifest from the provision of side effect information. Conclusions This is the first experiment to find that a positive mood induction can block the formation of nocebo effects that arise from side effect information. Inducing positive moods may be an effective strategy for reducing nocebo effects in a variety of clinical settings.

White matter volume is decreased in bipolar disorder at early and late stages

Introduction: Bipolar disorder (BD) is a debilitating mood condition that affects approximately 1.3% of people worldwide, although some studies report up to 3.9% lifetime prevalence and 4-6% in adults when broad diagnostic criteria are applied. Objective: To compare differences in total white matter (WM), corpus callosum (CC) and total gray matter (GM) volumes in patients with type I BD at early and late stages compared with controls. Methods: Fifty-five subjects were enrolled in this study protocol. The double case-control design included 14 patients with BD at early stage; 15 patients at late stage; and their respective matched controls (14 and 12 subjects). Results: CC and total WM volumes were significantly smaller in patients with BD at early and late stages vs. controls. There was no difference for total GM volume in the early stage group, but in patients at late stage total GM volume was significantly smaller than in controls. The total GM volume reduction in patients at late stage is in agreement with the neuroprogression theory of BD. The reduction of WM volumes in total WM and in the CC at early and late stages supports the possibility that an early demyelination process could occur underlying the clinical manifestation of BD. Conclusion: Our findings may direct to the investigation of WM abnormalities in populations at high risk to develop BD, perhaps as early biomarkers before the overt syndrome.

Pemberian minuman kombinasi maltodekstrin dan vitamin C terhadap mood negatif dan VO2 maks atlet sepak bola

Background: Stress during the match can influence the change of mood and performance of athletes. Physical exercise can improve the ability of physiologically and psychologically, but lead to fatigue, dehydration and hypoglycemia. Maltodextrin has a lower osmolarity to improve emotional and performance. Vitamin C as a cofactor of neurotransmitters can support the performance of athletes.Objective: This study aimed to determine the effectiveness of a combination drinks of maltodextrin and vitamin C on mood and the correlation with VO2 max of football athletes.Method: This research is a quasi experimental with same subject design. The subjects were 14 University state of Yogyakarta football athlete. Subjects received a drink of 15% maltodextrin and 250 mg of vitamin C in 300 ml given 30 minutes before and 5 minutes after the performance test using yo-yo intermittent test continued by physical exercise. Measurement of mood would be done in 3 times; before cardiorespiratory test, 5 minutes after physical exercise, and 15 minutes after drink.Results: There are significant changes after consuming a combination of maltodextrin and vitamin C on the confusion (p<0.05), while components of anger, fatigue, depression, tension and vigor (p>0.05). There are significant changes after consuming plain water on fatigue and tension (p<0.05), while anger, confusion, depression, and vigor (p>0.05). There are no significant differences in every components of mood between two treatments. There is a correlation between anger and confusion with cardiorespiratory after consuming a combination of maltodextrin and vitamin C.Conclusion: Maltodextrin and vitamin C has the potential effect to improve the mood condition and have a correlation with VO2 Max improvement in football athletes.

The Relationship of Language and Emotion: N400 Support for an Embodied View of Language Comprehension

According to embodied theories, the symbols used by language are meaningful because they are grounded in perception, action, and emotion. In contrast, according to abstract symbol theories, meaning arises from the syntactic combination of abstract, amodal symbols. If language is grounded in internal bodily states, then one would predict that emotion affects language. Consistent with this, advocates of embodied theories propose a strong link between emotion and language [Havas, D., Glenberg, A. M., & Rinck, M. Emotion simulation during language comprehension. Psychonomic Bulletin & Review, 14, 436–441, 2007; Niedenthal, P. M. Embodying emotion. Science, 316, 1002–1005, 2007]. The goal of this study was to test abstract symbol vs. embodied views of language by investigating whether mood affects semantic processing. To this aim, we induced different emotional states (happy vs. sad) by presenting film clips that displayed fragments from a happy movie or a sad movie. The clips were presented before and during blocks of sentences in which the cloze probability of mid-sentence critical words varied (high vs. low). Participants read sentences while ERPs were recorded. The mood induction procedure was successful: Participants watching the happy film clips scored higher on a mood scale than those watching the sad clips. For N400, mood by cloze probability interactions were obtained. The N400 cloze effect was strongly reduced in the sad mood compared with the happy mood condition. Furthermore, a difference in late positivity was only present for the sad mood condition. The mood by semantic processing interaction observed for N400 supports embodied theories of meaning and challenges abstract symbol theories that assume that processing of word meaning reflects a modular process.