keto derivative
Recently Published Documents


TOTAL DOCUMENTS

32
(FIVE YEARS 0)

H-INDEX

10
(FIVE YEARS 0)

Plasma ◽  
2020 ◽  
Vol 3 (4) ◽  
pp. 187-195
Author(s):  
Ketao Chen ◽  
Meijuan Cao ◽  
Eileen Feng ◽  
Karl Sohlberg ◽  
Hai-Feng Ji

We present a method to prepare polyaminophenol from solid-state aminophenol monomers using atmospheric dielectric barrier discharge (DBD) plasma. The polymerizations of o-aminophenol and m-aminophenol are studied. The polymers were analyzed via Fourier-Transform inferred spectroscopy (FTIR) and ultraviolet-visible (UV-vis) spectroscopy. The kinetics of the polymerization reactions were investigated by using UV-vis and the polymerization was found to be first-order for both o-aminophenol and m-aminophenol. The resulting polymer film exhibits a conductivity of 1.0 × 10−5 S/m for poly-o-aminophenol (PoAP) and 2.3 × 10−5 S/m for poly-m-aminophenol (PmAP), which are two orders more conductive than undoped (~10−7 S/m) polyaniline (PANI), The PoAP has a quinoid structure and the PmAP has an open ring keto-derivative structure. The process provides a simple method of preparing conductive polyaminophenol films.


2020 ◽  
Vol 10 (4) ◽  
pp. 5869-5874 ◽  

Some compounds have been developed for the treatment of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) using different protocols; however, some methods use different reagents which are dangerous and require special conditions. the objective of this investigation was to synthesize some imidazole derivatives from 2-methyl-5-nitroimidazole using some reactions such as etherification, reduction, and a hydroxy-keto derivative formation. In addition, the theoretical activity of imidazole derivatives (compounds 2, 3 and 5-8) was evaluated in a docking model using hydroxylchloroquine and favipiravir as controls. The results showed that 1) compounds 3 and 5 have a higher affinity by 5ewp protein surface compared with hydroxylchloroquine, favipiravir, 2 and 6-8. In conclusion, compounds 3 and 5 could inhibit the biological activity of coronavirus.


2015 ◽  
Vol 57 (2) ◽  
pp. 159-166 ◽  
Author(s):  
Ajaya Kumar Behera ◽  
Basudam Adhikari ◽  
Pradip Kar
Keyword(s):  

2015 ◽  
Vol 61 (6) ◽  
pp. 724-730
Author(s):  
N.D. Eschenko ◽  
F.E. Putilina ◽  
O.V. Galkina ◽  
V.A. Vilkova ◽  
L.I. Zacharova ◽  
...  

The aim of this work was to study the ability of some estrogen 8a-analogues, that have CH 3 -group in the C-3 position, exhibit osteoprotective and cholesterolemic effects. The properties of these analogues was comparisoned with effects of native estradiol and 17a-ethynylestradiol (EE). We showed that compounds 3 ((d,l)-17b-acethoxy-3-methoxy-8a-estra-1,3,5(10)-triene) and 4 ((d,l)-3-methoxy-8a-estra-1,3,5(10)-triene-17-one) had the same osteoprotective and cholesterolemic effects as EE. The utherotropic effects of compound 3 and EE were the same, while the utherotropic activity of 17-keto derivative (compound 4) was higher than effect of EE. The osteoprotective and cholesterolemic effects of compounds 5 and 6 (d- or l-17b-acethoxy-3-methoxy- 13-ethyl-8a-gone-1,3,5(10)-triene) were approximately the same, however the utherotropic action of these compounds was different: the compound 5 had significantly lower activity, but the compound 6 had the same effect in comparison with EE. Thus, all studied estrogen 8a-analogues may be used as basic constructions for structural modifications which is necessary as medications with while spectrum of biological properties.


ChemInform ◽  
2010 ◽  
Vol 24 (49) ◽  
pp. no-no
Author(s):  
R. PULITI ◽  
A. FONTANA ◽  
G. CIMINO ◽  
C. A. MATTIA ◽  
L. MAZZARELLA

ChemInform ◽  
2009 ◽  
Vol 40 (10) ◽  
Author(s):  
Naveen K. Khare ◽  
Desh Deepak ◽  
Anakshi Khare

2006 ◽  
Vol 291 (6) ◽  
pp. E1160-E1167 ◽  
Author(s):  
Marcel D. Payet ◽  
Theodore L. Goodfriend ◽  
Lyne Bilodeau ◽  
Cherilu Mackendale ◽  
Lucie Chouinard ◽  
...  

EKODE, an epoxy-keto derivative of linoleic acid, was previously shown to stimulate aldosterone secretion in rat adrenal glomerulosa cells ( 15 ). In the present study, we investigated the effect of exogenous EKODE on cytosolic [Ca2+] increase and aimed to elucidate the mechanism involved in this process. Through the use of the fluorescent Ca2+-sensitive dye Fluo-4, EKODE was shown to rapidly increase intracellular [Ca2+] ([Ca2+]i) along a bell-shaped dose-response relationship with a maximum peak at 5 μM. Experiments performed in the presence or absence of Ca2+ revealed that this increase in [Ca2+]i originated exclusively from intracellular pools. EKODE-induced [Ca2+]i increase was blunted by prior application of angiotensin II, Xestospongin C, and cyclopiazonic acid, indicating that inositol trisphosphate (InsP3)-sensitive Ca2+ stores can be mobilized by EKODE despite the absence of InsP3 production. Accordingly, EKODE response was not sensitive to the phospholipase C inhibitor U-73122. EKODE mobilized a Ca2+ store included in the thapsigargin (TG)-sensitive stores, although the interaction between EKODE and TG appears complex, since EKODE added at the plateau response of TG induced a rapid drop in [Ca2+]i. 9-Oxo-octadecadienoic acid, another oxidized derivative of linoleic acid, also increases [Ca2+]i, with a dose-response curve similar to EKODE. However, arachidonic and linoleic acids at 10 μM failed to increase [Ca2+]i but did reduce the amplitude of the response to EKODE. It is concluded that EKODE mobilizes Ca2+ from an InsP3-sensitive store and that this [Ca2+]i increase is responsible for aldosterone secretion by glomerulosa cells. Similar bell-shaped dose-response curves for aldosterone and [Ca2+]i increases reinforce this hypothesis.


Hypertension ◽  
2004 ◽  
Vol 43 (2) ◽  
pp. 358-363 ◽  
Author(s):  
Theodore L. Goodfriend ◽  
Dennis L. Ball ◽  
Brent M. Egan ◽  
William B. Campbell ◽  
Kasem Nithipatikom

2003 ◽  
Vol 42 (10) ◽  
pp. 1838-1844 ◽  
Author(s):  
Luciano Cominacini ◽  
Anna Fratta Pasini ◽  
Ulisse Garbin ◽  
Cristina Nava ◽  
Anna Davoli ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document