The Effect of Snakehead Fish (Channa striata) Extract Capsule to the Albumin Serum Level of Post-operative Neurosurgery Patients

To evaluate the Effect of Snakehead Fish (Channa striata) Extract Capsule to the Albumin Serum Level of Post-operative Neurosurgery Patients. This research is a clinical research with Quasi-Experimental method . The experimental design used was one group pre-post test. The research design of one group pretest-posttest was measured using a pre-test which carried out before being given treatment and post-test carried out after being treated. The population of this study was all post-neurosurgical patients that treated at the West Nusa Tenggara General Hospital. Each patient who underwent surgery and included within research criteria was given Snakehead Fish (Channa striata) up to 3 weeks after surgery and the wound has healed. The sample consisted of 37 patients with criteria of over 18 years of age and no kidney disorders (proteinuria). The results of the data distribution of 37 patients stated that there were 12 males (32.4%) and 25 females (67.6%). The most number of diagnosis were abnormalities of meningioma and skull defect (17; 46% and 13; 35,1%). Mostly patients spent 8 – 14 days to control post-operatively (22; 59,4%). It was found that the pre-operative and post-operative albumin serum level had no significant difference (the significance value 0.115). The pre-operative and post-treatment albumin levels had a significant difference (a significance value of 0.003). However, albumin levels in post-operative and post-treatment had significant differences (significance value (0.001). This research is important for several reasons, including therapy in patients with pre-operative or recovery period after surgery. Snakehead fish can increase serum albumin levels in patients after surgery. The experimental design used was one group pre-post test. The research design of one group pretest-posttest was measured using a pre-test which was carried out before being given treatment and post-tests carried out after being treated. The treatment plan could be concisely reported.

ASSESSMENT OF ISCHEMIA MODIFIED ALBUMIN SERUM LEVEL IN ISO- PROTERENOL-INDUCED MYOCARDIAL INFARCTION

ASSESSMENT OF ISCHEMIA MODIFIED ALBUMIN SERUM LEVEL IN ISO- PROTERENOL-INDUCED MYOCARDIAL INFARCTION

Predictive factors for chemotherapy feasibility in elderly patients with solid tumor: Results of GERCOR old prospective multicenter study.

9511 Background: One quarter of patients with cancer are 75 year old and over. Previous studies suggested that geriatric parameters improved survival in elderly patients with solid advanced cancer and chemotherapy severe toxicity. A simplified scale would be helpful for oncologist to predict chemotherapy feasibility. The aim was to identify geriatric predictors of chemotherapy feasibility in chemo-naïve elderly patients. Methods: We conducted a prospective multicenter cohort study (NCT00664911). Inclusion criteria were: ≥ 75 years, solid tumor, able to receive at least 2/3 of the standard dose at the first course of treatment. Ten geriatric parameters were recorded at baseline by the oncologist: 1-three words test, 2-date and address for cognitive function, 3-Instrumental Activities of Daily Living (IADL), 4- monopodal stand-up test, 5-hospitalization during the previous year, 6-number of medicines taken for comorbidities, 7-creatinine clearance, 8-albumin serum level, 9-self-rated depressive mood question and 10-presence of a caregiver. The main outcome was chemotherapy feasibility defined by the ability to receive at least 3 months of the planned therapy. Multivariate logistic regression was used. Results: 576 patients were included in 49 centers from 2008 to 2012, 516 (89.6%) were eligible for analysis. Mean age was 81 years, 50.6% had colorectal cancer, 69.5% advanced stage and 83.6% had performance status 0-1. Chemotherapy feasibility was observed in 298 (57.8%) patients. Grade 3-4 toxicity was observed in 26.2% of patients. In multivariate analysis albuminemia < 30g/l (adjusted OR =2.34 CI95% [1.43-3.83]) and depressive mood (adjusted OR=1.55 CI95% [1.02-2.35]) were significantly associated with chemotherapy unfeasibility whereas others geriatrics parameters were not. Conclusions: Albuminemia and self rated depressive mood status were independently predictive for chemotherapy feasibility in elderly patients with solid tumor. Unexpectedly others geriatrics parameters were not independent predictors. Clinical trial information: NCT00664911.

Pemberian diet ekstra formula komersial dan diet ekstra filtrat ikan gabus intradialisis serta pengaruhnya terhadap kadar serum albumin dan kreatinin pasien dengan hemodialisis di RSU Dr. Saiful Anwar Malang

Background: Nowadays chronic kidney disease (CKD) is a serious health problem because of its increasing incidence. In Indonesia, approximately there are 100 CKD patients per 1 million people per year. Hemodialysis is one of ways to prolong CKD patient’s life that should be done recurrently and for a long time. However, hemodialysis causes loss of nutrients leading to high prevalence of malnutrition among CKD patients. Until today intradialysis diet therapy which can replace loss of nutrients particularly protein has not been initiated as part of diet therapy in Indonesian hospitals. To improve nutritional status and minimize mortality rate, oral intradialysis diet therapy with proper formula is needed.Objective: To study the effect of the supply of commercial formula and local catfish filtrate extra diet to albumin and creatinine serum level among hemodialysis patients.Method: The study was experimental with randomized control trial design carried out at Dialysis Installation of Dr. Saiful Anwar Hospital, Malang. There were as many as 36 hemodialysis patients divided into 3 groups; 1 group with standard diet, 1 group with commercial formula and standard diet, and 1 group with local catfish filtrate and standard diet. Data were obtained through interview, note taking, and laboratory tests which consisted of subject characteristics in weight, height, albumin and creatinin serum level as well as food intake one day before, during and one day after hemodialysis. Data analysis was done descriptively and inferentially using chi square, anova, and paired t-test. The conclusion was based on significance level (α ) 0.05 or p < 0.05.Results: There was no significant difference in the characteristics of the subject at the beginning of the study with average albumin serum level 3.61 ± 0.48 g/dL and creatinine serum level 9.04 ± 2.73 mg/dL. There was no difference in average energy and protein intake of the subject. At the end of the study average albumin serum level was 3.38 ± 0.42 g/dL, creatinine serum level 8.34 ± 3.6 mg/dL, and there was significant difference in albumin serum level (p = 0.000) of the subject. Although there was an increase of creatinine serum level in the group with local catfish filtrate extra diet, it was statistically insignificant.Conclusion: There was significant effect of the supply of commercial formula and local catfish filtrate extra diet to increase of albumin serum level of the subject and there was no significant effect of the supply of extra diet to creatinine serum level; however, the supply of local catfish filtrate extra diet could maintain creatinine serum level.

Hubungan kadar serum albumin dengan kejadian morbiditas dan mortalitas pada pasien penyakit ginjal kronik dengan hemodialisis di RS Dr. Sardjito Yogyakarta

Background: Chronic kidney disease is a characterized by decreasing kidney function with creatine clearance test <15 mL/minute. At such condition toxic in the body accumulates so that dialysis is needed to eliminate it. Blood albumin serum level may indicate nutrition status and is closely related to morbidity and mortality of hemodialysis patients.Objective: To find out association between albumin serum level and occurrence of morbidity and mortality among patients of chronic kidney disease with hemodialysis.Method: The study was observational with prospective cohort design. It was conducted at Dialysis Installation of Dr. Sardjito Hospital from August 2004 to December 2005. Population were all patients of hemodialysis. Samples were purposively taken using inclusion criteria with as many as 44 minimal samples. Dependent variables were morbidity and mortality. Independent variables were albumin serum level, age and long time hemodialysis. Data analysis was done in phases, univariable, and then bivariable.Results: There was association between albumin serum level and morbidity at observation I (p=0.021), observation II (p=0.036), and observation III (p=0.012) which indicated that p<0.05. There was also association between albumin serum level and mortality at observation I (p=0.011), observation II, III and IV (p=0.000) which indicated that p<0.05.Conclusion: There was association between albumin serum level and morbidity and mortality of chronic kidney disease patients with hemodialysis.