Palladium-catalyzed Sonogashira coupling reactions in γ-valerolactone-based ionic liquids

It was demonstrated that the γ-valerolactone-based ionic liquid, tetrabutylphosphonium 4-ethoxyvalerate as a partially bio-based solvent can be utilized as alternative reaction medium for copper- and auxiliary base-free Pd-catalyzed Sonogashira coupling reactions of aryl iodides and functionalized acetylenes under mild conditions. Twenty-two cross-coupling products were isolated with good to excellent yields (72–99%) and purity (>98%). These results represent an example which proves that biomass-derived safer solvents can be utilized efficiently in common, industrially important transformations exhibiting higher chemical and environmental efficiency.

Eco-friendly synthesis of pyridines via rhodium-catalyzed cyclization of diynes with oximes

We describe a new route for the synthesis of pyridines via [2 + 2 + 2] cycloaddition of diynes and oximes catalyzed by Rh(NBD)2BF4/MeO-Biphep using ethanol as an alternative reaction medium, affording the desired pyridine derivatives in yields of up to 93%.