Comparative Pharmaceutical and Analytical Study of Chapal Shodhan (Purification Process) with Special Reference to Bismuth and Selenium

Rasashastra is the branch of science which deals with alchemic preparation or metal and mineral medicinal formulation explained in ancient texts of Ayurved. Rasashastra explained group of drugs in different names on the basis their therapeutic application and binding capacity of drug with Mercury. Chapal one among the group of Maharasa which is having potent therapeutic properties like immune modulator, analgesic, rejuvenator and aphrodisiac. Due to lack of identification, difficulty in procurement and confusion in synonyms and vernacular names, Chapal placed in controversial drugs. Some opines Chapal as Bismuth and some says Selenium. To overcome from these controversies to confirm the type of drug this comparative study is undertaken. Comparative study given nearer conclusion that Chapal can be Selenium, after observing organoleptic properties and symptoms experienced by the person during the purificatory process.

Composition and Quality Standards of Naturally Derived Anti Tan Medicine

Background: Tanning nowadays due to pollution, stress, UV rays, and lifestyle has become a major skincare problem. Synthesis of a poly-herbal anti-tan formulation has been performed in this work, and it is evaluated on various parameters. Objective: The present work is aimed at the synthesis of herb-based anti-tan medicine and the evaluation of its various parameters for its efficiency as well as stability. Materials & Methods: The herbal preparation was prepared in-house according to the proposed composition, using all the natural contents. The dye was evaluated for its different standards. Results: The values of various parameters certified the quality standards of the formulation. The parameters were found to be ample enough for the standardization of herbal medicinal formulation. Conclusion: The prepared herbal pack was found to be appropriate according to all standards and can serve as a better alternative for treating tanning.

Comprehending the Role of Physicians and Counterfeit Medicine in Bangladesh

Counterfeit medicine is a dangerous problem in Bangladesh which make the country's healthcare system in more challenging. For a developing nation like Bangladesh, it is hard to find a perfect solution to curb this problem. According to the World Health Organization (2021), awareness is the key to prevent innocent patient from taking counterfeit medicine. Due to knowledge gap, it's hard for patients to detect the authenticity of medicine because it requires knowledge of medicinal formulation. Physicians of Bangladesh could play a vital role in preventing this counterfeit medicine problem by establishing guidance co-operation relationship with the patients. The study made a literature review of the concept of counterfeit medicine, conducted a bibliometric analysis of counterfeit medicine on Scopus database and provided a relationship flow diagram of prospective guidance relationship between physicians and patients. The study concluded that, this consultation service should be offered by the physicians to the patients and the study expected that, the patient willingly accepts it for getting the safeguard against counterfeit medicine. Keywords: Bibliometric Analysis, Physicians, Patients, Counterfeit Medicine, Bangladesh

Using HPLC–DAD and GC–MS Analysis Isolation and Identification of Anticandida Compounds from Gui Zhen Cao Herbs (Genus Bidens): An Important Chinese Medicinal Formulation

Gui Zhen Cao is an herbal formulation that has been documented in Chinese traditional medicine as a remedy for diarrhea, dysentery, inflammation, and toxicity. The sources of this formulation (Bidens pilosa L., Bidens biternata (Lour.) Merr. & Sherff, Bidens bipinnata L.) are also listed in ethnomedicinal reports all over the world. In this study, all these plants are tested for in vitro anticandida activity. A quantitative evaluation of the phytochemicals in all these plants indicated that their vegetative parts are rich in tannins, saponins, oxalates, cyanogenic glycoside and lipids; moreover, the roots have high percentages of alkaloids, flavonoids, and phenols. The results indicated significant anticandida activity, especially for the hexane extract of B. bipinnata leaves which inhibited C. albicans (42.54%), C. glabrata (46.98%), C. tropicalis (50.89%), C. krusei (40.56%), and C. orthopsilosis (50.24%). The extract was subjected to silica gel chromatography and 220 fractions were obtained. Purification by High Performance Liquid Chromatography with Diode-Array Detection (HPLC–DAD) and Gas Chromatography tandem Mass Spectrometry (GC-MS/MS) analysis led to the identification of two anticandida compounds: dehydroabietic and linoleic acid having an inhibition of 85 and 92%, respectively.

Expository Aspects of Snuhi Tail Preparation

Snuhi plant is a very important therapeutic approaches in Shalyatantra branch among Ashtang Ayurveda with less number of medicinal formulation. The utilization of Snuhi stem for Snuhi Tail preparation contributes towards the management of varicose veins. The Snuhi Tail is used as Abhyanga (Local application) for varicose vein which is supportive mode of management for varicose veins. The preparation of Snuhi Tail and its pharmaceutical analysis is discussed in present research article . The expository review has been made by different samples of Snuhi Tail which was prepared with same materials and methodologies at interval of one year.

Yindan Jiedu Granules, a Traditional Chinese Medicinal Formulation, as a Potential Treatment for Coronavirus Disease 2019

Background:YindanJiedu Granules (YDJDG) have been newly prescribed as a Chinese herbal formula. This study aimed to compare the efficacy of YDJDG and lopinavir-ritonavir in the treatment of coronavirus disease 2019 (COVID-19).Methods: Overall, 131 patients with COVID-19 were included in this study. In addition to standard care, 60 of these patients received YDJDG (YDJDG group) and 71 received lopinavir-ritonavir (lopinavir-ritonavir group). Propensity score matching (PSM) was used to match the characteristics of individuals in the two groups, while the Kaplan-Meier method was used to compare the proportion recovery observed.Results: Cox analysis revealed that YDJDG and CD4 ≥ 660 cells/µL were independent predictive factors of proportion recovery. At baseline, disease types differed between the YDJDG and lopinavir-ritonavir treatment groups. Furthermore, no significant adverse effects or toxicities relevant to YDJDG were observed. The median recovery time was 21 days in the YDJDG group and 27 days in the lopinavir-ritonavir group. After PSM (1:1), 50 patient pairs, YDJDG vs. lopinavir-ritonavir, were analyzed. In the YDJDG group, the proportion of recovered patients was remarkably higher than that observed in the lopinavir-ritonavir group (p = 0.0013), especially for those presenting mild/moderate disease type and CD4 < 660 cells/µL. In the YDJDG group, the mean duration of fever and pulmonary exudative lesions was significantly shorter than that observed in the lopinavir-ritonavir group (p = 0.0180 and p = 0.0028, respectively).Conclusion: YDJDG reveals the potential to hasten the recovery period in COVID-19 patients with mild/moderate disease type or CD4 < 660 cells/µL by shortening the mean duration of fever and pulmonary exudative lesions.