Exploring the putative mechanism of allosteric modulations by mixed-action kappa/mu opioid receptor bitopic modulators

The modulation and selectivity mechanisms of seven mixed-action kappa opioid receptor (KOR)/mu opioid receptor (MOR) bitopic modulators were explored. Molecular modeling results indicated that the ‘message’ moiety of seven bitopic modulators shared the same binding mode with the orthosteric site of the KOR and MOR, whereas the ‘address’ moiety bound with different subdomains of the allosteric site of the KOR and MOR. The ‘address’ moiety of seven bitopic modulators bound to different subdomains of the allosteric site of the KOR and MOR may exhibit distinguishable allosteric modulations to the binding affinity and/or efficacy of the ‘message’ moiety. Moreover, the 3-hydroxy group on the phenolic moiety of the seven bitopic modulators induced selectivity to the KOR over the MOR.

Lattice QCD with mixed action – Borici-Creutz valence quark on staggered sea

Mixed action lattice QCD with Borici-Creutz valence quarks on staggered sea is investigated. The counter terms in Borici-Creutz action are fixed nonperturbatively to restore the broken symmetries. On symmetry restoration, the usual signatures of partial quenching / unitarity violation like negative scalar correlator are observed. The size of unitarity violation due to different discretization of valence and sea quark is determined by measuring Δmix.

A tmQCD mixed-action approach to flavour physics

We discuss a mixed-action approach in which sea quarks are regularised using non-perturbatively O(a) improved Wilson fermions, while a fully-twisted tmQCD action is used for valence quarks. In this setup, automatic O(a) improvement is preserved for valence observables, apart from small residual O(a) effects from the sea. A strategy for matching sea and valence is set up, and carried out for Nf = 2 + 1 CLS ensembles with open boundary conditions at several simulation points. The scaling of basic light-quark observables such as the pseudoscalar meson decay constant is studied, as well as the isospin splitting of pseudoscalar meson masses.

Mixed Policies

This chapter explores the concept of mixed policies and how the notions for pure policies can be adapted to this more general type of policies. A pure policy consists of choices of particular actions (perhaps based on some observation), whereas a mixed policy involves choosing a probability distribution to select actions (perhaps as a function of observations). The idea behind mixed policies is that the players select their actions randomly according to a previously selected probability distribution. The chapter first considers the rock-paper-scissors game as an example of mixed policy before discussing mixed action spaces, mixed security policy and saddle-point equilibrium, mixed saddle-point equilibrium vs. average security levels, and general zero-sum games. It concludes with practice exercises with corresponding solutions and an additional exercise.

When do language comprehenders mentally simulate locations?

Embodied approaches to comprehension propose that understanding language entails performing mental simulations of its content. The evidence, however, is mixed. Action-sentence Compatibility Effect studies (Glenberg and Kaschak 2002) report mental simulation of motor actions during processing of motion language. But the same studies find no evidence that language comprehenders perform spatial simulations of the corresponding locations. This challenges simulation-based approaches. If locations are not represented in simulation, but are still understood, then simulation may be unnecessary for understanding. We conducted a Location-sentence Compatibility experiment, to determine whether understanders mentally simulate locations. People did indeed simulate locations, but only when sentences used progressive (and not perfect) grammatical aspect. Moreover, mental simulations of locations differed for language about concrete versus abstract events. These findings substantiate the role of mental simulation in language understanding, while highlighting the importance of the grammatical form of utterances as well as their content.