Brain Invasion in Meningioma—A Prognostic Potential Worth Exploring

Most meningiomas are slow growing tumors arising from the arachnoid cap cells and can be cured by surgical resection or radiation therapy in selected cases. However, recurrent and aggressive cases are also quite common and challenging to treat due to no established treatment alternatives. Assessment of the risk of recurrence is therefore of utmost importance and several prognostic clinical and molecular markers have been established. Additionally, the identification of invasive growth of meningioma cells into CNS tissue was demonstrated to lead to a higher risk of recurrence and was therefore integrated into the WHO classification of CNS tumors. However, the evidence for its prognostic impact has been questioned in subsequent studies and its exclusion from the next WHO classification proposed. We were recently able to show the prognostic impact of CNS invasion in a large comprehensive retrospective meningioma cohort including other established prognostic factors. In this review we discuss the growing experiences that have been gained on this matter, with a focus on the currently nonuniform histopathological assessment, imaging characteristics and intraoperative sampling as well as the overall outlook on the future role of this potential prognostic factor.

Life cycle based alternatives assessment (LCAA) for chemical substitution

We developed a Life Cycle based Alternatives Assessment (LCAA) framework for efficiently including quantitative exposure and life cycle impacts in chemical substitution studies.

Building shared information infrastructure for chemical alternatives assessment

The substitution of hazardous substances with safer alternatives is being driven by policy pressures and business demands. As a result, scientific techniques for chemical alternatives assessment (CAA) have been established and communities of practice are emerging. Interest in safer chemical substitution is widely shared throughout a range of stakeholder groups across science, industry, public policy, and advocacy. Yet there is an unmet need for intentionally designed public information infrastructure to support the highly knowledge-intensive nature of CAA. We report here on the process of developing the Chemical Hazard Data Commons, an experimental project intended to support a diverse community of practitioners by providing publicly accessible chemical hazard data and tools for understanding it. In an arena where market forces and regulatory regimes have largely failed to generate the necessary knowledge, this project represents a novel application of a commons-based approach emphasizing building shared intellectual and technical capacity for CAA. The Data Commons—now a part of the related Pharos Project—includes an online portal providing simultaneous access to many different sources of information and enabling effective interactions with it. Foremost among these interactions are search and retrieval of hazard information about chemical substances, uniform display of the most relevant information, and the ability to automatically screen substances against consistent and transparent hazard-based criteria. We describe the motivation for the project and report on the principles and key considerations that guided its design as a participatory information infrastructure. We present our approach to organizing chemical information; the process of community engagement and planning; and how we constructed the system to provide functional tools. We discuss the outcomes of the project and highlight important challenges—such as fostering active participation and planning for long-term governance. With this article, we hope to inform future efforts for the collaborative development of knowledge resources for chemical alternatives assessment.