foxa transcription factors
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2020 ◽  
Author(s):  
Yitzhak Reizel ◽  
Ashleigh Morgan ◽  
Long Gao ◽  
Yemin Lan ◽  
Elisabetta Manduchi ◽  
...  

AbstractThe FoxA transcription factors are critical for liver development through their pioneering activity, which initiates a highly complex regulatory network thought to become progressively resistant to the loss of any individual hepatic transcription factor via mutual redundancy. To investigate the dispensability of FoxA factors for maintaining this regulatory network, we ablated all FoxA genes in the adult mouse liver. Remarkably, loss of FoxA caused rapid hepatocyte dedifferentiation manifested by a massive reduction in the expression of key liver genes. Interestingly, expression of these genes was reduced back to the low levels of the fetal prehepatic endoderm stage, leading to necrosis and lethality within days. Mechanistically, we found FoxA proteins to be required for maintaining enhancer activity, chromatin accessibility, nucleosome positioning and binding by HNF4α. Thus, the FoxA factors act continuously, guarding hepatic enhancer activity throughout life.


2018 ◽  
Vol 110 (4) ◽  
pp. e307
Author(s):  
D. Prokai ◽  
A. Moehlman ◽  
K. Chapman ◽  
J. Chaudhary ◽  
A. Pudasaini ◽  
...  

2011 ◽  
Vol 152 (1) ◽  
pp. 101-104
Author(s):  
M. Yu. Pakharukova ◽  
M. A. Smetanina ◽  
S. I. Ilnitskaya ◽  
V. I. Kaledin ◽  
T. I. Merkulova

2011 ◽  
Vol 350 (2) ◽  
pp. 484-495 ◽  
Author(s):  
Sophie Dal-Pra ◽  
Christine Thisse ◽  
Bernard Thisse

2008 ◽  
Vol 73 (1) ◽  
pp. 70-75 ◽  
Author(s):  
L. O. Bryzgalov ◽  
N. I. Ershov ◽  
D. Yu. Oshchepkov ◽  
V. I. Kaledin ◽  
T. I. Merkulova

Nature ◽  
2005 ◽  
Vol 435 (7044) ◽  
pp. 944-947 ◽  
Author(s):  
Catherine S. Lee ◽  
Joshua R. Friedman ◽  
James T. Fulmer ◽  
Klaus H. Kaestner

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