The initiation of liver development is dependent on Foxa transcription factors

Nature ◽  
2005 ◽  
Vol 435 (7044) ◽  
pp. 944-947 ◽  
Author(s):  
Catherine S. Lee ◽  
Joshua R. Friedman ◽  
James T. Fulmer ◽  
Klaus H. Kaestner
Keyword(s):  
Transcription Factors ◽  
Liver Development ◽  
Foxa Transcription Factors

OAT and 3’MeDAB Azo Compounds Similarly Cause Liver Tumors in GR Mice, but Differently Modify Activities of FoxA Transcription Factors

2011 ◽  
Vol 152 (1) ◽  
pp. 101-104
Author(s):  
M. Yu. Pakharukova ◽  
M. A. Smetanina ◽  
S. I. Ilnitskaya ◽  
V. I. Kaledin ◽  
T. I. Merkulova
Keyword(s):  
Transcription Factors ◽  
Liver Tumors ◽  
Azo Compounds ◽  
Foxa Transcription Factors

scholarly journals Pioneering roles for FOXA transcription factors in rat stem and progenitor spermatogonia

2018 ◽  
Vol 110 (4) ◽  
pp. e307
Author(s):  
D. Prokai ◽  
A. Moehlman ◽  
K. Chapman ◽  
J. Chaudhary ◽  
A. Pudasaini ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Foxa Transcription Factors

scholarly journals Liver-enriched transcription factors regulate MicroRNA-122 that targets CUTL1 during liver development

Hepatology ◽  
2010 ◽  
Vol 52 (4) ◽  
pp. 1431-1442 ◽  
Author(s):  
Hui Xu ◽  
Jie-Hua He ◽  
Zhen-Dong Xiao ◽  
Qian-Qian Zhang ◽  
Yue-Qin Chen ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Liver Development

scholarly journals Bookmarking by Non-pioneer Transcription Factors during Liver Development Establishes Competence for Future Gene Activation

Cell Reports ◽  
2020 ◽  
Vol 30 (5) ◽  
pp. 1319-1328.e6 ◽  
Author(s):  
Panagiota Karagianni ◽  
Panagiotis Moulos ◽  
Dominic Schmidt ◽  
Duncan T. Odom ◽  
Iannis Talianidis
Keyword(s):  
Transcription Factors ◽  
Gene Activation ◽  
Liver Development

Cooperation between Transcription Factors Regulates Liver Development

Neonatology ◽  
1995 ◽  
Vol 67 (6) ◽  
pp. 387-396 ◽  
Author(s):  
Adi Aran ◽  
Hanoch Cassuto ◽  
Lea Reshef
Keyword(s):  
Transcription Factors ◽  
Liver Development

scholarly journals Transcription Control of Liver Development

Cells ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 2026
Author(s):  
Evangelia C. Tachmatzidi ◽  
Ourania Galanopoulou ◽  
Iannis Talianidis
Keyword(s):  
Transcription Factors ◽  
Target Genes ◽  
Expression Profiles ◽  
Gene Activation ◽  
Condensed Chromatin ◽  
Liver Development ◽  
Transcription Control ◽  
Memory Mechanism ◽  
Hepatic Expression ◽  
Pioneer Factors

During liver organogenesis, cellular transcriptional profiles are constantly reshaped by the action of hepatic transcriptional regulators, including FoxA1-3, GATA4/6, HNF1α/β, HNF4α, HNF6, OC-2, C/EBPα/β, Hex, and Prox1. These factors are crucial for the activation of hepatic genes that, in the context of compact chromatin, cannot access their targets. The initial opening of highly condensed chromatin is executed by a special class of transcription factors known as pioneer factors. They bind and destabilize highly condensed chromatin and facilitate access to other “non-pioneer” factors. The association of target genes with pioneer and non-pioneer transcription factors takes place long before gene activation. In this way, the underlying gene regulatory regions are marked for future activation. The process is called “bookmarking”, which confers transcriptional competence on target genes. Developmental bookmarking is accompanied by a dynamic maturation process, which prepares the genomic loci for stable and efficient transcription. Stable hepatic expression profiles are maintained during development and adulthood by the constant availability of the main regulators. This is achieved by a self-sustaining regulatory network that is established by complex cross-regulatory interactions between the major regulators. This network gradually grows during liver development and provides an epigenetic memory mechanism for safeguarding the optimal expression of the regulators.

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