Central mucoepidermoid carcinoma arising directly from a glandular odontogenic cyst of the mandible: a case report

Background Central mucoepidermoid carcinoma (MEC) is a rare salivary gland tumor that affects the jawbone. Glandular odontogenic cyst (GOC) is also a rare odontogenic developmental cyst with glandular differentiation. GOC shares some histological features with central MEC, and a pre-existing GOC can develop into central MEC. Here, we present a rare case of central MEC developed directly from a pre-existing GOC of the mandible. Case presentation A 67-year-old Japanese man presented with a cystic lesion in the right third molar region. Histologically, the biopsy specimen demonstrated both typical findings of a GOC component lined with non-keratinized squamous epithelium and a recognizable component of central MEC consisting of polycystic nests with mucous cells, intermediate cells, and epidermoid cells in the cyst wall. The results from the immunohistochemistry for cytokeratin (CK) profiling demonstrated that, while both central MEC and GOC expressed CKs 7, 14, 18, and 19, CK13 was interestingly exclusively expressed in GOC. Fluorescence in-situ hybridization (FISH) revealed the rearrangement of the Mastermind like (MAML)-2 gene in both the MEC and GOC components. Conclusions Our case suggests that central MEC and GOC may be in the same spectrum of diseases caused by the rearrangement of the MAML-2 gene. However, given that the expression profile of CK13 was completely different between central MEC and GOC, they can be considered as separate tumors. Overall, we demonstrated a rare case in which central MEC may have originated directly from the GOC.

Central Mucoepidermoid Carcinoma Arising Directly From a Glandular Odontogenic Cyst of the Mandible: A Case Report

BackgroundCentral mucoepidermoid carcinoma (MEC) is a rare salivary gland tumor that affects the jaw bone. Glandular odontogenic cyst (GOC) is also a rare odontogenic developmental cyst with glandular differentiation. GOC shares some histological features with central MEC, and a pre-existing GOC can develop into central MEC. Here, we present a rare case of central MEC developed directly from a pre-existing GOC of the mandible. Case presentationA 67-year-old Japanese man presented with a cystic lesion in the right third molar region. Histologically, the biopsy specimen demonstrated both typical of a GOC component lined with non-keratinized squamous epithelium and a recognizable component of central MEC consisting of polycystic nests with mucous cells, intermediate cells, and epidermoid cells in the cyst wall. The immunohistochemistry for cytokeratin (CK) profile results demonstrated that while both central MEC and GOC expressed CKs 7, 14, 18, and 19, interestingly CK13 was only expressed in GOC. Fluorescence in-situ hybridization (FISH) revealed the rearrangement of the Mastermind like (MAML)-2 gene in both MEC and GOC components. ConclusionsOur case suggests that central MEC and GOC may be in the same spectrum of diseases caused by rearrangement of the MAML-2 gene. At the same time, the expression profile of CK13 was completely different in both central MEC and GOC. This also suggests that central MEC is a distinct tumor from GOC. Thus, we demonstrated the rare case that central MEC may have originated directly from the GOC.

Prótese bucomaxilofacial: a Odontologia além da boca

A prótese bucomaxilofacial é uma especialidade da Odontologia que visa restaurar indivíduos com perda de estrutura na região de boca e face. Seu ensino ainda é restrito na maioria dos cursos de Odontologia no Brasil, de modo que os cirurgiões dentistas se formam sem conhecer este ramo tão bonito da reabilitação e sem o domínio de conhecimentos teóricos e técnicos sobre o assunto. Deste modo, o objetivo do presente trabalho foi realizar uma revisão de literatura acerca da especialidade de prótese bucomaxilofacial para guiar os cirurgiões-dentistas a respeito de sua indicação, tipos, materiais utilizados e técnica de confecção.Descritores: Prótese Maxilofacial; Prótese Dentária; Reabilitação.ReferênciasAlfenas ER, Lanza CRM, Barreiros ID, Novaes Junior JB, Mendonça LL. Reabilitação protética do paciente com perda de substância na região de cabeça e pescoço. 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