Desejo da maternidade entre mulheres com insuficiência renal crônica dialítica

A Doença Renal Crônica consiste em uma lesão renal com perda progressiva e irreversível da função renal. Devido à gravidade da doença torna-se muito difícil a concepção e manutenção de uma gravidez. O objetivo foi verificar a percepção e desejo de engravidar em um grupo de mulheres com insuficiência renal crônica em terapia renal substitutiva dialítica. Trata-se de um estudo descritivo, com abordagem qualitativa realizado no Instituto Capixaba de Doenças Renais e Hipertensão LTDA, situado em Cariacica-ES. Os dados foram coletados em outubro de 2017, através de uma entrevista semiestruturada e 10 mulheres participaram da pesquisa. Análise de conteúdo, seguindo os momentos metodológicos propostos por Bardin. Constatou-se que mais de 50% das entrevistadas possuem o desejo de engravidar. Necessitam de um cuidado rigoroso da equipe multiprofissional abrangendo a mulher de forma holística e que o pré-natal seja iniciado o mais precoce possível.Descritores: Enfermagem, Insuficiência Renal Crônica, Gravidez de Alto Risco. Wish of motherhood among women with chronic kidney insufficiency dialyticAbstract: Chronic Kidney Disease consists of a kidney injury with progressive and irreversible loss of renal function. Due to the severity of the disease it becomes very difficult to conceive and maintain a pregnancy. The objective was to verify the perception and desire to become pregnant in a group of women with chronic renal failure in dialysis renal replacement therapy. This is a descriptive study, with a qualitative approach carried out at the Instituto Capixaba de Doenças Renais e Hipertensão LTDA, located in Cariacica-ES. Data were collected in October 2017, through a semi-structured interview and 10 women participated in the research. Content analysis, following the methodological moments proposed by Bardin. It was found that more than 50% of the women interviewed had the desire to become pregnant. They need a rigorous care of the multiprofessional team covering the woman holistically and that prenatal care be started as early as possible.Descriptors: Nursing, Chronic Renal Insufficiency, High-Risk Pregnancy. Deseo de la maternidade entre mujeres com insuficiencia renal crónica dialíticaResumen: La enfermedad renal crónica consiste en una lesión renal con pérdida progresiva e irreversible de la función renal. Debido a la gravedad de la enfermedad se vuelve muy difícil el diseño y el mantenimiento de un embarazo. El objetivo fue verificar la percepción y deseo de quedar embarazada en un grupo de mujeres con insuficiencia renal crónica en terapia renal sustitutiva dialítica. Se trata de un estudio descriptivo, con abordaje cualitativo realizado en el Instituto Capixaba de Enfermedades Renales e Hipertensión LTDA, situado en Cariacica-ES. Los datos fueron recolectados en octubre de 2017, a través de una entrevista semiestructurada y 10 mujeres participaron en la investigación. Análisis de contenido, siguiendo los momentos metodológicos propuestos por Bardin. Se constató que más del 50% de las entrevistadas poseen el deseo de quedar embarazadas. Necesitan un cuidado riguroso del equipo multiprofesional que abarca a la mujer de forma holística y que el prenatal se inicie lo más temprano posible.Descriptores: Enfermería, Insuficiencia Renal Crónica, Embarazo de Alto Riesgo.

Desejo da maternidade entre mulheres com insuficiência renal crônica dialítica

A Doença Renal Crônica consiste em uma lesão renal com perda progressiva e irreversível da função renal. Devido à gravidade da doença torna-se muito difícil a concepção e manutenção de uma gravidez. O objetivo foi verificar a percepção e desejo de engravidar em um grupo de mulheres com insuficiência renal crônica em terapia renal substitutiva dialítica. Trata-se de um estudo descritivo, com abordagem qualitativa realizado no Instituto Capixaba de Doenças Renais e Hipertensão LTDA, situado em Cariacica-ES. Os dados foram coletados em outubro de 2017, através de uma entrevista semiestruturada e 10 mulheres participaram da pesquisa. Análise de conteúdo, seguindo os momentos metodológicos propostos por Bardin. Constatou-se que mais de 50% das entrevistadas possuem o desejo de engravidar. Necessitam de um cuidado rigoroso da equipe multiprofissional abrangendo a mulher de forma holística e que o pré-natal seja iniciado o mais precoce possível.Descritores: Enfermagem, Insuficiência Renal Crônica, Gravidez de Alto Risco. Wish of motherhood among women with chronic kidney insufficiency dialyticAbstract: Chronic Kidney Disease consists of a kidney injury with progressive and irreversible loss of renal function. Due to the severity of the disease it becomes very difficult to conceive and maintain a pregnancy. The objective was to verify the perception and desire to become pregnant in a group of women with chronic renal failure in dialysis renal replacement therapy. This is a descriptive study, with a qualitative approach carried out at the Instituto Capixaba de Doenças Renais e Hipertensão LTDA, located in Cariacica-ES. Data were collected in October 2017, through a semi-structured interview and 10 women participated in the research. Content analysis, following the methodological moments proposed by Bardin. It was found that more than 50% of the women interviewed had the desire to become pregnant. They need a rigorous care of the multiprofessional team covering the woman holistically and that prenatal care be started as early as possible.Descriptors: Nursing, Chronic Renal Insufficiency, High-Risk Pregnancy. Deseo de la maternidade entre mujeres com insuficiencia renal crónica dialíticaResumen: La enfermedad renal crónica consiste en una lesión renal con pérdida progresiva e irreversible de la función renal. Debido a la gravedad de la enfermedad se vuelve muy difícil el diseño y el mantenimiento de un embarazo. El objetivo fue verificar la percepción y deseo de quedar embarazada en un grupo de mujeres con insuficiencia renal crónica en terapia renal sustitutiva dialítica. Se trata de un estudio descriptivo, con abordaje cualitativo realizado en el Instituto Capixaba de Enfermedades Renales e Hipertensión LTDA, situado en Cariacica-ES. Los datos fueron recolectados en octubre de 2017, a través de una entrevista semiestructurada y 10 mujeres participaron en la investigación. Análisis de contenido, siguiendo los momentos metodológicos propuestos por Bardin. Se constató que más del 50% de las entrevistadas poseen el deseo de quedar embarazadas. Necesitan un cuidado riguroso del equipo multiprofesional que abarca a la mujer de forma holística y que el prenatal se inicie lo más temprano posible.Descriptores: Enfermería, Insuficiencia Renal Crónica, Embarazo de Alto Riesgo.

Urinary Clusterin Is Upregulated in Nephropathia Epidemica

Kidney insufficiency is a hallmark of nephropathia epidemica (NE). Little is known about the mechanisms of the NE kidney pathology, with current knowledge mainly based on findings in postmortem tissue. We have analyzed kidney damage biomarkers in urine collected from early- and late-phase NE using Bio-Plex kidney toxicity panels 1 and 2. To determine the disease specificity, kidney damage biomarkers were also analyzed in urine samples from patients diagnosed with gout, type 2 diabetes, systemic lupus erythematosus, and chronic kidney insufficiency. Analysis of 12 biomarkers suggests damage to the kidney proximal tubule at the onset of NE. Also, upregulation of biomarkers of inflammation and leukocyte chemotaxis were detected in NE urine. Furthermore, increased clusterin levels were found in early- and late-phase NE urine. Comparative analysis revealed that clusterin is a biomarker, upregulated in NE urine.

Activity of selected aromatic amino acids in biological systems.

Besides the structural function in proteins, aromatic amino acids are precursors of many important biological compounds essential for normal functioning of the human organism. Many of these compounds may be used as markers for identification of specific pathological states. Comprehensive knowledge about the metabolism of aromatic amino acids and mechanisms of action of their metabolites made it possible to develop effective treatments for many disorders. However, it should not be forgotten that in some pathological conditions, these compounds could not only be involved in the pathogenesis of many disease entities but could also be used as an important tool in prediction of many diseases. This paper contains a review of published literature on aromatic amino acids in the context of physiological processes of the human body and chosen social disorders, such as cancers; psychiatric disorders: depression, anxiety states, schizophrenia, bipolar affective disorders; neurodegenerative, and cardiovascular diseases; chronic kidney insufficiency or diabetes.

Prevention Of Chronic Renal Diseases

It is easier to prevent a disease than to cure it. This postulate is a foundation stone of the contemporary medicine, furthermore its mission. The Chronic Kidney Diseases (CKD), amongst them the Chronic Pyelonephrites (CP) and the mass kidney reduction take an important place in human pathologies in general, and in particular in renal ones. The Chronic Pyelonephrites are chronic renal pathologies, which on one side are of various causes and on the other side are multi systemic. At the same time they tend, earlier or later, depending on their course, to bring the patient towards the Chronic Kidney Insufficiency in stage of uremia, consequently in need of substitution therapies e.g. dialysis, peritoneum dialysis or transplant. It is worthy to emphasize that from the prevention and correct cure of CP make profit the patients, the family, the state and in the last analyses the entire society, because in that way the budget expense destined for the fore going substitution cures, dialysis, peritoneum dialysis or transplant, is considerably reduced. The same should be mentioned in relation to the CP and the mass kidney reduction, speaking about our country, which are still at the first place as the very cause of Chronic Kidney Insufficiencies (CRI), later on advancing toward uremia and terminal uremia along with its grave consequences. In general the very foundation of the CP is on the infections of urinary roads, in particular on the complicated ones, among them it should be mentioned-congenital kidney anomalies, renal calculosis so much present in our country, and pathologies of segment or vesical-ureteral reflux, and rarely the pathologies of prostate.