Topological Characteristics Associated with Intraoperative Stimulation Related Epilepsy of Glioma Patients: A DTI Network Study

Background: Awake craniotomy with intraoperative stimulation has been utilized in glioma surgical resection to preserve the quality of life. Epilepsy may occur in 5–20% of cases, leading to severe consequences. This study aimed to discuss the mechanism of intraoperative stimulation-related epilepsy (ISE) using DTI-based graph theoretical analysis. Methods: Twenty patients with motor-area glioma were enrolled and divided into two groups (Ep and nEp) according to the presence of ISE. Additionally, a group of 10 healthy participants matched by age, sex, and years of education was also included. All participants underwent T1, T2, and DTI examinations. Graph theoretical analysis was applied to reveal the topological characteristics of white matter networks. Results: Three connections were found to be significantly lower in at least one weighting in the Ep group. These connections were between A1/2/3truL and A4ulL, A1/2/3truR and A4tR, and A6mL and A6mR. Global efficiency was significantly decreased, while the shortest path length increased in the Ep group in at least one weighting. Ten nodes exhibited significant differences in nodal efficiency and degree centrality analyses. The nodes A6mL and A6mR showed a marked decrease in total four weightings in the Ep group. Conclusions: The hub nodes A6mL and A6mR are disconnected in patients with ISE, causing subsequent lower efficiency of global and regional networks. These findings provide a basis for presurgical assessment of ISE, for which caution should be taken when it involves hub nodes during intraoperative electrical stimulation.

Ten Measurements That Can Reduce Anxiety in Physicians and Their Patients Undergoing Breast Augmentation Surgery

There are numerous measuring systems that practitioners employ as part of their presurgical assessment for breast implant surgery. These range from direct measurements of patients using a tape measure, to assessment of standardized photographs and 3-dimensional scanning technologies. This personal view describes the authors system, developed over 20 years. The data yielded have assisted in assessing breast symmetry, ptosis, and match of implant to patient, with proven benefits for managing patient outcomes and expectations. It is simple, rapid to undertake, and requires inexpensive measuring equipment to provide useful data.

Injuries during Laparoscopic Cholecystectomy: A Scoping Review of the Claims and Civil Action Judgements

Background. To define what type of injuries are more frequently related to medicolegal claims and civil action judgments. Methods. We performed a scoping review on 14 studies and 2406 patients, analyzing medicolegal claims related to laparoscopic cholecystectomy injuries. We have focalized on three phases associated with claims: phase of care, location of injuries, type of injuries. Results. The most common phase of care associated with litigation was the improper intraoperative surgical performance (47.6% ± 28.3%), related to a “poor” visualization, and the improper post-operative management (29.3% ± 31.6%). The highest rate of defense verdicts was reported for the improper post-operative management of the injury (69.3% ± 23%). A lower rate was reported in the incorrect presurgical assessment (39.7% ± 24.4%) and in the improper intraoperative surgical performance (21.39% ± 21.09%). A defense verdict was more common in cystic duct injuries (100%), lower in hepatic bile duct (42.9%) and common bile duct (10%) injuries. Conclusions. During laparoscopic cholecystectomy, the most common cause of claims, associated with lower rate of defense verdict, was the improper intraoperative surgical performance. The decision to take legal action was determined often for poor communication after the original incident.

Digital Semiology: A Prototype for Standardized, Computer-Based Semiologic Encoding of Seizures

Video-EEG monitoring (VEM) is imperative in seizure classification and presurgical assessment of epilepsy patients. Analysis of VEM is currently performed in most institutions using a freeform report, a time-consuming process resulting in a non-standardized report, limiting the use of this essential diagnostic tool. Herein we present a pilot feasibility study of our experience with “Digital Semiology” (DS), a novel seizure encoding software. It allows semiautomated annotation of the videos of suspected events from a predetermined, hierarchal set of options, with highly detailed semiologic descriptions, somatic localization, and timing. In addition, the software's semiologic extrapolation functions identify characteristics of focal seizures and PNES, sequences compatible with a Jacksonian march, and risk factors for SUDEP. Sixty episodes from a mixed adult and pediatric cohort from one level 4 epilepsy center VEM archives were analyzed using DS and the reports were compared with the standard freeform ones, written by the same epileptologists. The behavioral characteristics appearing in the DS and freeform reports overlapped by 78–80%. Encoding of one episode using DS required an average of 18 min 13 s (standard deviation: 14 min and 16 s). The focality function identified 19 out of 43 focal episodes, with a sensitivity of 45.45% (CI 30.39–61.15%) and specificity of 87.50% (CI 61.65–98.45%). The PNES function identified 6 of 12 PNES episodes, with a sensitivity of 50% (95% CI 21.09–78.91%) and specificity of 97.2 (95% CI 88.93–99.95%). Eleven events of GTCS triggered the SUDEP risk alert. Overall, these results show that video recordings of suspected seizures can be encoded using the DS software in a precise manner, offering the added benefit of semiologic alerts. The present study represents an important step toward the formation of an annotated video archive, to be used for machine learning purposes. This will further the goal of automated VEM analysis, ultimately contributing to wider utilization of VEM and therefore to the reduction of the treatment gap in epilepsy.

Topological Characteristics Associated with Intraoperative Stimulation Related Epilepsy of Glioma Patients: A DTI Network Study

Purpose Awake craniotomy with intraoperative stimulation has been utilized in glioma surgical resection to preserve life quality. While 5-20% of cases may occur epilepsy during the procedure which leads to severe consequences. The study aimed to discussing the mechanism of intraoperative stimulation-related epilepsy (ISE) with DTI based graph theoretical analysis.Methods 20 patients with motor-area glioma were enrolled and divided into 2 groups (Ep and nEp) according to whether there was ISE. Additionally, a group of 10 healthy participants matched by age, gender and education year were also involved. All participants underwent T1, T2 and DTI. Graph theoretical analysis was applied to reveal topological characteristics of the white matter networks. Results Three connections were found to be significantly lower in at least one weighting in Ep group. They are the connection between A1/2/3truL and A4ulL, A1/2/3truR and A4tR, and A6mL and A6mR. Global efficiency was found to be significantly decreased while the shortest path length increased in Ep group in at least one weighting. Ten nodes exhibited significant difference in the nodal efficiency and degree centrality analysis. The nodes A6mL and A6mR showed markable decrease in total four weightings in Ep group.Conclusion The hub nodes A6mL and A6mR, get disconnected in the patients with ISE, causing subsequent lower efficiency of global and regional network. The findings provide basis for presurgical assessment of ISE, for that caution should be taken when it involves hub nodes during intraoperative electrical stimulation.

Lingual Foramen of the Mandible on Cone-Beam Computed Tomography Scans: A Study of Anatomical Variations in an Iranian Population

Objectives: Lingual foramen (LF) is an important landmark of the mandible, which should be considered in presurgical assessment. The purpose of this study was to assess the anatomical variations of the LF using cone-beam computed tomography (CBCT). Materials and Methods: The study was conducted on 200 CBCT scans of Iranian adults. The lingual foramina (LFs) were classified into two groups by their location in the mandible namely the medial LFs (MLFs) and the lateral LFs (LLFs). The frequency of both the MLFs and the LLFs and their distance from the inferior border of the mandible were evaluated. Additionally, the diameter of the MLFs and the location of the LLFs were assessed. Data were analyzed separately for males and females. Results: All 200 participants had at least one LF. Totally, 257 LFs were detected on 200 CBCT scans, including 223 MLFs (86.6%) and 34 LLFs (13.3%). The LLF was detected in 23 patients (11.5%). The prevalence of the LLF was higher in males and in the second premolar region. The diameter of the MLFs was less than 1mm in 81% of the cases, and males had a larger MLF. Conclusion: There was a significant variability in the anatomy and location of the mandibular LF in Iranian adults. CBCT is recommended for preoperative imaging to determine the exact location and size of the LFs in the mandible to prevent possible surgical complications.