cardiac muscle mechanics
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2019 ◽  
Vol 662 ◽  
pp. 213-218 ◽  
Author(s):  
Ranganath Mamidi ◽  
Jiayang Li ◽  
Chang Yoon Doh ◽  
Joshua B. Holmes ◽  
Julian E. Stelzer

2018 ◽  
pp. 91-99
Author(s):  
Nicolaas Westerhof ◽  
Nikolaos Stergiopulos ◽  
Mark I. M. Noble ◽  
Berend E. Westerhof

2018 ◽  
Vol 114 (3) ◽  
pp. 502a
Author(s):  
Karissa M. Dieseldorff Jones ◽  
David Gonzalez-Martinez ◽  
Maicon Landim-Vieira ◽  
Yeojung Koh ◽  
Bjorn C. Knollmann ◽  
...  

2010 ◽  
pp. 69-76 ◽  
Author(s):  
Nicolaas Westerhof ◽  
Nikolaos Stergiopulos ◽  
Mark I. M. Noble

2001 ◽  
Vol 281 (3) ◽  
pp. H1442-H1446 ◽  
Author(s):  
So-Ichiro Yasuda ◽  
Seiryo Sugiura ◽  
Naoshi Kobayakawa ◽  
Hideo Fujita ◽  
Hiroshi Yamashita ◽  
...  

To facilitate cardiac muscle research, we developed a novel method by which the force and length of a single ventricular myocyte can be recorded with a pair of carbon graphite fibers attached firmly to both ends. One fiber was stiff, whereas the other fiber was compliant to allow the recording of force and shortening during twitch contractions. The image of the compliant carbon fiber was projected onto a pair of photodiodes, and their output was fed to a piezoelectric transducer after variable amplifications to alter the effective compliance of the carbon fiber. Thus contraction of the myocyte was induced under virtually isometric conditions as well as under auxotonic conditions. We obtained a bell-shaped relation between the compliance under an auxotonic load and the work output of the myocyte, which was directly related to myocyte performance in the heart. Because it is easy to attach myocytes to the experimental apparatus, the present method would allow us to study cardiac muscle mechanics at the cellular and molecular levels.


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