Cardiac Muscle Mechanics. Richard A. Meiss

1989 ◽  
Vol 64 (2) ◽  
pp. 248-248
Author(s):  
Bernard D. Tunik
Keyword(s):  
Cardiac Muscle ◽  
Muscle Mechanics ◽  
Cardiac Muscle Mechanics

scholarly journals Cardiac muscle mechanics in hyperosmotic solutions

1970 ◽  
Vol 218 (6) ◽  
pp. 1800-1800
Author(s):  
K. Wildenthal ◽  
C. L. Skelton ◽  
H. N. Coleman
Keyword(s):  
Cardiac Muscle ◽  
Muscle Mechanics ◽  
Cardiac Muscle Mechanics

Page 302: K. Wildenthal, C. L. Skelton, and H. N. Coleman III. "Cardiac muscle mechanics in hyperosmotic solutions." Page 304, legend to Fig. 2, line 7 should read, "for control, and P = 0.2( e1.9l – 1)/1.9 for hyperosmolality, when calculated as the means of P and l values from individual experiments." Page 304, column 2, line 8, and Page 305, column 1, line 27, the equation should read, " P – C( eKl – 1)/ K."

Cardiac muscle mechanics and ventricular performance: force and time parameters

1964 ◽  
Vol 207 (3) ◽  
pp. 705-715 ◽  
Author(s):  
S. Evans Downing ◽  
Edmund H. Sonnenblick
Keyword(s):  
Stroke Volume ◽  
Cardiac Muscle ◽  
Papillary Muscle ◽  
Diastolic Pressure ◽  
Muscle Mechanics ◽  
Muscle Length ◽  
Maximal Velocity ◽  
Cardiac Muscle Mechanics ◽  
Resting Muscle ◽  
Intact Heart

Studies were designed to determine parameters of force and velocity derived from isolated cardiac muscle mechanics which would permit comparison with related performance characteristics in the intact ventricle. In the papillary muscle, for a wide range of resting muscle lengths, tension developed isometrically (Po) was found a linear function of initial muscle length and proportional to the extent of isotonic shortening (δL). Length-tension curves obtained isotonically were virtually identical to those obtained isometrically. In the intact heart stroke volume is a function of δL. Ventricular end-diastolic pressure is a function of resting muscle length. As increments of resting muscle length increased δL, increasing ventricular end-diastolic pressure augmented stroke volume. Increasing the load carried by the muscle (afterload) at a given resting muscle length increased work performed by the papillary muscle. Similarly, increasing aortic pressure increased stroke work for a given ventricular end-diastolic pressure in the intact heart. In the papillary muscle time to maximal δL was an inverse function of maximal velocity of shortening (Vmax), but independent of both Lr and afterload. The inverse relation of time to max δL and Vmax were shown for norepinephrine and frequency. In the intact heart time to peak ventricular pressure, was found to be largely independent of ventricular end-diastolic and aortic pressures and inversely related to the inotropic state of the myocardium. Contractility of the papillary muscle strictly defined by Vmax and Po, was thus characterized by time to maximal δL, as well as δL. Contractility of the ventricle at a given ventricular end-diastolic pressure could then be defined by stroke volume and peak pressure time, which are indices of force and velocity.

scholarly journals Aberrant Cardiac Muscle Mechanics in a Hypertrophic Cardiomyopathy Troponin T ILE79ASN Transgenic Mouse

2018 ◽  
Vol 114 (3) ◽  
pp. 502a
Author(s):  
Karissa M. Dieseldorff Jones ◽  
David Gonzalez-Martinez ◽  
Maicon Landim-Vieira ◽  
Yeojung Koh ◽  
Bjorn C. Knollmann ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Cardiac Muscle ◽  
Transgenic Mouse ◽  
Troponin T ◽  
Muscle Mechanics ◽  
Cardiac Muscle Mechanics

scholarly journals A novel method to study contraction characteristics of a single cardiac myocyte using carbon fibers

2001 ◽  
Vol 281 (3) ◽  
pp. H1442-H1446 ◽  
Author(s):  
So-Ichiro Yasuda ◽  
Seiryo Sugiura ◽  
Naoshi Kobayakawa ◽  
Hideo Fujita ◽  
Hiroshi Yamashita ◽  
...  
Keyword(s):  
Carbon Fiber ◽  
Cardiac Muscle ◽  
Carbon Fibers ◽  
Cardiac Myocyte ◽  
Muscle Mechanics ◽  
Experimental Apparatus ◽  
Muscle Research ◽  
Graphite Fibers ◽  
Cardiac Muscle Mechanics ◽  
Novel Method

To facilitate cardiac muscle research, we developed a novel method by which the force and length of a single ventricular myocyte can be recorded with a pair of carbon graphite fibers attached firmly to both ends. One fiber was stiff, whereas the other fiber was compliant to allow the recording of force and shortening during twitch contractions. The image of the compliant carbon fiber was projected onto a pair of photodiodes, and their output was fed to a piezoelectric transducer after variable amplifications to alter the effective compliance of the carbon fiber. Thus contraction of the myocyte was induced under virtually isometric conditions as well as under auxotonic conditions. We obtained a bell-shaped relation between the compliance under an auxotonic load and the work output of the myocyte, which was directly related to myocyte performance in the heart. Because it is easy to attach myocytes to the experimental apparatus, the present method would allow us to study cardiac muscle mechanics at the cellular and molecular levels.

Cardiac Muscle Mechanics

2018 ◽  
pp. 91-99
Author(s):  
Nicolaas Westerhof ◽  
Nikolaos Stergiopulos ◽  
Mark I. M. Noble ◽  
Berend E. Westerhof
Keyword(s):  
Cardiac Muscle ◽  
Muscle Mechanics ◽  
Cardiac Muscle Mechanics
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