selectivity optimization
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scholarly journals Is Structure-Based Drug Design Ready for Selectivity Optimization?

2020 ◽  
Vol 60 (12) ◽  
pp. 6211-6227
Author(s):  
Steven K. Albanese ◽  
John D. Chodera ◽  
Andrea Volkamer ◽  
Simon Keng ◽  
Robert Abel ◽  
...  
Keyword(s):  
Drug Design ◽  
Structure Based Drug Design ◽  
Selectivity Optimization

Potency and Selectivity Optimization of Tryptophanol‐Derived Oxazoloisoindolinones: Novel p53 Activators in Human Colorectal Cancer

ChemMedChem ◽  
2020 ◽  
Author(s):  
Valentina Barcherini ◽  
Joana Almeida ◽  
Elizabeth A. Lopes ◽  
Mi Wang ◽  
Diogo Magalhães e Silva ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Human Colorectal Cancer ◽  
Selectivity Optimization

Abstract 740: Phenotypic profiling and selectivity optimization of ERK inhibitors using a high-throughput imaged-based cell cycle assay

2014 ◽  
Author(s):  
Grace Ka-Yan Chan ◽  
Tracy Kleinheinz ◽  
Matthew Martinson ◽  
Hok-Sum Cheung ◽  
John G. Moffat
Keyword(s):  
Cell Cycle ◽  
High Throughput ◽  
Selectivity Optimization

Structure-Based Selectivity Optimization of Piperidine–Pteridine Derivatives as Potent Leishmania Pteridine Reductase Inhibitors

2012 ◽  
Vol 55 (19) ◽  
pp. 8318-8329 ◽  
Author(s):  
Paola Corona ◽  
Federica Gibellini ◽  
Andrea Cavalli ◽  
Puneet Saxena ◽  
Antonio Carta ◽  
...  
Keyword(s):  
Reductase Inhibitors ◽  
Selectivity Optimization ◽  
Pteridine Derivatives

Selectivity optimization in green chromatography by gradient stationary phase optimized selectivity liquid chromatography

2010 ◽  
Vol 1217 (46) ◽  
pp. 7222-7230 ◽  
Author(s):  
Kai Chen ◽  
Frédéric Lynen ◽  
Maarten De Beer ◽  
Laure Hitzel ◽  
Paul Ferguson ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Stationary Phase ◽  
Selectivity Optimization ◽  
Green Chromatography

ChemInform Abstract: Novel Bicyclic Lactam Inhibitors of Thrombin: Potency and Selectivity Optimization Through P1 Residues.

ChemInform ◽  
2010 ◽  
Vol 33 (10) ◽  
pp. no-no
Author(s):  
Sophie Levesque ◽  
Yves St-Denis ◽  
Benoit Bachand ◽  
Patrice Preville ◽  
Lorraine Leblond ◽  
...  
Keyword(s):  
Selectivity Optimization
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