Evolutionary Affinity and Selectivity Optimization of a Pesticide-Selective Antibody Utilizing a Hapten-Selective Immunoglobulin Repertoire

2002 ◽  
Vol 36 (22) ◽  
pp. 4892-4898 ◽  
Author(s):  
Karl Kramer
Keyword(s):  
Selectivity Optimization ◽  
Immunoglobulin Repertoire

scholarly journals Is Structure-Based Drug Design Ready for Selectivity Optimization?

2020 ◽  
Vol 60 (12) ◽  
pp. 6211-6227
Author(s):  
Steven K. Albanese ◽  
John D. Chodera ◽  
Andrea Volkamer ◽  
Simon Keng ◽  
Robert Abel ◽  
...  
Keyword(s):  
Drug Design ◽  
Structure Based Drug Design ◽  
Selectivity Optimization

scholarly journals Dangerous Liaisons: Gammaherpesvirus Subversion of the Immunoglobulin Repertoire

Viruses ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 788
Author(s):  
Monika A. Zelazowska ◽  
Kevin McBride ◽  
Laurie T. Krug
Keyword(s):  
B Cells ◽  
Somatic Hypermutation ◽  
Adaptive Immune Response ◽  
Kaposi Sarcoma ◽  
Lymphoid Tissues ◽  
Barr Virus ◽  
Sequencing Technologies ◽  
Biologic Property ◽  
Epstein Barr ◽  
Immunoglobulin Repertoire

A common biologic property of the gammaherpesviruses Epstein–Barr Virus and Kaposi sarcoma herpesvirus is their use of B lymphocytes as a reservoir of latency in healthy individuals that can undergo oncogenic transformation later in life. Gammaherpesviruses (GHVs) employ an impressive arsenal of proteins and non-coding RNAs to reprogram lymphocytes for proliferative expansion. Within lymphoid tissues, the germinal center (GC) reaction is a hub of B cell proliferation and death. The goal of a GC is to generate and then select for a pool of immunoglobulin (Ig) genes that will provide a protective humoral adaptive immune response. B cells infected with GHVs are detected in GCs and bear the hallmark signatures of the mutagenic processes of somatic hypermutation and isotype class switching of the Ig genes. However, data also supports extrafollicular B cells as a reservoir engaged by GHVs. Next-generation sequencing technologies provide unprecedented detail of the Ig sequence that informs the natural history of infection at the single cell level. Here, we review recent reports from human and murine GHV systems that identify striking differences in the immunoglobulin repertoire of infected B cells compared to their uninfected counterparts. Implications for virus biology, GHV-associated cancers, and host immune dysfunction will be discussed.

A single diversified VH gene family dominates the bovine immunoglobulin repertoire

1997 ◽  
Vol 25 (2) ◽  
pp. 326S-326S ◽  
Author(s):  
ROBERT AITKEN ◽  
JANICE GILCHRIST ◽  
M. CATHERINE SINCLAIR
Keyword(s):  
Gene Family ◽  
Vh Gene ◽  
Immunoglobulin Repertoire ◽  
Bovine Immunoglobulin

Characterization of the immunoglobulin repertoire of the spiny dogfish (Squalus acanthias)

2012 ◽  
Vol 36 (4) ◽  
pp. 665-679 ◽  
Author(s):  
Lauren E. Smith ◽  
Kathryn Crouch ◽  
Wei Cao ◽  
Mischa R. Müller ◽  
Leeying Wu ◽  
...  
Keyword(s):  
Squalus Acanthias ◽  
Spiny Dogfish ◽  
Immunoglobulin Repertoire

scholarly journals E2A and EBF Act in Synergy with the V(D)J Recombinase to Generate a Diverse Immunoglobulin Repertoire in Nonlymphoid Cells

2000 ◽  
Vol 5 (2) ◽  
pp. 343-353 ◽  
Author(s):  
William J Romanow ◽  
Anton W Langerak ◽  
Peter Goebel ◽  
Ingrid L.M Wolvers-Tettero ◽  
Jacques J.M van Dongen ◽  
...  
Keyword(s):  
Immunoglobulin Repertoire

Abstract 740: Phenotypic profiling and selectivity optimization of ERK inhibitors using a high-throughput imaged-based cell cycle assay

2014 ◽  
Author(s):  
Grace Ka-Yan Chan ◽  
Tracy Kleinheinz ◽  
Matthew Martinson ◽  
Hok-Sum Cheung ◽  
John G. Moffat
Keyword(s):  
Cell Cycle ◽  
High Throughput ◽  
Selectivity Optimization

A comprehensive analysis of germline and expressed immunoglobulin repertoire in the horse

2010 ◽  
Vol 34 (9) ◽  
pp. 1009-1020 ◽  
Author(s):  
Yi Sun ◽  
Chunyan Wang ◽  
Yating Wang ◽  
Tianyi Zhang ◽  
Liming Ren ◽  
...  
Keyword(s):  
Comprehensive Analysis ◽  
Immunoglobulin Repertoire
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