Tte temporary organization of hemostasis system and microcirculation rhythms while gestational DIC-syndrome against the background of phytocorrection while the experiment

The state of temporal organization of hemostasis system (HS) and microcirculation (MC) was studied in 72 rats of Wistar line weighted 200-250 gr. They were in 8 groups: intact rats, rats with physiologic pregnancy; with experimental gestosis; prophylactic and treatment-and-prophylactic injections of complex phytoadaptogens – phytococktails “Biorhythm-E” and “Biorhythm-RG”. The analysis of coagulation and microcirculation indices was performed on the 21-st day of gestation. The biorhythms were estimated with the help of “cosinor-analysis” programmer. The reliable ultradian biorhythms prevailed in the intact rats, among which there were rhythms (5%) with high and middle amplitude, with the period of 5-7 hours. The chronic intersystemic pathologic desynchronosis developed while the experimental gestosis. The usage of phytococktail “Biorhythm-E” was more effective while the architectonics of temporal organization impairment at the expense of the part of the reliable circadian rhythms increase while the treatment-and-prophylactic administration. The usage of complex phytoadaptogens promoted the increase of HS and MC adaptation resources, normalizing the impaired architectonics of biological rhythms.

Change of indicators of a hemostasis at females with experimental gestosis under the influence of gaba derivatives

It is shown that in the conditions of experimental gestosis, induced by replacing drinking water of 1.8% sodium chloride at rats from the first day of gestation until birth, observes disturbances of coagulative properties and augmentation of thrombogenic potential of a blood to what shorting APTT, prothrombin and thrombin time, rising of level of a fibrinogen, hyperaggregation of thrombocytes testifies. GABA-derivative compounds WPC-147, WPC-189 and comparator drug sulodexide show anticoagulant and antiplatelet activity in the conditions of experimental gestosis, extending APTT, thrombin and a prothrombin time, reducing fibrinogen level, reducing platelet aggregation