Tte temporary organization of hemostasis system and microcirculation rhythms while gestational DIC-syndrome against the background of phytocorrection while the experiment

2014 ◽  
Vol 20 (29) ◽  
pp. 0-0
Author(s):  
Датиева ◽  
Fatima Datieva ◽  
Хетагурова ◽  
Larisa Khetagurova
Keyword(s):  
Circadian Rhythms ◽  
Biological Rhythms ◽  
The State ◽  
Temporal Organization ◽  
Cosinor Analysis ◽  
Hemostasis System ◽  
Prophylactic Administration ◽  
Experimental Gestosis ◽  
Intact Rats

The state of temporal organization of hemostasis system (HS) and microcirculation (MC) was studied in 72 rats of Wistar line weighted 200-250 gr. They were in 8 groups: intact rats, rats with physiologic pregnancy; with experimental gestosis; prophylactic and treatment-and-prophylactic injections of complex phytoadaptogens – phytococktails “Biorhythm-E” and “Biorhythm-RG”. The analysis of coagulation and microcirculation indices was performed on the 21-st day of gestation. The biorhythms were estimated with the help of “cosinor-analysis” programmer. The reliable ultradian biorhythms prevailed in the intact rats, among which there were rhythms (5%) with high and middle amplitude, with the period of 5-7 hours. The chronic intersystemic pathologic desynchronosis developed while the experimental gestosis. The usage of phytococktail “Biorhythm-E” was more effective while the architectonics of temporal organization impairment at the expense of the part of the reliable circadian rhythms increase while the treatment-and-prophylactic administration. The usage of complex phytoadaptogens promoted the increase of HS and MC adaptation resources, normalizing the impaired architectonics of biological rhythms.

scholarly journals Understanding Quantitative Circadian Regulations Are Crucial Towards Advancing Chronotherapy

Cells ◽  
2019 ◽  
Vol 8 (8) ◽  
pp. 883 ◽  
Author(s):  
Debajyoti Chowdhury ◽  
Chao Wang ◽  
Ai-Ping Lu ◽  
Hai-Long Zhu
Keyword(s):  
Circadian Rhythms ◽  
Molecular Mechanisms ◽  
Temporal Stability ◽  
Biological Rhythms ◽  
Integrative Approach ◽  
Peripheral Tissues ◽  
Innovative Strategies ◽  
Neural Connections ◽  
Core Components ◽  
The Brain

Circadian rhythms have a deep impact on most aspects of physiology. In most organisms, especially mammals, the biological rhythms are maintained by the indigenous circadian clockwork around geophysical time (~24-h). These rhythms originate inside cells. Several core components are interconnected through transcriptional/translational feedback loops to generate molecular oscillations. They are tightly controlled over time. Also, they exert temporal controls over many fundamental physiological activities. This helps in coordinating the body’s internal time with the external environments. The mammalian circadian clockwork is composed of a hierarchy of oscillators, which play roles at molecular, cellular, and higher levels. The master oscillation has been found to be developed at the hypothalamic suprachiasmatic nucleus in the brain. It acts as the core pacemaker and drives the transmission of the oscillation signals. These signals are distributed across different peripheral tissues through humoral and neural connections. The synchronization among the master oscillator and tissue-specific oscillators offer overall temporal stability to mammals. Recent technological advancements help us to study the circadian rhythms at dynamic scale and systems level. Here, we outline the current understanding of circadian clockwork in terms of molecular mechanisms and interdisciplinary concepts. We have also focused on the importance of the integrative approach to decode several crucial intricacies. This review indicates the emergence of such a comprehensive approach. It will essentially accelerate the circadian research with more innovative strategies, such as developing evidence-based chronotherapeutics to restore de-synchronized circadian rhythms.

Circadian rhythms of acid and bicarbonate efflux in fasting rat stomach

1991 ◽  
Vol 260 (4) ◽  
pp. G610-G614 ◽  
Author(s):  
K. R. Larsen ◽  
J. G. Moore ◽  
M. T. Dayton
Keyword(s):  
Circadian Rhythms ◽  
Test Solution ◽  
Circadian Rhythmicity ◽  
Sprague Dawley ◽  
Rat Stomach ◽  
Cosinor Analysis ◽  
Sprague Dawley Rats ◽  
Gastric Lumen ◽  
Sampling Times ◽  
Fasted Rats

One model of gastric ulcerogenesis implicates a disruption of complementary circadian rhythms between protective and destructive factors. The purpose of this study was to compare circadian rhythms in gastric production of H+ and HCO3- in fasted rats. Sprague-Dawley rats were acclimatized in sound-attenuating, light-proof chambers for 3 wk on a 12:12-h light-dark schedule. Eighteen-hour fasted rats were studied at each of eight sampling times. After anesthesia, the stomachs were cannulated and filled with test solution. Thirty-minute gastric samples were titrated for H+ or assayed for HCO3-. Cosinor analysis of the data showed significant (P less than 0.05) circadian rhythms for both H+ and HCO3-. Peak times were 22:45 HALO (hours after lights on) (4:45 A.M.) for H+ and 05:41 HALO (11:41 A.M.) for HCO3-. These data demonstrate that H+ and HCO3- secretion in the fasting rat gastric lumen follow circadian rhythms with different peak times. Theoretically, this may result in circadian rhythmicity of relative mucosal vulnerability to injury.

scholarly journals Genetic variation and phenotypic plasticity in circadian rhythms in an armed beetle, Gnatocerus cornutus (Tenebrionidae)

2020 ◽  
Vol 130 (1) ◽  
pp. 34-40 ◽  
Author(s):  
Kentarou Matsumura ◽  
Masato S Abe ◽  
Manmohan D Sharma ◽  
David J Hosken ◽  
Taishi Yoshii ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Phenotypic Plasticity ◽  
Circadian Rhythms ◽  
Temperature Effects ◽  
Temperature Compensation ◽  
Biological Rhythms ◽  
Total Activity ◽  
Biological Clocks ◽  
Isofemale Lines ◽  
Free Running

Abstract Circadian rhythms, their free-running periods and the power of the rhythms are often used as indicators of biological clocks, and there is evidence that the free-running periods of circadian rhythms are not affected by environmental factors, such as temperature. However, there are few studies of environmental effects on the power of the rhythms, and it is not clear whether temperature compensation is universal. Additionally, genetic variation and phenotypic plasticity in biological clocks are important for understanding the evolution of biological rhythms, but genetic and plastic effects are rarely investigated. Here, we used 18 isofemale lines (genotypes) of Gnatocerus cornutus to assess rhythms of locomotor activity, while also testing for temperature effects. We found that total activity and the power of the circadian rhythm were affected by interactions between sex and genotype or between sex, genotype and temperature. The males tended to be more active and showed greater increases in activity, but this effect varied across both genotypes and temperatures. The period of activity varied only by genotype and was thus independent of temperature. The complicated genotype–sex–environment interactions we recorded stress the importance of investigating circadian activity in more integrated ways.

Internal synchronization among several circadian rhythms in rats under constant light

1978 ◽  
Vol 235 (5) ◽  
pp. R243-R249 ◽  
Author(s):  
K. I. Honma ◽  
T. Hiroshige
Keyword(s):  
Locomotor Activity ◽  
Body Temperature ◽  
Circadian Rhythms ◽  
Continuous Light ◽  
Biological Rhythms ◽  
Plasma Corticosterone ◽  
Dark Cycle ◽  
Internal Oscillator ◽  
Free Running ◽  
Phase Angles

Three biological rhythms (locomotor activity, body temperature, and plasma corticosterone) were measured simultaneously in individual rats under light-dark cycles and continuous light. Spontaneous locomotor activity was recorded on an Animex and body temperature was telemetrically monitored throughout the experiments. Blood samples were obtained serially at 2-h intervals on the experimental days. Phase angles of these rhythms were calculated by a least-squares spectrum analysis. Under light-dark cycles, the acrophases of locomotor activity, body temperature, and plasma corticosterone were found at 0029, 0106, and 1940 h, respectively. When rats were exposed to 200 lx continuous light, locomotor activity and body temperature showed free-running rhythms with a period of 25.2 h on the average. Plasma corticosterone levels determined at 12 days after exposure to continuous light exhibited a circadian rhythm with the acrophase shifted to 0720. The acrophases of locomotor activity and body temperature, determined simultaneously on the same day, were found to be located at 1303 and 1358 h, respectively. Phase-angle differences among the three rhythms on the 12th day of continuous light were essentially the same with those under the light-dark cycle. These results suggest that circadian rhythms of locomotor activity, body temperature, and plasma corticosterone are most probably coupled to a common internal oscillator in the rat.

scholarly journals Circadian Clock and The Cardiometabolic Risk

2010 ◽  
Vol 2 (2) ◽  
pp. 16
Author(s):  
Anna Meiliana ◽  
Andi Wijaya
Keyword(s):  
Circadian Rhythms ◽  
Cardiometabolic Risk ◽  
Clock Genes ◽  
Epidemiological Data ◽  
Circadian System ◽  
Temporal Organization ◽  
Liver Fat ◽  
Peripheral Tissues ◽  
The Central Nervous System ◽  
Rotation Of The Earth

BACKGROUND: Epidemiological data reveal parallel trends of decreasing sleep duration and increases in metabolic disorders such as obesity, diabetes and hypertension. There is growing evidence that these trends are mechanistically related.CONTENT: The circadian system orchestrates the temporal organization of many aspects of physiology, including metabolism, in synchrony with the 24 hours rotation of the Earth. The circadian system is a complex feedback network that involves interactions between the central nervous system and peripheral tissues. Circadian regulation is intimately linked to metabolic homeostasis and that dysregulation of circadian rhythms can contribute to disease. Conversely, metabolic signals also feed back into the circadian system, modulating circadian gene expression and behavior.SUMMARY: Both inter- and intraorgan desynchrony may be involved in the pathogenesis of cardiometabolic disease attributable to effects in brain and multiple metabolic tissues including heart, liver, fat, muscle, pancreas and gut. Efforts to dissect the molecular mediators that coordinate circadian, metabolic, and cardiovascular systems may ultimately lead to both improved therapeutics and preventive interventions.KEYWORDS: circadian rhythms, clock genes, nuclear receptor, sleep, obesity, cardiometabolic risk

scholarly journals Using a coupled-oscillator model of speech rhythm to estimate rhythmic variability in two Brazilian Portuguese varieties (CE and SP)

2021 ◽  
Vol 2 (4) ◽  
pp. e577
Author(s):  
Pablo Arantes ◽  
Ronaldo Mangueira Lima Júnior
Keyword(s):  
Brazilian Portuguese ◽  
The State ◽  
Temporal Organization ◽  
Hierarchical Regression ◽  
Entrainment Rate ◽  
Speech Rhythm ◽  
Bayesian Hierarchical ◽  
Syllable Duration ◽  
Natural Duration ◽  
Relative Change

This paper presents preliminary results of a semi-automatic methodology to extract three parameters of a dynamic model of speech rhythm. The model attempts to analyze the production of rhythm as a system of coupled oscillators which represent syllabicity and phrase stress as levels of temporal organization. The estimated parameters are the syllabic oscillator entrainment rate (alpha), the syllabic oscillator decay rate (beta), and the coupling strength between the oscillators (w0). The methodology involves finding the <alpha, beta, w0> combination that minimizes the distance between natural duration contours and simulated contours generated using several combinations of the parameters. The distance between natural and model-generated contours was measured in two ways by comparing: (1) plain or overt syllable to syllable duration and (2) relative change along both contours.We applied this methodology to read speech produced by five speakers of the state of Ceará (CE) and eight speakers of the state of São Paulo (SP). Mean w0 and alpha values are compatible with the view that Brazilian Portuguese is a mixed-rhythm language. Results from two bayesian hierarchical regression models do not suggest a difference between SP and CE speakers, but indicate a difference between the two methods, with the relative change method generating lower alpha values and higher w0 values, and the reverse for the plain duration method.

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