Features of functional maturation of the central nervous system in fetuses with multiple pregnancies

The study was undertaken to detect some peculiarities of fetal rest activity cycle formation in multiple pregnancy. 86 fetuses (43 twins) were observed with the following assessment of the newbornsneurological status. The rest activity cycle parameters and haemodynamic indices of fetoplacental system were examined. Also there was considered the influence of IUGR and twins birth weight discordance on CNSfunctionalformation. The results showed that twins comparing with single pregnancies are characterized by the retardation of rest activity cycle formation that is manifested in shortening оf the quite and prolongation оf the intermediate states, lowering of cardiac rhythm variability and motorcardial reflex. These findings substantiate the necessity of including twins into high-risk group concerning neurological disorders in the newborns. The IUGR appears an additional factor increasing this risk.

Analysis of cardiac rhythm variability in Jersey breed cows with different vegetative status

Purpose: Conduct an analysis of cardiac rhythm variability in the cows of the Jersey breed with a different vegetative status.Materials and methods. Indicators of the electrocardiogram (ECG) and cardiac rhythm variability studied on cows of the Jersey breed (n = 103). For the analysis and removal of ECG, the animal studied used the program «Conan-4.5» in the system of frontal administrations according to the method of P. M. Roshchensky. Clinical research methods were carried out according to the methods of clinical inspection of animals B. V. Ears and included — inspection, palpation, percussion and auscultation of the heart area.Results. Among the entire studied array of animals, the largest amount was sympathyone — 50,5%, normotonics — 24,3%, hypersympathicotonics — 16,5%. The smallest amount — vagotonic — 8,7%. For the vagotonic, the respiratory modulation index was 8,16±0,02%, the index of the sympathetic system is 43±0,1%, and the index of slowly wave arrhythmia is 0,8±0,1%. This group of cows parasympathetic (software) prevails over the sympathetic department of the vegetative nervous system. For normotonics, the value of the respiratory modulation index was 4,14±0,03%, the index of the sympathetic system is 96±0,2%, and im is 2,5±0,2%. This group is characterized by an equilibrium state between sympathetic department and VNS. The ids for sympathicotonists amounted to 2,78±0,03%, the index of the sympathetic system is 195±0,2%, and im is 8,2±0,1%. At sympathicotonists, which are characterized by a predominance with VNS above software. The hyper smpathetical respiratory modulation index was 1,34±0,02%, ICAS — 588±0,1%, and im is 11,4±0,3%. In hypersympathicotonists, which are characterized by the predominance of the super-viper vehicle of the vegetative nervous system over parasympathetic.Conclusion. The separation of the entire array on the subgroups based on the vegetative status of animals was based on the indicators of the voltage index of regulatory systems. To confirm the correctness of the separation of the studied array of animals on the subgroup, statistical processing was carried out and a classification matrix was built. Also, to confirm the classification separation matrix, additional statistical processing of the material of the differences between the obtained groups in the square of the distance of the Mahalonobis D2 was carried out. In the course of further registration and mathematical analysis of the variability of the heart rate of cattle (cows of the Jersey breed) with the help of a modern complex electrophysiological laboratory «Conan-4.5» features of indexes of A. Ya. Kaplan were established.

ПОРУШЕННЯ ВАРІАБЕЛЬНОСТІ СЕРЦЕВОГО РИТМУ ЯК МЕТОД ОЦІНЮВАННЯ АДАПТАЦІЙНИХ РЕАКЦІЙ ОРГАНІЗМУ ВАГІТНИХ ПРИ НАЯВНОСТІ ШКІДЛИВИХ ЗВИЧОК

According to modern data, the cardiovascular system is a kind of indicator of the organism's adaptive activity, and the structure of the heart rhythm carries information about the development of adaptive reactions in response to irritating factors of the external and internal environment.The aim of the study – to investigate the functional state of the autonomic nervous system in pregnant women who have harmful habits by evaluating and analyzing the parameters of heart rate variability in order to prevent complications of non-delivery of gestational process.Materials and Methods. The study involved 73 pregnant women, 53 of them were pregnant (the main group) who had malignant habits in history. Before studying adaptive reactions in pregnant women, a study of cardiac rhythm variability was performed in practically healthy non-pregnant women of reproductive age (25.3±2.2) years). The control group consisted of 20 pregnant women without any harmful habits. Determination of heart rate variability was performed on the basis of peripheral heart rate recording, which included measuring the sequence of RR intervals for 5 minutes, followed by mathematical analysis using the PlsMntr software product.Results and Discussion. It was established that in the main group, in the complicated failure to pass the gestational process, violations of cardiac rhythm variability were detected in 59.7 % of cases. There is an increase in the frequency of very low frequency (VL F) waves (43.5 % relative to control, p<0.05), indicating a predominance of humoral and metabolic rate of regulation of the cardiac rhythm. At the threat of premature births, a decrease in the particle (LF) is observed at 36.6 %, a decrease in the share of high-frequency waves (НF) by 30.8 %. Taking into account the results of the study, one can speak of a decrease in the tone of the sympathetic and parasympathetic nervous system, reducing the influence of the reflexive vegetative level of regulation, which, in turn, indicates the depletion of regulatory mechanisms and the lack of an adaptive protective effect of n.vagus on the heart.Conclusions. Our innovative low-invasive method of evaluating the adaptive reactions of the organism through the determination and analysis of indicators of cardiac rhythm variability in pregnant women with the existing harmful habits offers us the opportunity to observe manifestations of functional stress of regulatory systems of pregnant women, preceding the development of complication of non-delivery of gestational process.

VEGETATIVE BALANCE AND VARIABILITY OF HEART RHYTHM IN STUDENTS OF GENERAL EDUCATIONAL INSTITUTIONS IN CONDITIONS OF THE MULTICOMPONENT INFLUENCE OF FACTORS OF THE ENVIRONMENT

The establishment of the features of the change in the indices of the functional state of the organism under the influence of the multifactorial environment of children is a complex process since the level of any system is supported by a number of compensatory mechanisms, based on the multiparametric interaction of organs and body systems. In this regard, the search for a “weak link”, which, first of all, undergoes changes in the system of regulatory processes for maintaining homeostasis, is topical. The analysis of data on the variability of cardiac rhythm in children aged 7-10 years exposed to complex effects of intraschool environment factors in accordance with a comprehensive assessment of the learning and upbringing conditions within 670-679.5 points and environmental factors, the total anthropogenic load factor of which was within 10.5 -25.8 units revealed no specific changes in statistical indices of the cardiac rhythm variability due to the inclusion of a complex of compensatory mechanisms, which are the basis for multiparametric interaction of the body’s functional systems aimed at maintaining a certain level of functioning of the cardiovascular system, sufficient to adapt to changing environmental conditions a habitat. The established signs of the autonomic dysfunction in children aged 7-10 years in conditions of the comprehensive influence of the factors of the educational process, learning conditions and the environment can testify to the development of disadaptive reactions in the organism of the schoolchildren under study