HEART RATE VARIABILITY AS A REFLECTION OF THE TONE OF THE VEGETATIVE NERVOUS SYSTEM OF SURGERY OF TUMORS OF THE REPRODUCTIVE SYSTEM OF WOMEN

The article presents the results of a study of heart rate variability at women after hysterectomy with appendages. There were showed the relationship of the sympathetic and parasympathetic system in the regulation of the heart rhythm.

Biorhythmostimulation in complex treatment of patients with initial forms of brain blood supply insufficiency

Study of biorhythmostimulation efficiency in complex treatment of patients with initial forms of brain blood supply insufficiency was carried out. The obtained results are indicative of high efficiency of the given method of psychoemotional condition of patients. True reliable normalisation of arterial pressure, brain vascular tension, vegetative nervous system, cerebral cortex electrical activity took place. Biorhythmostimulatuion is a highly effective and pathogenically substantiated method of psychoemotional condition correction and can be widely used with medical purposes for patients with initial forms of brain blood supply insufficiency.

Vegetative Indices in Assessing Effectiveness of the Photobioacoustic Complex in Children with the Vegetative Nervous System Somatoform Dysfunction, often Suffering from Acute Recurrent Infections

Photobioacoustic methods of complex exposure allow correcting vegetative, vascular-cardiac disorders in children with autonomicnervous system somatoform dysfunction syndrome (ANSSDS) without pharmacological load. Aim. To optimize the treatment of children with somatoform vegetative dysfunction (ANSSDS), often suffering from recurrent infections,using physiotherapy methods.The aim of the study was to optimize the treatment of children with somatoform vegetativedysfunction, often suffering from recurrentinfections, using physiotherapy methods. Material and methods. The study included 140 children with autonomic nervous system somatoform dysfunction syndrome (ANSSDS),often suffering from recurrent infection. For the first time, clinical complaints, functional (ECG and cardiointerval recording KIR)and vegetative indicators (Kerdo, Hildebrandt index, Biend, Baoev-Parin) before/after application of the innovative photobioacousticcomplex, including: BАС-BFB-bioacoustic effects on the head and LLLR on the projection of the cubital region and thymus were analyzed.The duration of the procedure was 30 minutes and the course of treatment was 10 procedures. Before and after the procedures,vegetative indices and indicators of myocardial bioelectrogenesis were examined, comparing them with the norm in healthy children. Results. 35% of children were diagnosed with parasympathicotonia (sympathetic imbalance -SI); 54.1% – sympathetic (SA) and10.9% – mixed (etonia – E) type of vegetative dystonia. There were reveled gender-age differences in subjective complaints of childrenwith ANSSDS, whose index vegetative indicators were correlated with the type of vegetative support. Children with SA were 2.5 timesmore likely to be diagnosed with cardiac syndrome and elevated blood pressure; in children with SI – 3.5 times more often detected:gastric, astheenoeurotic syndrome and allergic diseases; in children with E: asthenonevrotic, neurosis-like disorders and sleep disturbancesthat were differentiated after the use of photobioacoustic complex. Complaints and vegetative indices in children with SI andE were corrected more significantly than in SA. Conclusion. Evaluation of vegetative indicators in children 7-12 years with ANSSDS, often suffering from recurrent infection, allows topersonify treatment programs and reduce the level of acute recurrent morbidity by 2.5 times.

COMPREHENSIVE ASSESSMENT OF RISK FACTORS FOR AUTONOMIC DYSFUNCTIONS IN SCHOOLCHILDREN AND THE POSSIBILITIES OF THEIR MANAGEMENT

The literature review is concerned with the analysis of current studies on the disorders of the autonomic nervous system in childhood. Autonomic dysfunction syndrome (ADS) occurs in the general child populaton in more than 20% of cases, and in some children may cause the development of many somatic diseases. Recently, there has been a tendency toward the increase in the number of children with manifestations of this pathology. This may be explained by the ambiguousness of the methodological approach, taking into account either all or markedly pronounced disorders only. The prevalence of vegetative dysfunction is obvious, even among people who consider themselves to be apparently healthy. Moreover, there are no such pathological conditions the development and course of which do not involve vegetative mechanisms. Primary dysfunction of the autonomic nervous system initially causes functional disorders, particularly those of the cardiovascular system. In fact, arterial hypertension and hypotension are the basis for the development of such serious diseases of adults as coronary heart disease and hypertension leading to the development of serious complications. The symptoms of vegetative-vascular dystonia are associated with the dysfunction and coordinated interaction of the two parts of the autonomic nervous system, rather than the pathology of any internal organ. It is important not to miss the patient’s subjective complaints related to the functioning of various organs which simulate the disease, but in fact no pathology is detected, as the clinical symptoms are associated with the imbalance of the nervous system. In case of any autonomic disturbance, the etiology and nature of the disorder should be clarified; the level of involvement of the autonomic nervous system, brain structures, parasympathetic and sympathetic autonomic formations must be determined. As reported by the publications, psycho-emotional factors are among the main reasons that contribute to ADS development, especially in senior schoolchildren. In most of them, vegetative lability in puberty is unstable, but with additional exposure and a combination of other causes it stabilizes. That is why, special attention should be paid to the factors affecting children’s psycho-emotional state, the phenomenon of “bullying behavior” (bullying). Well-known bullying researchers have studied the reationships between young people at school and have concluded that bullying behavior involves some negative actions leading to resentment and chronic stress. Some publications state that current stressful environment is a powerful trigger for nervous system dysfunction and can lead to negative consequences in adult life. The development of new approaches to the early diagnosis, treatment and prevention of this pathology in childhood is integral for reducing the incidence of the disease among adult population. Nowadays, the management of autonomic vegetative nervous system dysfunction is significantly difficult. Vegetative stigmatization, which accompanies any pathological process, is routinely perceived as its obligatory component, inherent in both clinical symptoms of the disease and its pathogenesis. Therefore, due attention is not always paid to the management of autonomic disorders in somatic pathology. Treatment of vegetative disturbances is based on conventional regimens, which are mostly ineffective; it is obvious that proper diagnosis and successful treatment requires individual approach to each patient.

Analysis of cardiac rhythm variability in Jersey breed cows with different vegetative status

Purpose: Conduct an analysis of cardiac rhythm variability in the cows of the Jersey breed with a different vegetative status.Materials and methods. Indicators of the electrocardiogram (ECG) and cardiac rhythm variability studied on cows of the Jersey breed (n = 103). For the analysis and removal of ECG, the animal studied used the program «Conan-4.5» in the system of frontal administrations according to the method of P. M. Roshchensky. Clinical research methods were carried out according to the methods of clinical inspection of animals B. V. Ears and included — inspection, palpation, percussion and auscultation of the heart area.Results. Among the entire studied array of animals, the largest amount was sympathyone — 50,5%, normotonics — 24,3%, hypersympathicotonics — 16,5%. The smallest amount — vagotonic — 8,7%. For the vagotonic, the respiratory modulation index was 8,16±0,02%, the index of the sympathetic system is 43±0,1%, and the index of slowly wave arrhythmia is 0,8±0,1%. This group of cows parasympathetic (software) prevails over the sympathetic department of the vegetative nervous system. For normotonics, the value of the respiratory modulation index was 4,14±0,03%, the index of the sympathetic system is 96±0,2%, and im is 2,5±0,2%. This group is characterized by an equilibrium state between sympathetic department and VNS. The ids for sympathicotonists amounted to 2,78±0,03%, the index of the sympathetic system is 195±0,2%, and im is 8,2±0,1%. At sympathicotonists, which are characterized by a predominance with VNS above software. The hyper smpathetical respiratory modulation index was 1,34±0,02%, ICAS — 588±0,1%, and im is 11,4±0,3%. In hypersympathicotonists, which are characterized by the predominance of the super-viper vehicle of the vegetative nervous system over parasympathetic.Conclusion. The separation of the entire array on the subgroups based on the vegetative status of animals was based on the indicators of the voltage index of regulatory systems. To confirm the correctness of the separation of the studied array of animals on the subgroup, statistical processing was carried out and a classification matrix was built. Also, to confirm the classification separation matrix, additional statistical processing of the material of the differences between the obtained groups in the square of the distance of the Mahalonobis D2 was carried out. In the course of further registration and mathematical analysis of the variability of the heart rate of cattle (cows of the Jersey breed) with the help of a modern complex electrophysiological laboratory «Conan-4.5» features of indexes of A. Ya. Kaplan were established.

Partial Agonist Activity of Neonicotinoids on Rat Nicotinic Receptors: Consequences over Epinephrine Secretion and In Vivo Blood Pressure

Neonicotinoid insecticides are nicotine-derived molecules which exert acute neurotoxic effects over the insect central nervous system by activating nicotinic acetylcholine receptors (nAChRs). However, these receptors are also present in the mammalian central and peripheral nervous system, where the effects of neonicotinoids are faintly known. In mammals, cholinergic synapses are crucial for the control of vascular tone, blood pressure and skeletal muscle contraction. We therefore hypothesized that neonicotinoids could affect cholinergic networks in mammals and sought to highlight functional consequences of acute intoxication in rats with sub-lethal concentrations of the highly used acetamiprid (ACE) and clothianidin (CLO). In this view, we characterized their electrophysiological effects on rat α3β4 nAChRs, knowing that it is predominantly expressed in ganglia of the vegetative nervous system and the adrenal medulla, which initiates catecholamine secretion. Both molecules exhibited a weak agonist effect on α3β4 receptors. Accordingly, their influence on epinephrine secretion from rat adrenal glands was also weak at 100 M, but it was stronger at 500 M. Challenging ACE or CLO together with nicotine (NIC) ended up with paradoxical effects on secretion. In addition, we measured the rat arterial blood pressure (ABP) in vivo by arterial catheterization. As expected, NIC induced a significant increase in ABP. ACE and CLO did not affect the ABP in the same conditions. However, simultaneous exposure of rats to both NIC and ACE/CLO promoted an increase of ABP and induced a biphasic response. Modeling the interaction of ACE or CLO on α3β4 nAChR is consistent with a binding site located in the agonist pocket of the receptor. We present a transversal experimental approach of mammal intoxication with neonicotinoids at different scales, including in vitro, ex vivo, in vivo and in silico. It paves the way of the acute and chronic toxicity for this class of insecticides on mammalian organisms

Duration of functional stability to non-specific aerobic load in wrestlers

Objective: study the duration of establishment of functional stability to non-specific stress in wrestlers.Materials and Methods. Nineteen athletes in martial arts, mid-age 23 ± 3 years of age, participated in the study. The qualification level of the subjects ranged from first sport grade to Master of Sport. A series of sports training was organized within 4 weeks. Each train consisted of a smooth-running load of 40 minutes at a speed corresponding to the anaerobic exchange threshold (AET). The indicators of the duration of reaching the AET level by heart rate (HR), the power of the low frequency and high frequency component of the spectrum were analyzed.Results. The effect of urgent adaptation, in the form of an extension of the duration the heart rate on the anaerobic threshold level from 29 to 32 mines and the increase in the regulation of vegetative nervous system by increasing the total power of the spectrum observed on the third day of the training cycle. From the third to ninth days of the study, fatigue occurs, as can be seen from the lowering of the anaerobic threshold time to 21 minutes, as well as the lowering of the high-frequency part of the vegetative nervous system regulatory spectrum. The emergency adaptation ends by 9 days of observation, after four high-intensity exercises, which manifests itself in stabilizing the regulation of the heart rate, vegetative nervous system goes from a reflex level to a lower one — a humeral metabolic level. The time to reach the HR in the aerobic threshold will stabilize at 21–23 minutes.Conclusions. Functional stability to the non-specific aerobic load in the wrestlers emerged by the twentyseventh day of the study after ten highly intensive aerobic exercises, which confirmed by the results of the time dynamics of the tine of HR in aerobic threshold and analysis of spectrum results of HRV.