infectious bronchitis virus infection
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2021 ◽  
Vol 7 ◽  
Author(s):  
Jun Kuang ◽  
Puzhi Xu ◽  
Yan Shi ◽  
Yitian Yang ◽  
Ping Liu ◽  
...  

Infectious bronchitis is a highly contagious, acute viral respiratory disease of chickens, regardless of the strain, and its infection may lead to considerable economic losses to the poultry industry. New nephropathogenic infectious bronchitis virus (NIBV) strains have increasingly emerged in recent years; hence, evaluating their infection-influenced immune function changes and the alteration of metabolite profiling is important. Initially, chickens were randomly distributed into two groups: the control group (Con) and the disease group (Dis). Here, the partial cytokines were examined, and the metabolome alterations of the bursa of Fabricius (BF) in NIBV infections in chickens were profiled by gas chromatography time-of-flight/mass spectrometry (GC-TOF/MS). The results revealed that the NIBV infection promotes the mRNA expression of inflammatory cytokines. Metabolic profile analysis indicated that clustering differed between the two groups and there were 75 significantly different metabolites detected between the two groups, suggesting that the host metabolism was significantly changed by NIBV infection. Notably, the following 12 metabolites were identified as the potential biomarkers: 3-phenyllactic acid, 2-deoxytetronic acid, aminomalonic acid, malonamide 5, uric acid, arachidonic acid, 2-methylglutaric acid, linoleic acid, ethanolamine, stearic acid, N-alpha-acetyl-l-ornithine, and O-acetylserine. Furthermore, the results of the correlation analysis showed that a strong correlation existed between metabolic biomarkers and inflammatory cytokines. Our results describe an immune and metabolic profile for the BF of chickens when infected with NIBV and provide new biomarkers of NIBV infection as potential targets and indicators of indicating therapeutic efficacy.


2020 ◽  
Vol 141 ◽  
pp. 103998 ◽  
Author(s):  
Hao Li ◽  
Jianan Li ◽  
Yaru Zhai ◽  
Lan Zhang ◽  
Pengfei Cui ◽  
...  

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Matilda Ayim-Akonor ◽  
Doreen Dela Owusu-Ntumy ◽  
Hilda Emefa Ohene-Asa ◽  
Agyekum Oduro-Abrokwa ◽  
Patricia Hammond ◽  
...  

Infectious bronchitis is an economically important disease with worldwide distribution. Information is available on the presence of infectious bronchitis virus in commercial chicken in parts of Ghana but there is no information on free-range poultry and guinea fowls in the country. Possible IBV infections among free-range chickens and guinea fowls in Abokobi and Frafraha communities in the Ga-East district of the Greater Accra Region of Ghana were investigated using serology and PCR. Blood, tracheal, and cloacal swabs were obtained from 219 free-range chickens and guinea fowls with no respiratory symptoms and no history of IBV vaccination. Sera were evaluated for IBV antibodies by ELISA using commercial IBV test kit from IDEXX, Inc., USA. Swab samples were evaluated for S1 glycoprotein gene by one-step RT PCR. All the swab samples tested negative for IBV. 16% of all tested sera were positive for IBV. IBV seroprevalence in guinea fowls was 0%. 21.2% of sera from local chickens were positive for IBV. The seroprevalence of IBV among local chickens from Frafraha was 30% and that of Abokobi was 7.7%. This study shows exposure of local chickens in the study communities to IBV.


2017 ◽  
Vol 65 (1) ◽  
pp. 17 ◽  
Author(s):  
S. SEIFI ◽  
S. H. ALIAN SAMAKKHAH ◽  
K. ABSALAN FARD

Measurement of acute phase proteins is important for diagnosis of animal diseases. In the present study, effects of avian infectious bronchitis virus infection on acute phase response and acute phase proteins were determined. Thirty one-day-old commercial broiler chicks were reared in experimental facilities and, at the age of 21 days, were challenged intranasally with 0.2 mL of allantoic fluid virus suspension (titre 106.5 EID50 per 0.1 mL). Serum samples were obtained prior to challenge and on days 1, 2, and 5 post-inoculation. Haptoglobin, serum amyloid A and C- reactive protein concentrations were measured. Our results showed that all investigated acute phase proteins increased significantly after infection, with mean maximum concentrations between 24 h and 48 h. No correlation was observed between plasma acute phase proteins in the chickens prior and post inoculation of the virus. Haptoglobin was most sensitive factor to change in the exposed birds.


Viruses ◽  
2017 ◽  
Vol 9 (8) ◽  
pp. 198 ◽  
Author(s):  
Xiaoxiao Han ◽  
Yiming Tian ◽  
Ru Guan ◽  
Wenqian Gao ◽  
Xin Yang ◽  
...  

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