Exploring the Serum Level of RE1 Silencing Transcription Factor in Alzheimer’s Disease

Objective The aim of this study was to evaluate the serum RE1 silencing transcription factor (REST) level in Alzheimer’s disease (AD), mild cognitive impairment (MCI), and elderly controls by using surface plasmon resonance (SPR) technology. Materials and Methods In this case–control study of 133 subjects, 49 patients with AD, 49 patients with MCI, and 35 elderly controls were recruited. The REST protein concentrations were evaluated by SPR. The resonance unit for each sample was recorded and the concentration of serum REST of study group was derived from the standard curve. All the experiments were done in triplicates. Statistical analysis was done and p-value of < 0.05 was considered as statistically significant. Results A significant difference was observed in the Montreal Cognitive Assessment score, Hindi Mental State Examination scale (HMSE) score education, disease duration, and gender among the groups. A significant (p>0.0001) difference in the duration of disease between AD and MCI was observed. It was observed that the mean concentration of serum REST was not significantly (p = 0.266) different among the groups. Conclusion This study first time evaluated the serum levels of REST in AD, MCI and age-matched elderly controls. The rest levels were similar in all groups; however, it can provide a new direction to future blood-based biomarker studies of REST.

Electromagnetically Induced Transparency (EIT) Like Transmission Based on 3 × 3 Cascaded Multimode Interference Resonators

We propose a method for generating the electromagnetically induced transparency (EIT) like-transmission by using microring resonator based on cascaded 3 × 3 multimode interference (MMI) structures. Based on the Fano resonance unit created from a 3 × 3 MMI coupler with a feedback waveguide, two schemes of two coupled Fano resonator unit (FRU) are investigated to generate the EIT like transmission. The theoretical and numerical analysis based on the coupled mode theory and transfer matrix is used for the designs. Our proposed structure has advantages of compactness and ease of fabrication. We use silicon waveguide for the design of the whole device so it is compatible with the existing Complementary Metal-Oxide-Semiconductor (CMOS) circuitry foundry. The fabrication tolerance and design parameters are also investigated in this study.

Dynamic Simulation of a Metamaterial Beam Consisting of Tunable Shape Memory Material Absorbers

Metamaterials are materials with an artificially tailored internal structure and unusual physical and mechanical properties such as a negative refraction coefficient, negative mass inertia, and negative modulus of elasticity, etc. Due to their unique characteristics, metamaterials possess great potential in engineering applications. This study aims to develop new acoustic metamaterials for applications in semi-active vibration isolation. For the proposed state-of-the-art structural configurations in metamaterials, the geometry and mass distribution of the crafted internal structure is employed to induce the local resonance inside the material. Therefore, a stopband in the dispersion curve can be created because of the energy gap. For conventional metamaterials, the stopband is fixed and unable to be adjusted in real-time once the design is completed. Although the metamaterial with distributed resonance characteristics has been proposed in the literature to extend its working stopband, the efficacy is usually compromised. In order to increase its adaptability to time-varying disturbance, several semi-active metamaterials have been proposed. In this study, the incorporation of a tunable shape memory alloy (SMA) into the configuration of metamaterial is proposed. The repeated resonance unit consisting of SMA beams is designed and its theoretical formulation for determining the dynamic characteristics is established. For more general application, the finite element model of this smart metamaterial is also derived and simulated. The stopband of this metamaterial beam with different configurations in the arrangement of the SMA absorbers was investigated. The result shows that the proposed model is able to predict the unique dynamic characteristics of this smart metamaterial beam. Moreover, the tunable stopband of the metamaterial beam with controlling the state of SMA absorbers was also demonstrated.