colchicine poisoning
Recently Published Documents


TOTAL DOCUMENTS

58
(FIVE YEARS 7)

H-INDEX

17
(FIVE YEARS 0)

2022 ◽  
Vol 29 (1) ◽  
pp. 43-44
Author(s):  
Tatsuya Yokoyama ◽  
Ikuto Otsuki ◽  
Tomohiko Kimijima ◽  
Ryoichi Kawaguchi ◽  
Kazuto Takakuwa ◽  
...  

2021 ◽  
Author(s):  
Xiaoxia Lu ◽  
Yanqing Liu ◽  
Chunyan Wang ◽  
Jianguang Dong ◽  
Lili Bai ◽  
...  
Keyword(s):  

2021 ◽  
Vol 9 ◽  
Author(s):  
Maria Pérez Marín ◽  
Sylvain Prod'hom ◽  
Suzanne Francesca de Villiers ◽  
Thomas Ferry ◽  
Vivianne Amiet ◽  
...  

Colchicine poisoning is associated with a poor prognosis, especially when leading to shock and multi-organ failure, and management is limited to supportive care, including multiple-dose activated charcoal. At therapeutic concentrations, colchicine elimination occurs mainly through hepatic metabolism and involves an enterohepatic circulation, with a small contribution of renal elimination (10–30%). Colchicine toxicokinetics is however rarely described, especially in children. We present the case of a 4-year-old patient who survived a severe iatrogenic colchicine intoxication with a dose of 0.5 mg/kg. She developed multi-organ failure and shock, but recovered after receiving aggressive resuscitation, including extracorporeal life support. Close monitoring of colchicine blood levels showed a plateau for 6 days, indicating impeded elimination resulting from liver failure. We observed no significant clearance from renal replacement therapy, nor activated charcoal, during this period. Extracorporeal life support may play a supportive role in the management of severe colchicine poisoning. However, extracorporeal techniques do not seem to improve colchicine elimination.


2020 ◽  
Vol 9 (4) ◽  
pp. 1-1
Author(s):  
Wei Jiang ◽  
Xuan-Yu Tan ◽  
Jia-Ai Li ◽  
Kang Qu ◽  
Peng Yu ◽  
...  

Author(s):  
Francis Grossenbacher ◽  
Guillaume Giodarno Orsini ◽  
Yoann Cazaubon ◽  
Pierre Fouret ◽  
Zoubir Djerada ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document