Efek Hepatoprotektif Tanaman Obat

Medicinal plant that contain antioxidants is an alternative therapeutic option for liver disorders. This study was aimed to review the hepatoprotective effects of medicinal plants. This was a literature review study using PubMed, Google Scholar and Clinical Key. The results showed 10 hepatoprotective medicinal plants, as follows: soursop leaves, yellow bamboo shoots, moringa leaves, green betel leaves, libo fruit, kenikir, neem leaves, bitter bean seeds, black cumin, and solo garlic. All of them showed hepatoprotective activities based on the results of the tests, using biochemical and histopathological parameters. Soursop leaves could increase SOD level and reduce MDA level; yellow bamboo shoots were demonstrated to maintain SGPT activities and bilirubin level; moringa leaves have been associated with the reduction of MDA, SGOT, and SGPT levels; green betel leaves were able to reduce SGOT and SGPT levels and improve liver centrolobular necrosis; libo fruit was able to lower SGPT level; kenikir and bitter bean seeds were shown to reduce SGOT and SGPT levels; neem leaves were associated with the reduction of ALT level and protection against liver cell damage; black cumin was found to reduce fat degeneration; solo garlic could reduce MDA, SGPT, and SGOT levels, and maintain SOD level. In conclusion, the 10 hepatoprotective medicinal plants have the ability to increase SOD levels, reduce SGOT, SGPT and MDA levels, maintain bilirubin levels, regenerate centrilobular necrosis of the liver, and reduce fat degeneration of the liver. Solo garlic shows the largest amount of hepatoprotective activities, followed by yellow bamboo shoots, green betel leaves and libo fruit.Keywords: medicinal plants, hepatoprotector effect Abstrak: Pengobatan menggunakan tanaman obat yang mengandung antioksidan merupakan pilihan terapi alternatif untuk gangguan pada hati. Penelitian ini bertujuan untuk menelaah efek hepatoprotektif tanaman obat. Jenis penelitian ialah literature review dengan menggunakan PubMed, Google Scholar dan Clinical Key. Hasil penelitian mendapatkan 10 tanaman obat hepatoprotektor yaitu daun sirsak, rebung bambu kuning, daun kelor, daun sirih hijau, buah libo, kenikir, daun mimba, biji petai, jintan hitam, dan bawang lanang. Tanaman-tanaman obat tersebut memiliki aktivitas hepatoprotektif berdasarkan pengujian dengan parameter biokimia dan histopatologi. Daun sirsak dapat meningkatkan kadar SOD dan menurunkan kadar MDA; rebung bambu kuning dapat mempertahankan aktivitas SGPT dan kadar bilirubin; daun kelor menurunkan kadar MDA, SGOT, dan SGPT; daun sirih hijau menurunkan kadar SGOT dan SGPT, serta memperbaiki nekrosis sentrolobuler hati; buah libo menurunkan kadar SGPT; kenikir dan biji petai menurunkan kadar SGOT dan SGPT; daun mimba menurunkan kadar SGPT dan memiliki daya proteksi terhadap kerusakan sel hati; jintan hitam dapat mengurangi degenerasi lemak; bawang lanang menekan peningkatan kadar MDA, SGPT, SGOT dan mempertahankan kadar SOD. Simpulan penelitian ini Kesepuluh tanaman obat hepatoprotektor tersebut memiliki kemampuan dalam meningkatkan kadar SOD, menurunkan kadar SGOT, SGPT dan MDA, mempertahankan kadar bilirubin, memperbaiki nekrosis sentrolobuler hati, dan mengurangi degenerasi lemak hati. Bawang lanang menunjukkan aktivitas hepatoprotektor terbesar, diikuti rebung bambu kuning, daun sirih hijau, dan buah libo.Kata kunci: tanaman obat, efek hepatoprotektor

Hubungan Profil Lipid dan HbA1C dengan Kadar Alanin Aminotransferase pada Pasien Diabetes Melitus Tipe 2

Elevated HbA1C in patients with T2DM will increases the risk of complications. Dyslipidemia is a common comorbidity in patients with T2DM. Uncontrolled T2DM patients and dyslipidemia have a high risk of chronic complications such as non alcoholic fatty liver disease (NAFLD) that causes liver cell damage. Alanine aminotransferase (ALT) test is typically used to detect liver cell damage. This study was aimed to obtain the relationship between lipid profile and HbA1c and ALT among T2DM patients at Prof. Dr. R. D. Kandou Hospital Manado. This was a descriptive and analytical study with a cross sectional design using secondary data of T2DM patients at the Endocrine Polyclinic of Prof. R. D. Kandou Hospital Manado from January to September 2019. The results of the Spearman rank correlation test were, as follows: correlation between ALT and total cholesterol levels with p=0.625 and r=-0.080; correlation between ALT and HDL levels with p =0.302 and r=-0.167; correlation between ALT and LDL levels with p=0.625 and r=-0.080; correlation between ALT and triglyceride levels with p=0.964 and r=-0.007; and correlation between ALT and HbA1c levels with p=0.237 and r=-0.191. In conclusion, there were no significant relationships between lipid profile and HbA1c levels and ALT.Keywords: T2DM, HbA1c, ALT, lipid profile Abstrak: Peningkatan HbA1c pada pasien diabetes melitus tipe 2 (DMT2) akan mening-katkan terjadinya risiko komplikasi. Dislipidemia merupakan komorbid yang umum ditemukan pada pasien DMT2. Penderita DMT2 yang tidak terkontrol disertai dislipidemia memiliki risiko tinggi untuk mendapatkan komplikasi kronik seperti non alcoholic fatty liver disease (NAFLD) yang mengakibatkan kerusakan sel hati. Pemeriksaan laboratorium yang sering dilakukan untuk melihat adanya kerusakan pada sel hati yaitu alanin aminotransferase (ALT). Penelitian ini bertujuan untuk mengetahui hubungan antara profil lipid dan HbA1c dengan kadar ALT pada pasien DMT2 di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah deskriptif analitik dengan desain potong lintang menggunakan data sekunder pasien DMT2 yang datang berobat ke Poliklinik Endokrin RSUP Prof. Dr. R. D. Kandou pada bulan Januari-September 2019. Hasil uji korelasi Spearman rank menunjukkan nilai hubungan antara ALT dan kolesterol total kadar p=0,625 dan r=-0,080; nilai hubungan antara ALT dan kadar HDL p=0,302 dan r=-0,167; nilai hubungan antara ALT dan kadar LDL p=0,625 dan r=-0,080; nilai hubungan antara ALT dan kadar trigliserida p=0,964 dan r=-0,007; serta nilai hubungan antara ALT dan kadar HbA1C p=0,237 dan r=-0,191. Simpulan penelitian ini ialah tidak terdapat hubungan antara profil lipid dan HbA1c dengan kadar ALT.Kata kunci: diabetes melitus tipe 2, HbA1c, ALT, profil lipid

Hubungan Profil Lipid dan HbA1C dengan Kadar Alanin Aminotransferase pada Pasien Diabetes Melitus Tipe 2

Elevated HbA1C in patients with T2DM will increases the risk of complications. Dyslipidemia is a common comorbidity in patients with T2DM. Uncontrolled T2DM patients and dyslipidemia have a high risk of chronic complications such as non alcoholic fatty liver disease (NAFLD) that causes liver cell damage. Alanine aminotransferase (ALT) test is typically used to detect liver cell damage. This study was aimed to obtain the relationship between lipid profile and HbA1c and ALT among T2DM patients at Prof. Dr. R. D. Kandou Hospital Manado. This was a descriptive and analytical study with a cross sectional design using secondary data of T2DM patients at the Endocrine Polyclinic of Prof. R. D. Kandou Hospital Manado from January to September 2019. The results of the Spearman rank correlation test were, as follows: correlation between ALT and total cholesterol levels with p=0.625 and r=-0.080; correlation between ALT and HDL levels with p =0.302 and r=-0.167; correlation between ALT and LDL levels with p=0.625 and r=-0.080; correlation between ALT and triglyceride levels with p=0.964 and r=-0.007; and correlation between ALT and HbA1c levels with p=0.237 and r=-0.191. In conclusion, there were no significant relationships between lipid profile and HbA1c levels and ALT.Keywords: T2DM, HbA1c, ALT, lipid profile Abstrak: Peningkatan HbA1c pada pasien diabetes melitus tipe 2 (DMT2) akan mening-katkan terjadinya risiko komplikasi. Dislipidemia merupakan komorbid yang umum ditemukan pada pasien DMT2. Penderita DMT2 yang tidak terkontrol disertai dislipidemia memiliki risiko tinggi untuk mendapatkan komplikasi kronik seperti non alcoholic fatty liver disease (NAFLD) yang mengakibatkan kerusakan sel hati. Pemeriksaan laboratorium yang sering dilakukan untuk melihat adanya kerusakan pada sel hati yaitu alanin aminotransferase (ALT). Penelitian ini bertujuan untuk mengetahui hubungan antara profil lipid dan HbA1c dengan kadar ALT pada pasien DMT2 di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah deskriptif analitik dengan desain potong lintang menggunakan data sekunder pasien DMT2 yang datang berobat ke Poliklinik Endokrin RSUP Prof. Dr. R. D. Kandou pada bulan Januari-September 2019. Hasil uji korelasi Spearman rank menunjukkan nilai hubungan antara ALT dan kolesterol total kadar p=0,625 dan r=-0,080; nilai hubungan antara ALT dan kadar HDL p=0,302 dan r=-0,167; nilai hubungan antara ALT dan kadar LDL p=0,625 dan r=-0,080; nilai hubungan antara ALT dan kadar trigliserida p=0,964 dan r=-0,007; serta nilai hubungan antara ALT dan kadar HbA1C p=0,237 dan r=-0,191. Simpulan penelitian ini ialah tidak terdapat hubungan antara profil lipid dan HbA1c dengan kadar ALT.Kata kunci: diabetes melitus tipe 2, HbA1c, ALT, profil lipid

Risk factors for developing diastolic dysfunction in nonalcoholic steatohepatitis

In the last 20 years, nonalcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease worldwide, primarily as a result of the epidemic of metabolic syndrome. NAFLD is strongly associated with insulin resistance, glucose intolerance, and dyslipidemia and is currently regarded as the liver manifestation of the metabolic syndrome. Mortality in NAFLD is associated with cardiovascular disease, not with liver failure. Nonalcoholic steatohepatitis (NASH) is a type of NAFLD. NASH suggest about inflammation in liver cell damage.

Hepatoprotective and Antifibrotic Effects of Indonesian Propolis

Liver cirrhosis is the irreversible stage in liver damage process which occurs after liver fibrosis due to necro-inflammatory activities and liver fibrosis. Therefore, inhibition of liver inflammation and fibrosis is very important to prevent liver cirrhosis. This study aimed to analyze the effect of ethanol extract of propolis (EEP) from mount Lawu, Indonesia to prevent liver damage and fibrosis progression in mice with hepatic cirrhosis. This study was performed during the period of June 2018 to May 2019 on a sample of 32 male Balb/C mice divided into control group (P1), induction of carbon tetrachloride (CCl4 ) group (P2), induction of 50 mg/BW CCl4 + EEP group (P3), and (induction of 100 mg/KgBW CCl4 + EEP (P4) with each group consisted of eight mice. The CCl4 in olive oil was administered intraperitoneally three times a week for six weeks. Mean differences between group was determined using ANOVA test with a significance level of 0.05. The induction of CCl4 increased liver cell damage and serum alanin aminotransferase (ALT) level. However, the addition of EEP significantly (p<0.001) reduced liver cell damage as seen in P3 (54.38±4.17 per 100 liver cells) and P4 (37.13±4.36 per 100 liver cells) groups and serum alanin aminotransferase (ALT) as seen in P3 (291.19±113.92 U/L) and P4 (229.38±73.45 U/L) groups. The APRI scores were also reduced after EEP as seen in P3 (0.738±0.292) and P4 (0.513±0.253) groups. Thus, EEP isolates from Gunung Lawu can reduce liver cell damage and fibrosis in mice model of hepatic cirrhosis.

AKTIVITAS HEPATOPROTEKTOR KOMBINASI EKSTRAK AIR PEGAGAN (Centella asiatica L. Urban) DAN EKSTRAK ETANOL KUNYIT (Curcuma longa Linn) TERHADAP TIKUS PUTIH JANTAN SPRAGUE DAWLEY

ABSTRAKHepatoproktektor adalah senyawa yang dapat mencegah dan memperbaiki sel-sel hepar yang rusak. Parameter yang diamati adalah perubahan kadar SGPT pada hari ke 0,2, 5, 9 dan 13. Hasil penelitian dari 9 kombinasi dosis selama 13 hari menunjukkan semua kombinasi menurunkan kadar SGPT dengan aktivitas hepatoprotektor terbaik adalah terdapat pada tumbuhan ektrak air pegagan: ekstrak etanol kunyit dengan perbandingan 2:3.Kata kunci: Pegagan (Centella asiatica L.Urban), Kunyit (Curcuma longa Linn) dan hepatoprotektorABSTRACTHepatoprotector is a compound that can prevent and repair liver cell damage. This research aimed to study the activity and effectivity of combination Centella asiatica water extract and Curcuma longa ethanol extract as hepatoprotector by SGPT (Serum Glutamat Piruvat Transaminase) in Sprague Dawley male white rats induced paracetamol. Parameters measured were changes in ALT levels at day 0, 2, 5, 9 and 13. Combinations of doses for 13 days showed all combinations of those extract potencial hepatoprotector. The best activity was found in ratio 2:3 (Centella asiatica extract:ethanol extract of turmeric).Keywords: Centella asiatica L. Urban, Curcuma longa Linn and Hepatoprotector