Effects of different fatty acids on BRL3A rat liver cell damage

2020 ◽  
Vol 235 (9) ◽  
pp. 6246-6256
Author(s):  
Wei Yang ◽  
Runqi Liu ◽  
Cheng Xia ◽  
Yuanyuan Chen ◽  
Zhihao Dong ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Rat Liver ◽  
Liver Cell ◽  
Cell Damage ◽  
Liver Cell Damage

scholarly journals Hepatoprotective and Antifibrotic Effects of Indonesian Propolis

2019 ◽  
Vol 51 (3) ◽  
pp. 134-140
Author(s):  
Diding Heri Prasetyo ◽  
Sarsono Sarsono ◽  
Ida Nurwati ◽  
Prihandjojo Andri Putranto ◽  
Martini Martini ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Liver Fibrosis ◽  
Liver Damage ◽  
Liver Cell ◽  
Hepatic Cirrhosis ◽  
Cell Damage ◽  
Liver Cells ◽  
Control Group ◽  
Mice Model ◽  
Liver Cell Damage

Liver cirrhosis is the irreversible stage in liver damage process which occurs after liver fibrosis due to necro-inflammatory activities and liver fibrosis. Therefore, inhibition of liver inflammation and fibrosis is very important to prevent liver cirrhosis. This study aimed to analyze the effect of ethanol extract of propolis (EEP) from mount Lawu, Indonesia to prevent liver damage and fibrosis progression in mice with hepatic cirrhosis. This study was performed during the period of June 2018 to May 2019 on a sample of 32 male Balb/C mice divided into control group (P1), induction of carbon tetrachloride (CCl4 ) group (P2), induction of 50 mg/BW CCl4 + EEP group (P3), and (induction of 100 mg/KgBW CCl4 + EEP (P4) with each group consisted of eight mice. The CCl4 in olive oil was administered intraperitoneally three times a week for six weeks. Mean differences between group was determined using ANOVA test with a significance level of 0.05. The induction of CCl4 increased liver cell damage and serum alanin aminotransferase (ALT) level. However, the addition of EEP significantly (p<0.001) reduced liver cell damage as seen in P3 (54.38±4.17 per 100 liver cells) and P4 (37.13±4.36 per 100 liver cells) groups and serum alanin aminotransferase (ALT) as seen in P3 (291.19±113.92 U/L) and P4 (229.38±73.45 U/L) groups. The APRI scores were also reduced after EEP as seen in P3 (0.738±0.292) and P4 (0.513±0.253) groups. Thus, EEP isolates from Gunung Lawu can reduce liver cell damage and fibrosis in mice model of hepatic cirrhosis.

Plasma Enzyme and Isoenzyme Changes during Perfusion of the Isolated Pig Liver

1974 ◽  
Vol 46 (1) ◽  
pp. 105-112
Author(s):  
J. E. Buttery ◽  
S. P. Parbhoo ◽  
D. N. Baron
Keyword(s):  
Lactate Dehydrogenase ◽  
Dehydrogenase Activity ◽  
Liver Damage ◽  
Liver Cell ◽  
Cell Damage ◽  
Sorbitol Dehydrogenase ◽  
Ornithine Carbamoyltransferase ◽  
Aspartate Transaminase ◽  
Pig Liver ◽  
Liver Cell Damage

1. Changes in the perfusate activities of aspartate transaminase, lactate dehydrogenase, its ‘LD-5’ component, sorbitol dehydrogenase, ornithine carbamoyltransferase, and the isoenzyme patterns of lactate dehydrogenase and aspartate transaminase, were investigated in eleven perfusions of pig liver with human blood in order to assess liver cell damage during perfusion. 2. The aspartate transaminase values were a sensitive indicator of liver damage provided that, as was usually the case, the degree of haemolysis was small. Appearance on electrophoresis of the mitochondrial isoenzyme of aspartate transaminase indicated severe liver damage. 3. Measurement of sorbitol dehydrogenase activity was also shown to be a sensitive index of liver cell damage, and had the advantage that haemolysis did not interfere. 4. Measurement of total lactate dehydrogenase activity was unreliable as this largely reflected the degree of haemolysis rather than liver cell damage. However, the isoenzyme pattern of lactate dehydrogenase on electrophoresis distinguished liver cell damage from haemolysis. The chemical determination of ‘LD-5’ was not a sensitive index of pig liver damage as this fraction is found only in low concentration in pig liver. 5. Ornithine carbamoyltransferase was also found not to be a sensitive marker of liver cell damage.

Mechanisms of liver cell damage and repair

1999 ◽  
Vol 11 (9) ◽  
pp. 949-956 ◽  
Author(s):  
Richard K. Thomson ◽  
Michael J. P. Arthur
Keyword(s):  
Liver Cell ◽  
Cell Damage ◽  
Liver Cell Damage

Hepatitis A virus replication in tamarins and host immune response in relation to pathogenesis of liver cell damage

1986 ◽  
Vol 18 (3) ◽  
pp. 261-276 ◽  
Author(s):  
P. Karayiannis ◽  
T. Jowett ◽  
M. Enticott ◽  
D. Moore ◽  
M. Pignatelli ◽  
...  
Keyword(s):  
Immune Response ◽  
Virus Replication ◽  
Liver Cell ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Cell Damage ◽  
Host Immune Response ◽  
Liver Cell Damage

Rat Liver Storage Iron and Plasma Ferritin during d-Galactosamine-Hcl-Induced Hepatitis

1980 ◽  
Vol 58 (4) ◽  
pp. 321-325 ◽  
Author(s):  
F. M. J. Zuyderhoudt ◽  
G. G. A. Jörning ◽  
J. G. De Haan ◽  
G. Samson ◽  
J. Van Gool
Keyword(s):  
Acute Phase ◽  
Iron Metabolism ◽  
Liver Cell ◽  
Cell Damage ◽  
Mean Value ◽  
Liver Cell Damage ◽  
Ferritin Iron ◽  
Initial Decrease ◽  
Liver Ferritin ◽  
Iron Fraction

1. d-Galactosamine-HCl induces toxic hepatitis in the rat and was used as a model to study some aspects of iron metabolism during liver cell damage. Some changes in iron metabolism were similar to those encountered in human acute viral hepatitis. 2. During the first 3 days of liver cell damage induced by galactosamine, liver depot iron and especially ferritin iron decreased by approximately 20%. Plasma ferritin rose, with a peak mean value which was approximately 20 times the concentration measured in normal rats. 3. During the acute phase, plasma ferritin did not accurately reflect the change in the level of liver depot iron. 4. During and after the acute phase, liver depot iron increased after an initial decrease. The non-ferritin depot iron fraction was elevated approximately 75% compared with the value in normal rats. This increase in non-ferritin iron was probably caused by increased erythrocyte catabolism in the liver and recapture followed by catabolism of liver ferritin that had leaked into the blood.

The role of acrolein in allyl alcohol-induced lipid peroxidation and liver cell damage in mice

1987 ◽  
Vol 36 (1) ◽  
pp. 51-57 ◽  
Author(s):  
Hartmut Jaeschke ◽  
Christin Kleinwaechter ◽  
Albrecht Wendel
Keyword(s):  
Lipid Peroxidation ◽  
Liver Cell ◽  
Allyl Alcohol ◽  
Cell Damage ◽  
Liver Cell Damage
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