thymidine labelling
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APOPTOSIS ◽  
2003 ◽  
Vol 8 (2) ◽  
pp. 199-208 ◽  
Author(s):  
S. N. Orlov ◽  
D. V. Pchejetski ◽  
S. D. Sarkissian ◽  
V. Adarichev ◽  
S. Taurin ◽  
...  

1999 ◽  
Vol 162 (3) ◽  
pp. 341-350 ◽  
Author(s):  
J Mirosevich ◽  
JM Bentel ◽  
N Zeps ◽  
SL Redmond ◽  
MF D'Antuono ◽  
...  

Maintenance of the size and differentiated function of the adult prostate is dependent on testicular androgens. In this study, simultaneous androgen receptor (AR) immunohistochemistry and [(3)H]thymidine labelling was used to characterise the proliferating epithelial cells of the murine ventral prostate. Proliferation in the adult prostate was more prevalent in the basal cell population with 1.8 AR-negative cells labelled with [(3)H]thymidine as compared with 0.7% AR-expressing luminal cells. Three weeks following castration of mice, the atrophied prostate contained rudimentary glands composed of both luminal and basal cells with the proportion of AR-expressing basal cells reduced from 50 to 25%. Administration of testosterone enanthate to castrated mice induced a recapitulation of the prostate gland that was preceded by up-regulation of AR expression in basal cells to normal adult levels (50% AR-positive cells) by 12 h following testosterone injection. Proliferation of AR-positive luminal cells peaked at 48 h (22.8%) while proliferation of AR-negative basal cells peaked at 96 h (6.1%) following testosterone administration. These results suggest that distinct populations of luminal and basal cells are resistant to castration-induced involution of the prostate but remain responsive to direct or indirect testosterone effects and recapitulate the gland following administration of testosterone.


1998 ◽  
Vol 34 ◽  
pp. S21
Author(s):  
P. Pronzato ◽  
M.R. Sertoli ◽  
M. Venturini ◽  
L. Del Mastro ◽  
P. Queirolo ◽  
...  

Dermatology ◽  
1998 ◽  
Vol 197 (2) ◽  
pp. 123-126 ◽  
Author(s):  
M. Heenen ◽  
S. Thiriar ◽  
J.-C. Noël ◽  
P. Galand

1997 ◽  
Vol 30 (3) ◽  
pp. 117-126 ◽  
Author(s):  
A. Becciolini ◽  
M. Balzi ◽  
M. Barbarisi ◽  
P. Faraoni ◽  
A. Biggeri ◽  
...  

1997 ◽  
Vol 30 (3-4) ◽  
pp. 117-126 ◽  
Author(s):  
A. Becciolini ◽  
M. Balzi ◽  
M. Barbarisi ◽  
P. Faraoni ◽  
A. Biggeri ◽  
...  

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