Re-evaluation of the mechanism of cytotoxicity of dialkylated lariat ether compounds

The cytotoxicity of dialkylated lariat ethers has been previously attributed to their ionophoric properties.

Mass Spectrometry Reveals Complexing Properties of Modified PNP-Lariat Ether Containing Benzyl Derivative of (S)–Prolinamine

In the investigation presented here the synthesis of new lariat ether derivative obtained from the modification of tetrapyrrolidinyl-PNP-crown ether macrocycle is described. The polyheterotopic molecular coreceptor consisted of the replacement of chlorine atoms with an optically active (S)-(1-benzylpyrrolidin-2-yl) methanamine. The structure was confirmed by using elemental analysis, mass spectrometry, and NMR spectroscopy. This work covers results concerning the complexing properties of the new ligand towards Ag+, Cu2+, Co2+, Ni2+, and Zn2+ ions. The formation of non-covalent complexes of 1:1 stoichiometry with the Cu2+, Co2+, Ni2+, and Zn2+ ions have been confirmed by mass spectrometry. Due to the previous work and application possibilities, a large emphasis was put on the investigation of the complexation ability of lariat ether with silver (I) cation to determine stability constants by direct potentiometric method. In this case, the formation of four different forms of complexes AgL, Ag2L, Ag3L, and Ag4L has been proved. The observed unusual binding through the nitrogen atoms from the exocyclic substituents may provide the structural unit to build a new coordination polymers.

Exocyclic self-assembly behavior of carboxylic acid and lariat ether macrocyclic hosts: regulation by pendent arm

An exocyclic supramolecular building block through O–H⋯N hydrogen bonding interaction for the assembly of di-sidearm dibenzo-diazacrown ethers bearing a flexibility sidearm with PTA acid.

Studies of the complexation behavior of tetramorpholinylo-PNP-lariat ether with Ag(i), Ca(ii), Cd(ii), Cu(ii) and Pb(ii) using Electrospray Ionization Mass Spectrometry

The identification of complexes containing PNP-lariat ether with Ag(i), Ca(ii), Cu(ii), Cd(ii) and Pb(ii) by ESI-MS technique is presented. The tandem mass spectra of these complexes were done in order to evaluate the stability of the different types of the complexes formed.