marginal zone macrophages
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2018 ◽  
Vol 96 (3) ◽  
pp. 298-315
Author(s):  
Chetna Soni ◽  
Stephanie L Schell ◽  
Melinda J Fasnacht ◽  
Sathi Babu Chodisetti ◽  
Ziaur SM Rahman

2016 ◽  
Vol 197 (6) ◽  
pp. 2063-2068 ◽  
Author(s):  
Kajsa E. Prokopec ◽  
Anna-Maria Georgoudaki ◽  
Silke Sohn ◽  
Fredrik Wermeling ◽  
Hans Grönlund ◽  
...  

Transfusion ◽  
2016 ◽  
Vol 56 (7) ◽  
pp. 1834-1844 ◽  
Author(s):  
Anders Larsson ◽  
Andreas Hult ◽  
Anna Nilsson ◽  
Mattias Olsson ◽  
Per-Arne Oldenborg

Blood ◽  
2011 ◽  
Vol 117 (20) ◽  
pp. 5403-5412 ◽  
Author(s):  
Tracy L. McGaha ◽  
Yunying Chen ◽  
Buvana Ravishankar ◽  
Nico van Rooijen ◽  
Mikael C. I. Karlsson

Abstract Marginal zone macrophages (MZMs) are a small subset of specialized splenic macrophages known to interact with apoptotic material entering the spleen from circulation. To evaluate whether MZMs regulate immunity to apoptotic material we depleted MZMs and assessed innate and adaptive immune responses to apoptotic cells administered systemically. MZM depletion altered the spatial localization of apoptotic cells, which accumulated in T-cell areas of the lymphoid follicles. MZM depletion also enhanced phagocytosis of apoptotic cells by red pulp (CD68+F4/80+) macrophages, which expressed increased CD86, MHCII, and CCR7. MZM depletion led to increased production of proinflammatory cytokines and enhanced lymphocyte responsiveness to apoptotic cell antigens. Furthermore, we found that MZM depletion accelerated autoimmune disease progression in mice genetically prone to systemic lupus erythematosus and caused significant mortality in wild-type mice repeatedly exposed to exogenous apoptotic thymocytes. These findings support the hypothesis that MZMs are central in the clearance of apoptotic cells to minimize the immunogenicity of autoantigens.


2011 ◽  
Vol 186 (6) ◽  
pp. 3441-3451 ◽  
Author(s):  
Shirin Z. Birjandi ◽  
Jill A. Ippolito ◽  
Anand K. Ramadorai ◽  
Pamela L. Witte

2011 ◽  
Vol 186 (4) ◽  
pp. 2172-2181 ◽  
Author(s):  
Yuying You ◽  
Riley C. Myers ◽  
Larry Freeberg ◽  
Jeremy Foote ◽  
John F. Kearney ◽  
...  

2008 ◽  
Vol 59 (6) ◽  
pp. 625-626
Author(s):  
D. Finke ◽  
R. Hoerster ◽  
C. Brockmann ◽  
K. Kropf ◽  
H. Hennig ◽  
...  

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